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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Immune Microenvironment and Tissue Remodeling in Oral Diseases and Oral Cancer

edited by

Aiman Ali

submission deadline 30 Mar 2026 | Viewed by 107 | Submission Open

Keywords: immune microenvironment; oral cancer; oral diseases; tissue remodeling; molecular signaling pathways

(This special issue belongs to the Section Molecular Immunology)

Research on Stress Signaling in Embryonic Development

edited by

Poongodi Geetha-Loganathan

and Norihisa Higashihori

submission deadline 30 Mar 2026 | Viewed by 103 | Submission Open

Keywords: stress signaling; embryonic development; morphogenesis; signal transduction; teratogenesis

(This special issue belongs to the Section Molecular Biology)

Nitrogen-Containing Heterocycles and Their Biological Applications

edited by

Stella Manta

submission deadline 30 Mar 2026 | Viewed by 93 | Submission Open

Keywords: nitrogen-based heterocycles; synthesis; pharmaceuticals; biological activities

(This special issue belongs to the Section Biochemistry)

Down Syndrome: From Molecular Mechanisms to Therapeutic Strategies

edited by Amy Feldman Lewanda

submission deadline 30 Mar 2026 | Viewed by 82 | Submission Open

Keywords: down syndrome; Trisomy 21; molecular mechanisms; therapeutic strategies; neurodegeneration; comorbidities; animal models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research of Emerging Mechanisms in Neuronal Signaling

edited by Dongshu Du

submission deadline 30 Mar 2026 | Viewed by 78 | Submission Open

Keywords: neuronal signaling; astrocytes and microglia; extracellular vesicles; ephaptic coupling; tunneling nanotubes; primary cilium; local mRNA translation; cognition; behavior; physiology; psychiatry

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Pathophysiology of Nerve Regeneration

edited by Fabian Szepanowski and Mark Stettner

submission deadline 30 Mar 2026 | Viewed by 77 | Submission Open

Keywords: nerve injury; nerve inflammation; autoimmune neuropathies; immune-mediated neuropathies; polyneuropathies; peripheral neuroinflammation; nerve regeneration; Schwann cell; Schwann cell differentiation; repair Schwann cell

(This special issue belongs to the Section Molecular Neurobiology)

Updates on Metal Ions and Related Complexes in Molecular Biology and Biochemistry

edited by

Makan Golizeh

submission deadline 30 Mar 2026 | Viewed by 77 | Submission Open

Keywords: biochemistry; homeostasis; metal ions; metal ion complexes; metallomics; molecular biology; molecular pathogenesis; quantification; systems biology; toxicity

(This special issue belongs to the Section Biochemistry)

Advances in Animal Molecular Genetics

edited by

Jarosław Króliczewski

submission deadline 30 Mar 2026 | Viewed by 72 | Submission Open

Keywords: epigenetics; functional genomics; gene expression; gene polymorphism; genetic diseases; genetic techniques and assays; genome-wide association; genetic markers; quantitative genetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Precision Targets for Brain Health: The Molecular Era of Neuropharmacology

edited by

Terezia Kiskova-Simkova

submission deadline 30 Mar 2026 | Viewed by 68 | Submission Open

Keywords: neurology; neuropharmacology; molecular targets; biomarker; personalized medicine

(This special issue belongs to the Section Molecular Neurobiology)

Microbial Biofilms in Health and Disease: Molecular Perspectives

edited by

Paweł Krzyżek

submission deadline 30 Mar 2026 | Viewed by 68 | Submission Open

Keywords: biofilm; antibiofilm; biofilm matrix; matrixome; antibiotic resistance; antibiotic tolerance

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Melanoma Resistance to Targeted Therapy

edited by

Ignacija Vlasic

and

Anđela Horvat

submission deadline 30 Mar 2026 | Viewed by 65 | Submission Open

Keywords: melanoma; targeted therapy; mechanisms of therapy resistance; predictive biomarkers

(This special issue belongs to the Section Molecular Oncology)

Current Advances in Immuno-Oncology

edited by Gratiela Grădișteanu Pircălabioru

submission deadline 30 Mar 2026 | Viewed by 50 | Submission Open

Keywords: immuno-oncology; tumor microenvironment; immune checkpoint inhibitors; CAR-T cells; adoptive cell therapy; cancer vaccines; oncolytic viruses; tumor immune evasion; immunometabolism; biomarkers; tumor immunology; microbiome and cancer

