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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Evolution and Genomics: Relevance to Current Issues
edited by and Sally Lloyd
submission deadline 20 May 2026 | 2 articles | Viewed by 3692 | Submission Open
Keywords: paralogy; synteny; evolution; genomics; duplication; haplotype
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in Dementia with Lewy Bodies and Alzheimer’s Disease
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 3407 | Submission Open
Keywords: dementia with Lewy bodies; Alzheimer’ s disease; dementing disorders in advanced age
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Characterization of Plant–Microbe Interactions submission deadline 20 May 2026 | 3 articles | Viewed by 3376 | Submission Open
Keywords: phytopathogen; plant pathology; phytopathogen fungi; phytopathogen bacteria; phytoalexins; plant defense; allelopathy; fungicides
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Diagnostics in Neurological Diseases submission deadline 20 May 2026 | 2 articles | Viewed by 3345 | Submission Open
Keywords: neurological diseases; biomarkers; translational research; precision medicine; diagnosis; prognosis
(This special issue belongs to the Section Molecular Neurobiology)
Thermodynamic and Spectral Studies of Complexes
edited by Michał Zabiszak
submission deadline 20 May 2026 | 4 articles | Viewed by 3331 | Submission Open
Keywords: spectroscopic techniques; molecular interaction; electronic spectroscopy; solid state chemistry; applications of complex compounds; reaction mechanism; catalytic activity
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Prostate Diseases: Focus on Hormone Therapies and Targeted Interventions
edited by Gabriel Campolina-Silva and Héctor Contreras
submission deadline 20 May 2026 | 1 articles | Viewed by 3301 | Submission Open
Keywords: urinary disease; prostate cancer; hormone; therapeutic strategy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cyclodextrins for Drug/iRNA Co-Delivery
edited by and
submission deadline 20 May 2026 | 1 articles | Viewed by 3254 | Submission Open
Keywords: advanced therapies; antibody-based therapies; active and passive tumor targeting; cancer; conventional chemotherapy; immune system; immunotherapy; immunotoxicity; nanomedicine; nanoparticles; nanotoxicity; tumor immune microenvironment (TIME); tumor microenvironment (TME); cyclodextrins
(This special issue belongs to the Section Macromolecules)
Whole-Cell System and Synthetic Biology, 2nd Edition
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 3240 | Submission Open
Keywords: synthesis biology; molecular biology; functional nucleic acids; biosensor; CRISPR-Cas; directed evolution; whole-cell system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomedical Polymer Materials: Design, Synthesis or Applications
edited by Lourdes Franco
submission deadline 20 May 2026 | 1 articles | Viewed by 3211 | Submission Open
Keywords: biomedical polymeric materials; nanoparticles; drug delivery; smart materials; hydrogels; tissue regeneration; therapeutic applications; dendrimers; MOFs; micelles
(This special issue belongs to the Section Materials Science)
RNA Editing/Modification in Health and Disease
edited by Valeriana Cesarini and
submission deadline 20 May 2026 | 2 articles | Viewed by 3204 | Submission Open
Keywords: RNA editing; RNA transport and localization; miRNAs; siRNAs; lncRNAs
(This special issue belongs to the Section Molecular Genetics and Genomics)
Peptides and Peptidomimetics for Targeting Protein-Protein Interactions submission deadline 20 May 2026 | 1 articles | Viewed by 3191 | Submission Open
Keywords: protein– protein interactions; peptide– protein interactions; interactome; proteomics; peptides; modified peptides; peptidomimetics; molecular glues; drug discovery; medicinal chemistry; rule of five; biophysical assays; molecular modelling; cancer; neurodegenerative diseases; orphan diseases; antimicrobial resistance; PROTAC
(This special issue belongs to the Section Biochemistry)
Molecular Insights into Flower Gene Regulation
edited by Wen‑Chieh Tsai
submission deadline 20 May 2026 | 2 articles | Viewed by 3070 | Submission Open
Keywords: floral gene regulation; flowers; homeotic genes; MADSBox; pollination
(This special issue belongs to the Section Molecular Plant Sciences)
The Molecular Basis of Extracellular Vesicles in Health and Diseases—2nd Edition
edited by Taral R. Lunavat
submission deadline 20 May 2026 | 3 articles | Viewed by 2889 | Submission Open
