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Special Issue "The Alcohol Hangover: Causes, Consequences, and Treatment-Part II"

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A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Mental Health".

Deadline for manuscript submissions: closed (15 February 2022) | Viewed by 6726

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Dr. Joris C. Verster

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Guest Editor

1. Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands
2. Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, Australia
Interests: immune fitness; COVID-19; mood; sleep; alcohol; hangover
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Dr. Sarah Benson

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Guest Editor

Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, Australia
Interests: cognitive psychology; psychopharmacology; alcohol; caffeine; cognitive enhancement; alcohol hangover

Special Issue Information

Dear Colleagues,

Since the founding of the Alcohol Hangover Research Group in 2010, research on alcohol hangovers has been increasing and on the move. This research focusses on the causes, consequences, and treatment of alcohol hangover.

Alcohol hangover refers to the combination of negative mental and physical symptoms which can be experienced after a single episode of alcohol consumption, starting when the blood alcohol concentration (BAC) approaches zero (Verster et al., 2020). Research has identified as many as 47 different symptoms that can be experienced during the alcohol hangover state (Penning et al., 2012). A recent study investigated the presence and severity of the most common hangover symptoms among 1837 social drinkers (Van Schrojenstein Lantman et al., 2017). The four symptoms with the biggest combined impact on mood, cognitive performance, and physical functioning were being tired, sleepiness, concentration problems, and headache. Research has pointed at the socioeconomic consequences of experiencing these symptoms in terms of absenteeism versus presenteeism and an increased risk of having accidents. Alcohol hangover effects can also significantly impair daily activities such as driving a car.

Today, much remains unknown about the pathology of alcohol hangover. However, current research into alcohol metabolism and the immune system significantly increases our understanding of the alcohol hangover. Other researchers have focused on genetics, behavioral aspects, personality, and psychological correlates of the alcohol hangover, or the impact of food and daily diet. The obtained knowledge is essential to developing the ideal hangover treatment. Unfortunately, despite the high consumer demand for an effective and safe hangover treatment, scientific research on the efficacy of hangover treatments and cures is scarce.

The present Special Issue aims to provide an overview of the latest research on the causes, consequences, and treatment of alcohol hangover. The combination of original research articles and review papers will provide clinicians with up-to-date knowledge on alcohol hangover.

Dr. Joris Verster
Dr. Sarah Benson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Alcohol
Hangover
Pathology
Treatment
Cognitive functioning
Physical functioning
Mood
Predictors

Published Papers (4 papers)

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Research

Open AccessArticle

Associations between Mental Resilience, Mood, Coping, Personality, and Hangover Severity

and

J. Clin. Med. 2022, 11(8), 2240; https://doi.org/10.3390/jcm11082240 - 17 Apr 2022

Cited by 1 | Viewed by 2553

Abstract

Extensive research exists on relationships between psychological constructs and alcohol consumption. However, research on relationships with hangover severity remains limited. This study aimed to assess the associations between mental resilience, mood (i.e., depression, anxiety, and stress), coping, personality, and hangover severity. A total of N = 690 participants completed an online survey by answering questions regarding their demographics, alcohol use, hangover prevalence and severity, and several psychological assessments (Brief Resilience Scale, DASS-21, Brief Cope, and Brief Version of the Big Five Personality Inventory). Significant associations were found between hangover severity and mental resilience, mood, and avoidant coping. Higher levels of mental resilience were associated with less severe hangovers, whereas poorer mood was associated with more severe hangovers. No significant associations were found with personality traits. These findings demonstrate that several associations between psychological constructs and hangover severity exist and suggest a role of psychological factors in the pathology of the alcohol hangover. As our findings contrast with the results of previous studies that did not report an association between mental resilience and the presence and severity of hangovers, further research is warranted. Full article

(This article belongs to the Special Issue The Alcohol Hangover: Causes, Consequences, and Treatment-Part II)

Open AccessArticle

The Relationship between Alcohol Hangover Severity, Sleep and Cognitive Performance; a Naturalistic Study