(This special issue belongs to the Section Molecular Oncology)

Functional (Pharmaco) Genomics and Genetics in Atrial Fibrillation Associated with Sudden Cardiac Death Syndromes

edited by

Hector Barajas-Martinez

and

Anthony Ashton

submission deadline 30 Mar 2026 | Viewed by 41 | Submission Open

Keywords: atrial fibrillation; sudden cardiac death syndromes; channelopathies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Omics Approaches to Decipher Inborn Errors of Immunity and Secondary Immunodeficiencies

edited by

Francesco Saettini

submission deadline 30 Mar 2026 | Viewed by 39 | Submission Open

Keywords: inborn errors of immunity; primary immunodeficiency; secondary immunodeficiency; omics; genomics; proteomics; metabolomics; transcriptomics; lipidomics; single-cell; spatial transcriptomics; immune dysregulation

(This special issue belongs to the Section Molecular Immunology)

Metabolic Dysfunction-Associated Steatotic Liver Disease: From Basic Science to Therapy

edited by

Łukasz Bułdak

submission deadline 31 Mar 2026 | 5 articles | Viewed by 13508 | Submission Open

Keywords: MASLD; liver steatosis; steatohepatitis; liver cirrhosis; hepatocellular carcinoma; in vivo; in vitro; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances on Cannabinoid and Endocannabinoid Research, 3rd Edition

edited by

Rosaria Meccariello

submission deadline 31 Mar 2026 | 4 articles | Viewed by 8416 | Submission Open

Keywords: cannabinoid; endocannabinoid; cannabinoid receptor; endogenous cannabinoid; pharmacological research

(This special issue belongs to the Section Molecular Pharmacology)

Unravelling the Intricate Link Between Microvascular Dysfunction and Cardiovascular Disease

edited by Róbert Pórszász

submission deadline 31 Mar 2026 | 1 articles | Viewed by 4260 | Submission Open

Keywords: microvascular dysfunction; cardiovascular pathogenesis; endothelial dysfunction; oxidative stress; nitric oxide bioavailability; VEGF dysregulation; endothelin-1 overactivity; heart failure with preserved ejection fraction (HFpEF); pharmacological interventions; microcirculation-targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Vitamin D in Human Health and Diseases, 5th Edition

edited by

Loredana Bergandi

and

Francesca Silvagno

submission deadline 31 Mar 2026 | 3 articles | Viewed by 4020 | Submission Open

Keywords: vitamin D; vitamin D receptor; calciferol; health; disease; inflammation; gene transcription; cell metabolism; differentiation; vitamin D deficiency; vitamin D supplementation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Role of Bioactive Compounds in Human Health and Disease: 3rd Edition

edited by

Guan-Jhong Huang

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3697 | Submission Open

Keywords: cancer; inflammation; cardiovascular diseases; plants; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Genetics and Breeding Research in Horticultural Crops

edited by

Hui Zhang

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3060 | Submission Open

Keywords: horticultural crops; genomic sequencing; multi-omics technologies; molecular biology; gene editing; plant breeding; function of genes; molecular marker

(This special issue belongs to the Section Molecular Plant Sciences)

Ion Transporters and Channels

edited by

Yoshinori Marunaka

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2619 | Submission Open

Keywords: ion transporter; ion channel; proton; interstitial fluid pH; Na+ channels; K+ channels; Cl− channels; ENaC; CALHM

(This special issue belongs to the Section Biochemistry)

Molecular Underpinnings of Schizophrenia Spectrum Disorders, 2nd Edition

edited by

Paola Rocca

and

Claudio Brasso

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1506 | Submission Open

Keywords: schizophrenia spectrum disorders; central nervous system (CNS); psychotic disorders

(This special issue belongs to the Section Molecular Neurobiology)

Mechanism Research on Listeria monocytogenes and Its Control

edited by

Irene Martín Tornero

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1370 | Submission Open

Keywords: Listeria monocytogenes; virulence; biofilm; pathogenicity; control; prevention; food safety

(This special issue belongs to the Section Molecular Microbiology)

ROS and Abiotic Stress in Plants, 3rd Edition

edited by

Tsanko S. Gechev

and

Veselin Petrov

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1239 | Submission Open

Keywords: chilling and freezing; drought stress; heat stress; heavy metals stress; nutrient and mineral stress; oxidative stress; resurrection plants and desiccation tolerance; salinity

