Dear Colleagues,

In January 2020, our Special Issue titled “Disseminated Intravascular Coagulation: Current Understanding and Future Perspectives” was launched (https://www.mdpi.com/journal/jcm/special_issues/disseminated_intravascular). Many manuscripts have been published about different topics in disseminated intravascular coagulation, including novel studies about the promising diagnosis and treatment of the syndrome. Disseminated intravascular coagulation is characterized by the systemic activation of blood coagulation, which results in the generation and deposition of fibrin, leading to microvascular thrombi in various organs and contributing to multiple organ dysfunction. Additionally, simultaneous neutrophil activation and endothelial injury associated with glycocalyx perturbation have been observed in these patients. Although there have been several recent advances in the pathophysiology of disseminated intravascular coagulation, the clinical significance of diagnoses and therapeutic interventions targeting disseminated intravascular coagulation is still uncertain. Therefore, understanding the pathophysiology of disseminated intravascular coagulation and novel therapeutic strategies are vitally important issues for the management of critically ill settings.

Given the enormous success of the first release, I believe that it is time to move forward to a second volume of this Special Issue, collecting additional insights into disseminated intravascular coagulation. In this coming Special Issue of Journal of Clinical Medicine, we will discuss the etiology, pathophysiology, clinical manifestations, diagnostics, and optimal management to treat critically ill patients with disseminated intravascular coagulation. We are very keen to attract a global audience, welcoming any contributions on this subject from around the world.

We welcome both solicited and unsolicited submissions that will contribute to this goal.

Dr. Kazuma Yamakawa
Guest Editor

Manuscript Submission Information

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• anticoagulant therapy
• cancer
• COVID-19
• disseminated intravascular coagulation
• endothelial dysfunction
• hematological malignancy
• immunology
• precision medicine
• sepsis
• trauma