Keywords: exosomes; microvesicles; extracellular vesicles; genetic material; therapeutics; diagnostics; biomarkers; molecular pathway; liquid biopsy; metabolism; omics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Medical Applications of Polymer Materials
edited by Zhen Zhang
submission deadline 20 May 2026 | 2 articles | Viewed by 2853 | Submission Open
Keywords: medical polymers; drug delivery; tissue engineering; medical devices; diagnostics
(This special issue belongs to the Section Macromolecules)
The Roles of Diet and Nutrition in Metabolic Diseases: Advancements in Molecular Insights
edited by Ramos-López Omar
submission deadline 20 May 2026 | 2 articles | Viewed by 2796 | Submission Open
Keywords: diet; nutrition; metabolic diseases; obesity; genetics; microbiota; epigenetics; metabolomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Lymphedema: From Mechanism to Treatment
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 2677 | Submission Open
Keywords: lymphedema; lymphatic dysfunction; molecular mechanisms; cell signaling; diagnostic imaging; biomarkers; therapeutic interventions; inflammation; adipose tissue accumulation; fibrosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Liver Diseases: Causes, Molecular Mechanism and Treatment/Prevention
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 2658 | Submission Open
Keywords: liver diseases; pathophysiology; molecular mechanisms; genetics and epigenetics; non-alcoholic fatty liver disease (NAFLD); hepatitis; liver injury and repair; gene therapy; pharmacological interventions; treatment and prevention; gut– liver axis; spleen– liver axis; alcoholic liver disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Molecular Science Through Reproducible qPCR: MIQE Guidelines and Beyond
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 2625 | Submission Open
Keywords: MIQE; qPCR; reverse transcription
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomarkers in Diabetes Mellitus: From Discovery to Clinical Application submission deadline 20 May 2026 | 2 articles | Viewed by 2576 | Submission Open
Keywords: diabetes mellitus; biomarkers; diabetes complications; omics technologies; risk stratification; therapeutic response; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Food Compounds in the Prevention and Treatment of Non-Communicable Diseases
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 2536 | Submission Open
Keywords: bioactive compounds; dietary fiber; polyphenols; sulfur compounds; antioxidant; reduce oxidative stress; inflammation; non-communicable diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Glial Cells in Neurodegenerative Disorders
edited by Daniel Souza Monteiro de Araujo
submission deadline 20 May 2026 | 2 articles | Viewed by 2520 | Submission Open
Keywords: glial cells; microglia; astrocytes; oligodendrocytes; neurodegenerative disorders
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Advances in the Synthesis and Medical Application of Biomaterials
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 2444 | Submission Open
Keywords: nanostructured biomaterials; bioceramics; bioactive; biodegradable; resorbable materials; biomimetic materials; biocompatibility
(This special issue belongs to the Section Materials Science)
Molecular Computational Research in Pharmacological Structure–Efficacy
edited by and Jerônimo Lameira
submission deadline 20 May 2026 | 2 articles | Viewed by 2420 | Submission Open
Keywords: molecular modeling; structure– activity relationship (SAR); pharmacological efficacy; quantum chemistry; molecular dynamics; free energy calculations; drug design; enzyme inhibition; ligand– receptor interactions; computational pharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Cell Organelle Stress Responses and Implications in Human Diseases
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 2281 | Submission Open
Keywords: organelle stresses; mitochondria; ER; lysosome; human diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Targets in Cardiovascular Health and Cardiotoxicity
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 2265 | Submission Open
Keywords: cardiovascular; ischemia; heart failure; arrhythmogenesis; myocardial remodeling; endothelial dysfunction; cardiology; cardio-oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Insights into Glycobiology submission deadline 20 May 2026 | 2 articles | Viewed by 2252 | Submission Open
Keywords: glycosylation; biomarkers; separation techniques; mass spectrometry; multivariate data analysis
