jcm-logo

Journal Browser

Journal Browser

Fertility Challenges: Modern Management Strategies and Assisted Reproductive Technologies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Reproductive Medicine & Andrology".

Deadline for manuscript submissions: 15 July 2026 | Viewed by 203

Special Issue Editor


E-Mail Website
Guest Editor
Policlinico Federico II Hospital, University of Naples Federico II, Naples, Italy
Interests: ovarian reserve; antral follicle count; 3D-AFC; fertility preservation; fertility in multiple sclerosis; assisted repro-ductive technology; ovarian stimulation; IVF pregnancy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, titled "Fertility Challenges: Modern Management Strategies and Assisted Reproductive Technologies," addresses the growing global concern of infertility by exploring the latest clinical advancements, delving into modern diagnostic approaches for both male- and female-factor infertility.

The aim of this Special Issue is to provide a comprehensive overview of recent advances in assisted reproduction and to explore the challenges encountered at various stages of treatment. Topics include criteria for couples undergoing ART treatments or fertility preservation, assessment of ovarian reserve with new methods such as 3D antral follicle count, ovarian stimulation protocols (including dual trigger, dual stimulation, PPOS protocols, type and dose of gonadotropin, and pharmacogenomics), embryo transfer, and endometrial preparation—focusing on the window of implantation and endometrial receptivity (considering endometrial metabolism, immunology, and the microbiome)—culminating in pregnancy outcomes after IVF. Focus is placed on managing complex cases, including recurrent implantation failure and diminished ovarian reserve.

This Issue also examines time-lapse imaging for embryo selection, preimplantation genetic testing (PGT), and optimized cryopreservation techniques, such as vitrification.

By synthesizing evidence-based management strategies with technological innovations, this collection aims to provide clinicians and researchers with a comprehensive resource to improve patient counseling, treatment personalization, and, ultimately, clinical outcomes in reproductive medicine.

Dr. Luigi Carbone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infertility
  • assisted reproductive technologies (ARTs)
  • ovarian reserve
  • antral follicle count (AFC)
  • anti-mullerian hormone (AMH)
  • fertility preservation
  • IVF pregnancy
  • ovarian stimulation
  • embryo selection

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Other

12 pages, 367 KB  
Systematic Review
Letrozole Co-Administration in Progestin-Primed Ovarian Stimulation (PPOS) Protocols for Patients Undergoing In Vitro Fertilization: A Systematic Review
by Raffaella Di Girolamo, Maria Giuseppina Trinchillo, Luigi Vigilante, Roberta Ordichelli, Matteo Giudice, Giuseppe Gabriele Iorio, Ida Strina, Federica Cariati and Luigi Carbone
J. Clin. Med. 2026, 15(2), 410; https://doi.org/10.3390/jcm15020410 - 6 Jan 2026
Viewed by 103
Abstract
Objective: To systematically analyze and synthesize the evidence from the literature, we compared outcomes of the PPOS + LE protocol versus standard PPOS in patients undergoing IVF. Materials and Methods: We systematically searched the MEDLINE, Scopus, EMBASE, and Science Citation Index databases to [...] Read more.
Objective: To systematically analyze and synthesize the evidence from the literature, we compared outcomes of the PPOS + LE protocol versus standard PPOS in patients undergoing IVF. Materials and Methods: We systematically searched the MEDLINE, Scopus, EMBASE, and Science Citation Index databases to identify relevant studies. The clinical questions were developed according to the PICO framework. Quality assessment of the included studies was performed using the Newcastle–Ottawa Scale. Primary outcomes were ovarian stimulation outcomes (oocyte retrieved and mature oocytes). Secondary outcomes were hormonal levels during COS and pregnancy outcome. Results: Five retrospective studies compared oocyte yields between the PPOS and PPOS + LE protocols across diverse populations. While some authors reported significantly higher numbers of retrieved and mature oocytes with letrozole co-administration in a normal infertile population and in POSEIDON group 4, others found no benefit in the PCOS or POSEIDON 3 groups, indicating variable efficacy depending on patient characteristics. Conclusions: Incorporating letrozole counteracts the intense pituitary suppression typically associated with standard PPOS, increasing LH levels and the number of retrieved and mature oocytes in normal and poor responders, but not in PCOS women. Retrospective data do not allow for definitive conclusions to be drawn. Further studies are needed to confirm these results. Full article
Show Figures

Figure 1

Back to TopTop