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Special Issue Information

Dear Colleagues,

The early diagnosis of frontotemporal lobar degeneration (FTLD) and dementia with Lewy bodies (DLB) remains challenging as their clinical and pathological features overlap with Alzheimer’s disease and other types of dementia. The identification of clinical biomarkers is essential to improve the accuracy of diagnosis and the development of disease-modifying therapies.

This Special Issue of the Journal of Clinical Medicine aims to gather cutting-edge research to enhance our understanding of FTLD and DLB and pave the way to novel diagnostic and therapeutic strategies.

The following aspects of FTLD and DLB will be covered:

Clinical presentation;
Diagnosis;
Neuropathology;
Neuroimaging;
Biomarkers;
Management;
Disease-modifying therapies.

We look forward to receiving your original research and review articles.

Dr. Romina Vuono
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

dementia
FTLD
DLB
biomarkers
neuroimaging
differential diagnosis
therapy

Published Papers (1 paper)

Other

Open AccessCase Report

Combining Neuropsychological Assessment with Neuroimaging to Distinguish Early-Stage Alzheimer’s Disease from Frontotemporal Lobar Degeneration in Non-Western Tonal Native Language-Speaking Individuals Living in Taiwan: A Case Series

and

J. Clin. Med. 2023, 12(4), 1322; https://doi.org/10.3390/jcm12041322 - 07 Feb 2023

Viewed by 520

Abstract

Neuropsychological tests (NPTs), which are routinely used in clinical practice for assessment of dementia, are also considered to be essential for differential diagnosis of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD), especially the behavioral variants of frontotemporal dementia (bvFTD) and primary progressive aphasia (PPA) at their initial clinical presentations. However, the heterogeneous features of these diseases, which have many overlapping signs, make differentiation between AD and FTLD highly challenging. Moreover, NPTs were primarily developed in Western countries and for native speakers of non-tonal languages. Hence, there is an ongoing dispute over the validity and reliability of these tests in culturally different and typologically diverse language populations. The purpose of this case series was to examine which of the NPTs adjusted for Taiwanese society may be used to distinguish these two diseases. Since AD and FTLD have different effects on individuals’ brain, we combined NPTs with neuroimaging. We found that participants diagnosed with FTLD had lower scores in NPTs assessing language or social cognition than AD participants. PPA participants also had lower measures in the Free and Cued Selective Reminding Test than those diagnosed with bvFTD, while bvFTD participants showed poorer performances in the behavioral measures than PPA participants. In addition, the initial diagnosis was supported by the standard one-year clinical follow-up. Full article

(This article belongs to the Special Issue Recent Advances in the Clinical Diagnosis and Management of Frontotemporal Lobar Degeneration and Dementia with Lewy Bodies)

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