Special Issue "Acute Myeloid Leukemia (AML): Novel Therapeutic Approaches"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: closed (20 February 2023) | Viewed by 132

Special Issue Editor

1. Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, 16132 Genova, Italy
2. IRCCS-Ospedale Policlinico San Martino, 16132 Genova, Italy
Interests: acute myeloid leukemia; minimal residual disease; stem cell transplantation; NK cells; CPX-351; BCL2-inhibitors; new drugs

Special Issue Information

Dear Colleagues,

Many improvements have been achieved in the last few years in the understanding of the biologic mechanism of Acute Myeloid Leukemia (AML) and, for the first time in decades, several new drugs have been introduced as well.

As a consequence, the WHO classification of AML and the prognostic risk scores such as European Leukemia Net (ELN) have become significantly more complicated in their last edition, if compared to the first attempts of classification and prognostication in AML.

Therefore, for newly diagnosed patients, a great deal of information should be obtained before starting induction therapy, in order to maximize the efficacy. For instance, non-high-risk patients with CD33 expression may benefit from CD33-targeting antibodies, patients with mutated FLT3 may benefit from TKI, patients with secondary AML or therapy related AML may benefit from CPX-351 instead of conventional chemotherapy,, etc. Furthermore, minimal residual disease assessment by flow cytometry, RT-PCR, NGS may allow to refine the definition of response to treatment, thus helping to allocate patients to stem cell transplantation consolidation more efficiently.

However, despite all those advances, several issues remain to be resolved. The treatment of elderly and unfit patients has seen a significant improvement with the introduction of the BCL-2 inhibitor venetoclax in addition to hypomethylating therapy, but median survival is still disappointing and cure is still unlikely in this setting. Furthermore, high risk disease is still an open issue, with an unsatisfying outcome even among younger, fit patients.

From a more biological point of view, many patients are still classified among the heterogeneous “AML not otherwise specified” group and this is often reflected in the risk assessment, with a big proportion of patients still considered at “intermediate” risk.

Undoubtedly, there is still need for improvement and several trial testing new molecules to be included in more conventional backbones are ongoing, and a more precise understanding of the biology of the disease achieved through ongoing biological studies will help to improve the classification at diagnosis.

In this Special Issue, we solicit clinical studies with emphasis on: new drugs for AML treatment, with particular focus on elderly unfit patient population; novel insights on genomic landscape of AML that may improve the risk assessment at diagnosis and on novel approach to AML treatment, including minimal residual disease assessment-driven treatment and novel strategy aimed to improve the application of allogeneic stem cell transplantation.

Both original research papers and comprehensive review papers are welcome.

Dr. Fabio Guolo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • acute myeloid leukemia
  • prognosis
  • classification
  • risk score
  • new drugs
  • minimal residual disease
  • NGS
  • genomic landscape
  • stem cell transplantation
  • immunotherapy
  • precision medicine

Published Papers

There is no accepted submissions to this special issue at this moment.
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