(This special issue belongs to the Section Molecular Plant Sciences)

Amyloid Hetero-Aggregation: 2nd Edition

edited by

Ludmilla A. Morozova-Roche

submission deadline 31 Mar 2026 | Viewed by 1238 | Submission Open

Keywords: amyloid; co-aggregation; hetero-aggregation; human proteins; bacterial amyloids; viral proteins; cytotoxicity; structure; function

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ferroptosis, ROS and Cell Death Cytomodulator Compounds

edited by Alireza Valanezhad

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1140 | Submission Open

Keywords: cell death; ferroptosis; ROS; GPX4; lipid peroxidation; inhibitors; inducers; cytomodulator compounds; cancer; disease; bone formation

(This special issue belongs to the Section Biochemistry)

Advanced Molecular Mechanism of Pathogenesis of Osteoarthritis

edited by Takako Hattori

submission deadline 31 Mar 2026 | 1 articles | Viewed by 919 | Submission Open

Keywords: osteoarthritis; degeneration of cartilage; mechanical loading; senescence; cell cycle; cellular communication network family member 3 (CCN3)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Epigenetics and RNA Processing Involved in Disease

edited by

Naoyuki Kataoka

submission deadline 31 Mar 2026 | 1 articles | Viewed by 900 | Submission Open

Keywords: RNA processing; RNA splicing; epigenetics; DNA modification; histone modification; RNA modification; RNA diseases; genetic diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Computational Studies of Natural Products

edited by

Leonid B. Krivdin

submission deadline 31 Mar 2026 | Viewed by 692 | Submission Open

Keywords: computational chemistry; natural products; structural elucidation; Nuclear Magnetic Resonance (NMR); Density Functional Theory (DFT)

(This special issue belongs to the Section Molecular Informatics)

Early Molecular Markers of Neurodegeneration

edited by

Eduard Korkotian

and

Michele Papa

submission deadline 31 Mar 2026 | Viewed by 655 | Submission Open

Keywords: neuronal loss; synaptic loss; synaptic alterations; exosomes

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Genetic Research in Skin Diseases

edited by

Yiannis Vasilopoulos

submission deadline 31 Mar 2026 | Viewed by 625 | Submission Open

Keywords: inflammatory skin diseases; genome-wide association studies (GWAS); epigenetic modifications; multi-omic integration; precision dermatology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Laboratory Animal Research for Precision Medicine in Cardiovascular Diseases

edited by Conrado Calvo

submission deadline 31 Mar 2026 | Viewed by 583 | Submission Open

Keywords: cardiovascular disease; experimental models and research; arrhythmias and cardiac electrophysiology; molecular science and imaging techniques; myocardial ischemia and heart failure; cardiac fibrillation and sudden cardiac death; circulation and blood vessels; diabetes and metabolic disorders; experimental datasets for precision medicine; data-driven in silico approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational and Molecular Advances in Precision Craniofacial Medicine

edited by

Hsiu-Hsia Lin

submission deadline 31 Mar 2026 | Viewed by 575 | Submission Open

Keywords: precision medicine; craniofacial anomalies; artificial intelligence; 3D morphometrics; genomics; transcriptomics; computational modeling; phenotype– genotype correlation; craniofacial surgery; tissue engineering

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Flow Cytometry as a Tool for Diagnostics and Biomarker Research

edited by

Leslie Chavez-Galan

submission deadline 31 Mar 2026 | Viewed by 563 | Submission Open

Keywords: biomarkers; flow cytometry; spectral cytometry; mass cytometry; translational research; human health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Bioinformatics and Multi-Omics Applications in Cancer Research

edited by Yang Shi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 562 | Submission Open

Keywords: bioinformatics; genomics; transcriptomics; epigenomics; proteomics; metabolomics; multi-omics; cancer research; machine learning; biomarker discovery

(This special issue belongs to the Section Molecular Informatics)

Targeting Autophagy Pathways for Cancer Treatment

edited by

Maryam Zarghooni

submission deadline 31 Mar 2026 | Viewed by 556 | Submission Open

Keywords: tumor microenvironment; metabolic reprogramming; tumor immunity; metabolic adaptation; autophagy pathways