(This special issue belongs to the Section Molecular Biology)
Advancing Interdisciplinary Science with Quantum/Molecular Mechanics (QM/MM) in Computational Chemistry
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 2231 | Submission Open
Keywords: QM/MM; computational methods; electronic structure; f-electron systems; materials science; nanoclusters; nuclear medicine; computational catalysis; drug design; machine learning in computational chemistry
(This special issue belongs to the Section Materials Science)
Recent Advances in Graphene-Based Nanocomposites and Perspectives on Their Design
edited by Aleksey E. Kuznetsov
submission deadline 20 May 2026 | 2 articles | Viewed by 2186 | Submission Open
Keywords: graphene; graphene oxide; nanocomposite; synthesis; computational study; characterization; application; design
(This special issue belongs to the Section Molecular Nanoscience)
Life’s Thermodynamics: Cells and Evolution
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 2167 | Submission Open
Keywords: cell growth and decay; cell aging; system biology; mathematical modeling; ecological modeling; dissipative adaptation; maximum power principle; evolution of microbial fitness; energy balance in microbial cultures
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Emerging Biomaterials for Cartilage Regeneration
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 2029 | Submission Open
Keywords: osteoarthritis; glycosaminoglycans; biomaterials; cartilage regeneration; mesenchymal cells; chondrocytes
(This special issue belongs to the Section Biochemistry)
Next-Generation Hydrogels: Innovations in Biofunctionalization and Personalization for Targeted Biomedical Therapies
edited by and Bohan Yin
submission deadline 20 May 2026 | 1 articles | Viewed by 2013 | Submission Open
Keywords: biofunctionalization hydrogels; personalized hydrogels; smart hydrogel development; 3D/4D bioprinting of hydrogels; AI-driven hydrogel design; dynamic hydrogel systems; hydrogel-based vaccines and immunotherapies; smart hydrogels for controlled release
(This special issue belongs to the Section Macromolecules)
Cancer-Driving Molecules: From Molecular Mechanisms to Novel Therapeutics
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 1987 | Submission Open
Keywords: cancer; mechanism of action; tumor microenvironment; immune system; DNA/RNA/protein; small-molecule probes; activation/inhibition; biological activity
(This special issue belongs to the Section Molecular Oncology)
The Role of Lipoprotein in Cardiovascular Disease submission deadline 20 May 2026 | 1 articles | Viewed by 1910 | Submission Open
Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antiviral Drug Targets: Structure, Function, and Drug Design—3rd Edition
edited by and
submission deadline 20 May 2026 | 2 articles | Viewed by 1795 | Submission Open
Keywords: viral infections; drug design; protein structures; functional studies; viruses; antiviral drugs
(This special issue belongs to the Section Molecular Pharmacology)
Antisense Oligonucleotides: Versatile Tools with Broad Applications
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 1716 | Submission Open
Keywords: antisense oligonucleotide; RNase H; splice switching; exon skipping; therapeutics; pesticide
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Pathophysiology of Myocardial Disease, 2nd Edition
edited by , and Hongyu Qiu
submission deadline 20 May 2026 | 1 articles | Viewed by 1683 | Submission Open
Keywords: myocardial disease; cardiomyopathy; fibrosis and remodeling; inflammation; hypertension; heart failure; cardiometabolic; cardio-renal; heart-liver axis; comorbidity; molecular mechanisms; pathophysiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antimicrobial Agents: Synthesis and Design
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1668 | Submission Open
Keywords: multi-drug resistant Gram-negative and Gram-positive pathogens; clinically relevant superbugs; severe and almost untreatable infections; immunocompromised individuals; synthetic antimicrobial cationic macromolecules; synthetic cationic dendrimers; polymers; and copolymers; polymerizing strategies; quaternary ammonium and phosphonium salts; amino-acid modified macromolecules; electrostatic interactions and membrane permeabilization; membrane disruptors; drug delivery systems; cationic bola-amphiphiles
(This special issue belongs to the Section Molecular Microbiology)
Colorectal Cancers: New Approach to Their Pathology, Diagnosis and Therapy
