Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
5.6
Journals
IJMS
Special Issues
State-of-the-Art Molecular Biophysics in Italy
ijms-logo
Submit to IJMS Review for IJMS

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

State-of-the-Art Molecular Biophysics in Italy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 4863

Special Issue Editor

Dr. Antonio Palumbo Piccionello

E-Mail Website
Collection Editor
Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche-STEBICEF, Università degli Studi di Palermo, Viale delle Scienze Ed. 17, 90128 Palermo, Italy
Interests: heterocyclic chemistry; drug design and synthesis; fluorinated organic compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Collection aims to publish contributions on all aspects of the physical principles governing biomolecular and biomimetic systems in Italy. We welcome submissions that provide novel and mechanistic insights and papers that report significant advances in the fields. Topics include, but are not limited to:

  • molecular structure;
  • molecular simulations
  • single molecule biophysics;
  • drug design;
  • bio-inspired drug

The only limitation is that the main part of the study has to have been carried out in Italy or by Italian researchers.

The reliability of the results provided by novel tools for virtual screening and/or the discovery of new actives by virtual screening must be either validated in silico or in vitro before first submission of a manuscript to IJMS. Theoretical studies should offer new insights into understanding experimental results and/or suggest new experimentally testable hypotheses.

Prof. Dr. Antonio Palumbo Piccionello
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular structure
  • molecular simulations
  • molecule biophysics
  • drug design
  • bio-inspired drug
  • biomimetic systems

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

15 pages, 3252 KiB  
Article
Playing with Biophysics: How a Symphony of Different Electromagnetic Fields Acts to Reduce the Inflammation in Diabetic Derived Cells
by Federica Zanotti, Martina Trentini, Ilaria Zanolla, Elena Tiengo, Chiara Mantarro, Luca Dalla Paola, Elena Tremoli, Maria Sambataro, Luisa Sambado, Massimo Picari, Sara Leo, Letizia Ferroni and Barbara Zavan
Int. J. Mol. Sci. 2023, 24(2), 1754; https://doi.org/10.3390/ijms24021754 - 16 Jan 2023
Cited by 7 | Viewed by 1918
Abstract
Several factors, such as ischemia, infection and skin injury impair the wound healing process. One common pathway in all these processes is related to the reactive oxygen species (ROS), whose production plays a vital role in wound healing. In this view, several strategies [...] Read more.
Several factors, such as ischemia, infection and skin injury impair the wound healing process. One common pathway in all these processes is related to the reactive oxygen species (ROS), whose production plays a vital role in wound healing. In this view, several strategies have been developed to stimulate the activation of the antioxidative system, thereby reducing the damage related to oxidative stress and improving wound healing. For this purpose, complex magnetic fields (CMFs) are used in this work on fibroblast and monocyte cultures derived from diabetic patients in order to evaluate their influence on the ROS production and related wound healing properties. Biocompatibility, cytotoxicity, mitochondrial ROS production and gene expression have been evaluated. The results confirm the complete biocompatibility of the treatment and the lack of side effects on cell physiology following the ISO standard indication. Moreover, the results confirm that the CMF treatment induced a reduction in the ROS production, an increase in the macrophage M2 anti-inflammatory phenotype through the activation of miRNA 5591, a reduction in inflammatory cytokines, such as interleukin-1 (IL-1) and IL-6, an increase in anti-inflammatory ones, such as IL-10 and IL-12 and an increase in the markers related to improved wound healing such as collagen type I and integrins. In conclusion, our findings encourage the use of CMFs for the treatment of diabetic foot. Full article
(This article belongs to the Special Issue State-of-the-Art Molecular Biophysics in Italy)
►▼ Show Figures

Figure 1

14 pages, 1953 KiB  
Article
A Global Picture of Molecular Changes Associated to LPS Treatment in THP-1 Derived Human Macrophages by Fourier Transform Infrared Microspectroscopy
by Diletta Ami, Ana Rita Franco, Valentina Artusa, Paolo Mereghetti, Francesco Peri and Antonino Natalello
Int. J. Mol. Sci. 2022, 23(21), 13447; https://doi.org/10.3390/ijms232113447 - 03 Nov 2022
Cited by 1 | Viewed by 1405
Abstract
Macrophages are among the first immune cells involved in the initiation of the inflammatory response to protect the host from pathogens. THP-1 derived macrophages (TDM) are used as a model to study the pro-inflammatory effects of lipopolysaccharide (LPS) exposure. Intact TDM cells were [...] Read more.
Macrophages are among the first immune cells involved in the initiation of the inflammatory response to protect the host from pathogens. THP-1 derived macrophages (TDM) are used as a model to study the pro-inflammatory effects of lipopolysaccharide (LPS) exposure. Intact TDM cells were analysed by Fourier transform infrared (FTIR) microspectroscopy, supported by multivariate analysis, to obtain a snapshot of the molecular events sparked by LPS stimulation in macrophage-like cells. This spectroscopic analysis enabled the untargeted identification of the most significant spectral components affected by the treatment, ascribable mainly to lipid, protein, and sulfated sugar bands, thus stressing the fundamental role of these classes of molecules in inflammation and in immune response. Our study, therefore, shows that FTIR microspectroscopy enabled the identification of spectroscopic markers of LPS stimulation and has the potential to become a tool to assess those global biochemical changes related to inflammatory and anti-inflammatory stimuli of synthetic and natural immunomodulators different from LPS. Full article
(This article belongs to the Special Issue State-of-the-Art Molecular Biophysics in Italy)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

24 pages, 5220 KiB  
Review
Exploring Reliable and Efficient Plasmonic Nanopatterning for Surface- and Tip-Enhanced Raman Spectroscopies
by Antonio Sasso, Angela Capaccio and Giulia Rusciano
Int. J. Mol. Sci. 2023, 24(22), 16164; https://doi.org/10.3390/ijms242216164 - 10 Nov 2023
Viewed by 839
Abstract
Surface-enhanced Raman scattering (SERS) is of growing interest for a wide range of applications, especially for biomedical analysis, thanks to its sensitivity, specificity, and multiplexing capabilities. A crucial role for successful applications of SERS is played by the development of reproducible, efficient, and [...] Read more.
Surface-enhanced Raman scattering (SERS) is of growing interest for a wide range of applications, especially for biomedical analysis, thanks to its sensitivity, specificity, and multiplexing capabilities. A crucial role for successful applications of SERS is played by the development of reproducible, efficient, and facile procedures for the fabrication of metal nanostructures (SERS substrates). Even more challenging is to extend the fabrication techniques of plasmonic nano-textures to atomic force microscope (AFM) probes to carry out tip-enhanced Raman spectroscopy (TERS) experiments, in which spatial resolution below the diffraction limit is added to the peculiarities of SERS. In this short review, we describe recent studies performed by our group during the last ten years in which novel nanofabrication techniques have been successfully applied to SERS and TERS experiments for studying bio-systems and molecular species of environmental interest. Full article
(This article belongs to the Special Issue State-of-the-Art Molecular Biophysics in Italy)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop