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Dear Colleagues,

This Special Issue will focus on the management of lower-extremity peripheral artery disease (PAD). More than 235 million people worldwide suffer from PAD, which remains underdiagnosed and undertreated. The clinical spectrum of the disease is broad, ranging from no symptoms to exertional limb symptoms or wounds. Different methods can be used by clinicians to make a diagnosis depending on the disease stage. Despite the increasing interest in PAD management over the past decade, with randomized controlled trials focusing on patients with PAD, there is still a great deal to be done.

This Special Issue aims to complete the first Special Issue about the clinical/biological management of PAD, with a further aim to provide a forum for the discussion of original perspectives (health policies, e-health, etc.) from the diagnosis to the treatment of PAD, in order to improve clinical practice.

We invite the submission of original research articles and reviews dealing with diagnostic approaches, imaging, treatments, and all the different aspects of PAD management.

Prof. Dr. Guillaume Mahe
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

peripheral artery disease
ankle-brachial index
medical therapy
endovascular therapy
exercise therapy
diet
diagnosis methods

Published Papers (2 papers)

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Open AccessOpinion

Arterial Blood-Flow Acceleration Time on Doppler Ultrasound Waveforms: What Are We Talking About?

and

J. Clin. Med. 2023, 12(3), 1097; https://doi.org/10.3390/jcm12031097 - 31 Jan 2023

Viewed by 843

Abstract

In recent years, the assessment of systolic acceleration in lower-extremity peripheral artery disease (PAD) has been brought back into the spotlight, whatever measure is used: time (in s) or acceleration (in cm.s⁻²). Acceleration time (also called systolic rise time) and maximal acceleration are two different but very useful measurements of growing interest in PAD. A background of the historical development, physics rationale, semantics, and methods of measurement, as well as their strengths and weaknesses, are discussed herein. Acceleration time is a powerful tool for predicting significant arterial stenosis or for estimating the overall impact of PAD as it is highly correlated to the ankle or toe pressure indexes. It could even become a new diagnostic criterion for critical limb ischemia. Similarly, maximal systolic acceleration ratios are highly predictive of carotid or renal stenosis. However, the literature lacks reference standards or guidelines for the assessment of such variables, and their measurement techniques seem to differ between authors. We propose herein a semantic and measurement statement order to clarify and help standardize future research. Full article

(This article belongs to the Special Issue Peripheral Artery Disease: From Diagnosis to Treatment — Part II)

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Open AccessStudy Protocol

A Multicenter, Investigator-Blinded, Randomized Controlled Trial to Assess the Efficacy of Calf Neuromuscular Electrical Stimulation Program on Walking Performance in Peripheral Artery Disease: The ELECTRO-PAD Study Protocol

Alexis Le Faucheur

Pierre Jéhannin

Adrien Chanteau

Pauline Blanc-Petitjean

Alan Donnelly

Clément Hoffmann

Samir Henni

Alessandra Bura-Rivière

Adrien Kaladji

Damien Lanéelle

and

Guillaume Mahé

J. Clin. Med. 2022, 11(24), 7261; https://doi.org/10.3390/jcm11247261 - 07 Dec 2022

Viewed by 575

Abstract

This paper describes a currently on-going multicenter, randomized controlled trial designed to assess the efficacy of calf neuromuscular electrical stimulation (NMES) on changes in maximal walking distance in people with lower extremity peripheral artery disease (PAD), compared with a non-intervention control-group. This study (NCT03795103) encompasses five participating centers in France. PAD participants with a predominant claudication at the calf level and a maximal treadmill walking distance ≤300 m are randomized into one of the two groups: NMES group or Control group. The NMES program consists of a 12-week program of electrical stimulations at the calf-muscle level. The primary outcome of the study is the change in maximal treadmill walking distance at 12 weeks. Main secondary outcomes include changes in the pain-free treadmill walking distance; 6 min total walking distance; global positioning system (GPS)-measured outdoor walking capacity; daily physical activity level by accelerometry; self-reported walking impairment; self-reported quality of life; ankle-brachial index; and skin microvascular function, both at the forearm and calf levels. Recruitment started in September 2019 and data collection is expected to end in November 2022. Full article

(This article belongs to the Special Issue Peripheral Artery Disease: From Diagnosis to Treatment — Part II)

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