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 1625 | Submission Open
Keywords: occult blood test; colorectal cancer; colonoscopy; rectal bleeding; abdominal pain; hemicolectomy; novel oncological drugs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Genomics Advances in Behaviours
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1617 | Submission Open
Keywords: unhealthy and healthy behaviors; smoking; sleeping; eating; alcoholism; gambling; aggression; addictive behaviors; physical activity; mental disorders
(This special issue belongs to the Section Molecular Biology)
New Advances of Free-Radical Reactions in Organic Chemistry
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1597 | Submission Open
Keywords: free-radical reactions; organic chemistry; organic synthesis; fotoredox reactions; organometallics reactions; computational calculations; free radicals in biology; free radicals in green chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Advances and Mechanisms in Breast Cancer—2nd Edition
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 1583 | Submission Open
Keywords: breast cancer; genes and molecular pathways; targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Treatment in Gastrointestinal Cancers
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1579 | Submission Open
Keywords: gastrointestinal cancers; tumor microenvironment; immune regulation; biomarkers; therapeutic resistance; liquid biopsy; targeted therapy; immune checkpoint inhibitors; epigenetic regulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Osteoblast Differentiation in Human Health and Disease
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1566 | Submission Open
Keywords: osteoblast differentiation; bone remodeling; mesenchymal stem cells; skeletal diseases; osteogenesis; bone mineralization; osteoporosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Novel Therapeutic Strategies for Cancers submission deadline 20 May 2026 | 1 articles | Viewed by 1549 | Submission Open
Keywords: precision medicine; molecular targeted therapies; kinase inhibitors; PROTAC; CAR-T cell therapy; tumor microenvironment; host microbiota; resistance mechanisms; biomarkers; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Applications of Phytochemicals in Drug Synthesis
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1546 | Submission Open
Keywords: natural products; phytochemistry; chemical synthesis; drugs; medicinal plants; natural sources; byproducts
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Molecular Progression of Movement Disorders submission deadline 20 May 2026 | 1 articles | Viewed by 1513 | Submission Open
Keywords: movement disorders; molecular mechanisms; neurodegenerative diseases; therapeutic targets; biomarkers; neuroinflammation; protein misfolding; mitochondrial dysfunction; environmental factors; genetic factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Glycobiology: The New Discoveries, Approaches, and Technical Developments: 2nd Edition
edited by Sanja Dabelić
submission deadline 20 May 2026 | 2 articles | Viewed by 1513 | Submission Open
Keywords: glycans; lectins; glycoconjugates; glycosylation; genetic disorders of glycosylation; glycomics and glycoproteomics
(This special issue belongs to the Section Macromolecules)
New Research on Bioactive Natural Products: 2nd Edition submission deadline 20 May 2026 | 1 articles | Viewed by 1511 | Submission Open
Keywords: chronic disorders; bioactives; natural sources; sustainable sources; biomolecular; structure– activity relationship; synergism; health promoting; bio-functional; products; supplements; nutraceuticals; drugs
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Insights into Kidney Diseases—2nd Edition
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1494 | Submission Open
Keywords: kidney disease; focal segmental glomerulosclerosis; genetic kidney disease; minimal change disease; nephrotic syndrome; podocyte
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
DNA Replication, Damage and Repair in Repeat Instability: Their Role from Bacteria to Genetic Disorders in Humans
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1455 | Submission Open
Keywords: DNA repeat instability; DNA replication; DNA damage; DNA repair; tandem repeats; trinucleotide repeats; repeat expansion diseases; microsatellite instability; replication slippage; phenotypic variability; bacteria; genetic disorders
(This special issue belongs to the Section Molecular Genetics and Genomics)
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