Special Issue "Disseminated Intravascular Coagulation: Current Understanding and Future Perspectives—Part II"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: 31 March 2023 | Viewed by 895

Special Issue Editor

Department of Emergency Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan
Interests: disseminated intravascular coagulation; sepsis; trauma; post-cardiac arrest syndrome; COVID-19; immunology; endothelial dysfunction; systematic review; clinical practice guidelines; randomized controlled trials
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Special Issue Information

Dear Colleagues,

In January 2020, our Special Issue titled “Disseminated Intravascular Coagulation: Current Understanding and Future Perspectives” was launched (https://www.mdpi.com/journal/jcm/special_issues/disseminated_intravascular). Many manuscripts have been published about different topics in disseminated intravascular coagulation, including novel studies about the promising diagnosis and treatment of the syndrome. Disseminated intravascular coagulation is characterized by the systemic activation of blood coagulation, which results in the generation and deposition of fibrin, leading to microvascular thrombi in various organs and contributing to multiple organ dysfunction. Additionally, simultaneous neutrophil activation and endothelial injury associated with glycocalyx perturbation have been observed in these patients. Although there have been several recent advances in the pathophysiology of disseminated intravascular coagulation, the clinical significance of diagnoses and therapeutic interventions targeting disseminated intravascular coagulation is still uncertain. Therefore, understanding the pathophysiology of disseminated intravascular coagulation and novel therapeutic strategies are vitally important issues for the management of critically ill settings.

Given the enormous success of the first release, I believe that it is time to move forward to a second volume of this Special Issue, collecting additional insights into disseminated intravascular coagulation. In this coming Special Issue of Journal of Clinical Medicine, we will discuss the etiology, pathophysiology, clinical manifestations, diagnostics, and optimal management to treat critically ill patients with disseminated intravascular coagulation. We are very keen to attract a global audience, welcoming any contributions on this subject from around the world.

We welcome both solicited and unsolicited submissions that will contribute to this goal.

Dr. Kazuma Yamakawa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • anticoagulant therapy
  • cancer
  • COVID-19
  • disseminated intravascular coagulation
  • endothelial dysfunction
  • hematological malignancy
  • immunology
  • precision medicine
  • sepsis
  • trauma

Published Papers (1 paper)

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Special Issue on “Disseminated Intravascular Coagulation: Current Understanding and Future Perspectives”
J. Clin. Med. 2022, 11(12), 3315; https://doi.org/10.3390/jcm11123315 - 09 Jun 2022
Viewed by 738
Disseminated intravascular coagulation (DIC) is characterized by the systemic activation of blood coagulation that generates and deposits fibrin that causes microvascular thrombi to develop in various organs, which contributes to multiple organ dysfunction [...] Full article
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