(This special issue belongs to the Section Molecular Oncology)

Novel Natural Compound for Wound and Tissue Repair and Regeneration: 4th Edition

edited by

Elia Ranzato

submission deadline 31 Mar 2026 | 1 articles | Viewed by 553 | Submission Open

Keywords: wound repair; tissue regeneration; natural compounds; phytochemicals; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Cellular Mechanisms in Cardiovascular Disease

edited by

Paul Meakin

submission deadline 31 Mar 2026 | Viewed by 520 | Submission Open

Keywords: vascular cell function; atherosclerosis; diabetes-associated vascular complications; hypertension

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurological Diseases: From Pathogenesis to Molecular Diagnosis and Treatment

edited by

Barbara Miziak

and

Stanisław Jerzy Czuczwar

submission deadline 31 Mar 2026 | 1 articles | Viewed by 492 | Submission Open

Keywords: Alzheimer's disease; Parkinson's disease; Huntington's disease; epilepsy; stroke; neurological diseases; treatment of neurological diseases

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Aspects of Cancer Stem Cell Biology and Their Therapeutic Implications

edited by

Tanja Matijevic Glavan

submission deadline 31 Mar 2026 | 1 articles | Viewed by 457 | Submission Open

Keywords: cancer stem cells; chemotherapy; radiotherapy; transcription factors; stemness properties; chemoresistance; radioresistance

(This special issue belongs to the Section Molecular Oncology)

Materials for Photobiology—3rd Edition

edited by

Enrico Caruso

Antonino Mazzaglia

and

Angela Scala

submission deadline 31 Mar 2026 | Viewed by 450 | Submission Open

Keywords: light-responsive materials; phototherapeutics; photodiagnosis; bioimaging; living bioluminescent materials; light-induced therapy; UV-radiation effect; photo-antinfective materials; photosensory biology; molecular optogenetics

(This special issue belongs to the Section Materials Science)

Advances in Vaccine Immunology

edited by

Michael Eller

submission deadline 31 Mar 2026 | 1 articles | Viewed by 437 | Submission Open

Keywords: vaccine-induced immunity; systems vaccinology; single-cell immune profiling; multiomics; correlates of Protection; innate immunity; adjuvants; artificial Intelligence; immunomodulation; tissue-specific immune activation

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Fruit Crops Development

edited by

Xingguo Li

submission deadline 31 Mar 2026 | Viewed by 436 | Submission Open

Keywords: fruit crops; fruit tree; proteomics; genomics; metabolomics; biotic stress; abiotic stress

(This special issue belongs to the Section Molecular Plant Sciences)

Therapeutic Advances in Multiple Sclerosis

edited by Arturo Mangas and

Rafael Coveñas Rodríguez

submission deadline 31 Mar 2026 | Viewed by 407 | Submission Open

Keywords: multiple sclerosis; neurodegenerative disease; chronic disease; autoimmune disease; biological markers; new drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Cytokines in Immunological Disorders and Their Therapies

edited by

Mohammad Massumi

submission deadline 31 Mar 2026 | Viewed by 387 | Submission Open

Keywords: cytokines; autoimmune diseases; autoinflammatory diseases; TNF-alpha; interleukin-17; IL-6; immune tolerance; biologic therapy; JAK inhibitors; inflammation

(This special issue belongs to the Section Molecular Immunology)

Advances in Lipedema: Pathophysiology, Prevention and Treatments

edited by Angelika Chachaj

submission deadline 31 Mar 2026 | Viewed by 307 | Submission Open

Keywords: lipedema; microvascular dysfunction; inflammation; lipedema diagnosis; biomarkers; diet in lipedema; quality of life; compression therapy; liposuction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathologies and Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome—2nd Edition

edited by

Elisa Oltra

submission deadline 31 Mar 2026 | Viewed by 235 | Submission Open

Keywords: myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); diagnosis; post-exertional malaise (PEM); comorbidity; biomarker; therapy; immunity; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Amino Acid Nutrition and Human Health

edited by

Terrence Piva

submission deadline 31 Mar 2026 | Viewed by 229 | Submission Open

Keywords: amino acids; dietary intake; metabolic disease; starvation; obesity; supplementation; parental nutrition; gene expression; tumour metabolism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Traditional Foods: Bioactive Compounds, Gut Microbiota Modulation, and Health Outcomes

edited by