Special Issue "The Influence of Microbiota on Neuropathological Lesions"

Dear Colleagues,

The gut and its microbiota (MB-gut) is the largest absorption organ and reservoir of bacteria in the human body. The MB-gut is considered a single system whose interactions give rise to responses that affect the functions of the whole body. The central nervous system is in continuous cross-talk with the MB-gut in the so-called MB-gut–brain axis, and many bottom-to-top pathways activated by MB products are necessary for the correct development and physiological functions of the brain.

The dysregulation of this complex system is known to contribute to many pathological conditions in the general population. Elucidating how the MB-gut can affect the central nervous system in neurodegenerative pathologies such as Alzheimer’s and Parkinson’s disease, but also in other neurosurgical pathologies, such as gliomas and psychiatric disorders. Understanding the interactions between the MB-gut, the enteric system, immune cells, neurons and glia and their implications for host defense, tissue repair and neurodegeneration will be crucial to identifying new actors in the molecular basis of diseases.
In this regard, it is necessary to follow a multidisciplinary approach extended to all districts and components of the complex MB-gut–brain axis. In particular, the analysis of the MB-gut-driven alterations in the neuron–astrocyte–microglia triad will highlight neurodegenerative mechanisms related to the differential recruitment/activation of glial cells, will improve the knowledge of molecules involved in neurons/glia communication and elucidate MB-gut changes that could prevent and/or delay the pathology.In this regard, investigators are invited to contribute to this Special Issue with original research and review articles that can improve our understanding of the role of MB-gut–brain axis alteration not only in normal brain, but also in patients affected by neurodegenerative, neurosurgical and/or psychiatric diseases.

Dr. Andrea Cardia
Dr. Ismail Zaed
Guest Editors

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• gut microbiota
• microbiome
• neurosurgery
• neurodegeneration
• neuroinflammation
• glia–neuron interaction
• glioma
• neurodegenerative disorders
• neurosurgical disorders