and

J. Clin. Med. 2021, 10(23), 5691; https://doi.org/10.3390/jcm10235691 - 03 Dec 2021

Cited by 2 | Viewed by 1356

Abstract

Alcohol hangover (AH) has been associated with poor sleep due to the negative effects of alcohol intoxication on sleep quantity and sleep quality. The aim of the current study was to further explore the relationship between AH severity and sleep using a naturalistic study design. A further aim was to determine whether quantitative aspects of sleep were a mediating influence on the relationship between AH severity and cognitive performance. As part of the naturalistic study design, 99 drinkers were recruited following a night of drinking in an Australian state capital, with breath alcohol concentration (BrAC) measured as participants were leaving the entertainment district. The following morning at home, participants answered online questions regarding their drinking behaviour on the previous evening, current AH symptoms and sleep quality. Participants also completed an online version of the Trail-Making Test B (TMT-B) to assess cognitive performance. The findings reveal the duration of nightly awakenings to be negatively related to six individual AH symptoms as well as overall AH severity. The number of nightly awakenings, sleep quality and total sleep time correlated with four AH symptoms including overall AH severity. Total AH severity accounted for a moderate amount of variance (11%) in the time to complete the TMT-B. These findings confirm that alcohol consumption negatively affects sleep, which is related to higher next-day hangover severity ratings and poorer cognitive performance. Full article

(This article belongs to the Special Issue The Alcohol Hangover: Causes, Consequences, and Treatment-Part II)

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Open AccessArticle

Transition to Online Education during the COVID-19 Pandemic: Impact of Changes in Alcohol Consumption and Experiencing Hangovers on Academic Functioning

Agnese Merlo

Pauline A. Hendriksen

and

J. Clin. Med. 2021, 10(22), 5332; https://doi.org/10.3390/jcm10225332 - 16 Nov 2021

Cited by 6 | Viewed by 1389

Abstract

In the Netherlands, the 2019 coronavirus (COVID-19) pandemic had a significant impact on daily life, with two extensive lockdowns enforced to combat the spread of the SARS-CoV-2 virus. These measures included the closure of bars and restaurants, and the transition from face-to-face to online education. A survey was conducted among Dutch pharmacy students and PhD-candidates to investigate the impact of COVID-19 lockdown on alcohol consumption, hangovers, and academic functioning. The analysis revealed a significant reduction in both quantity and frequency of alcohol consumption during the COVID-19 lockdown periods. This was accompanied with a significant reduction in hangover frequency and lower hangover severity during COVID-19 lockdown periods. The distribution of scores on academic performance showed great variability between respondents: while some participants reported impairment, others reported improved performance during the COVID-19 pandemic, or no change. Women reported that significantly more time investment was associated with maintaining these performance levels. Consistent among participants was the notion of reduced interactions with teachers and other students. Participants who reported more hangovers and most severe hangovers before COVID-19 benefited from the lockdown periods in terms of improved academic performance. Positive correlations were found between study grades/output and both the frequency and severity of hangovers experienced before COVID-19, suggesting that heavier drinkers, in particular, improved academic performance during the lockdown periods. In conclusion, COVID-19 lockdowns were associated with a significant reduction in both alcohol consumption and experiencing hangovers, which was, among heavier drinkers particularly, associated with significantly improved academic functioning. Full article

(This article belongs to the Special Issue The Alcohol Hangover: Causes, Consequences, and Treatment-Part II)

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Figure 1

Open AccessArticle

The 5HTOL/5HIAA Ratio as a Biomarker of Alcohol Hangover

Marlou Mackus

Aurora J. A. E. van de Loo

Willie J. M. van den Bogaard

Gerdien A. H. Korte-Bouws

Johan Garssen

and

Joris C. Verster

J. Clin. Med. 2021, 10(18), 4241; https://doi.org/10.3390/jcm10184241 - 18 Sep 2021

Cited by 2 | Viewed by 845

Abstract

Assessment of the presence and severity of alcohol hangovers relies on the subjective method of self-report. Therefore, there is a need of adequate biomarkers that (1) correlate significantly with hangover severity, and (2) correspond to the level of hangover-related performance impairment objectively. In this naturalistic study, n = 35 social drinkers participated. Urine samples were obtained the morning after alcohol consumption and after an alcohol-free control day. Concentrations of 5-hydroxytryptophol (5-HTOL), 5-hydroxyindoleacetic acid (5-HIAA) and the 5-HTOL/5-HIAA ratio were determined. The results confirm previous findings that 5-HTOL and the 5HTOL/5-HIAA ratio are useful biomarkers of recent alcohol consumption. Significant correlations were found with the amount of alcohol consumed, total drink time, and estimated BAC. However, urine concentrations of 5-HTOL and 5-HIAA (and their ratio 5HTOL/5-HIAA) did not significantly correlate with hangover severity. In conclusion, urine 5-HTOL, 5-HIAA, and the 5HTOL/5-HIAA ratio cannot be considered to be suitable biomarkers of alcohol hangover. Full article

(This article belongs to the Special Issue The Alcohol Hangover: Causes, Consequences, and Treatment-Part II)

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Special Issue "The Alcohol Hangover: Causes, Consequences, and Treatment-Part II"

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