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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathogenesis and Novel Therapeutic Approaches for Sarcomas
edited by Francisco Giner
submission deadline 20 May 2026 | 4 articles | Viewed by 10556 | Submission Open
Keywords: soft tissue tumors; bone tumors; molecular biology; target therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Mesenchymal Stem Cells in Organ Repair and Tissue Regeneration
edited by
submission deadline 20 May 2026 | 6 articles | Viewed by 10389 | Submission Open
Keywords: stem cells; differentiation; cell therapy; tissue regeneration; cell mechanisms; regenerative medicine; immunomodulation
(This special issue belongs to the Section Molecular Biology)
Molecular Insights in Antivirals and Vaccines submission deadline 20 May 2026 | 2 articles | Viewed by 9856 | Submission Open
Keywords: new vaccine platforms; cell cultures; plant molecular farming; vaccines and VLPs; nanoparticle vaccines; emerging viral diseases; novel therapeutics; biologics; antibodies; receptor modulators; plant-based compounds with antiviral activity; medicinal plant-derived products; bioactive proteins from plants
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms and Therapies of Colorectal Cancer: 4th Edition submission deadline 20 May 2026 | 7 articles | Viewed by 9799 | Submission Open
Keywords: transforming growth factor beta (TGF-β ) signaling; genetic alterations; molecular targeted therapy precision medicine
(This special issue belongs to the Section Molecular Oncology)
New Cardiovascular Risk Factors: 2nd Edition
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 9301 | Submission Open
Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation
(This special issue belongs to the Section Molecular Biology)
Plant-Derived Bioactives: Antioxidant Mechanisms and Preventive Health Strategies
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 9294 | Submission Open
Keywords: antioxidant; plant-derived bioactive compounds; flavonoids; oxidative stress; mechanisms of action
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Impact of Mitochondria on Human Disease and Health
edited by
submission deadline 20 May 2026 | 5 articles | Viewed by 8619 | Submission Open
Keywords: mitochondrial dysfunction; mitochondrial bioenergetics; mitochondrial dynamics; mitophagy; oxidative stress; mitochondrial DNA (mtDNA) mutations; neurodegenerative diseases; cardiovascular diseases; metabolic disorders; aging and mitochondria; cancer
(This special issue belongs to the Section Biochemistry)
Cutting-Edge Methods for Exploiting Bioactive Compounds in Biomasses: From the Plant Matrix to Molecular Function
edited by Chiara Magni
submission deadline 20 May 2026 | 5 articles | Viewed by 8578 | Submission Open
Keywords: plant matrix; agri-food biomasses; biochemistry; bioactive compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Fish Immunology, 5th Edition submission deadline 20 May 2026 | 4 articles | Viewed by 8033 | Submission Open
Keywords: fish immunology; innate immunity; acquired immunity; leucocytes; disease; immunostimulants; immunodepression; inflammation
(This special issue belongs to the Section Molecular Immunology)
Amyotrophic Lateral Sclerosis (ALS): Pathogenesis and Treatments submission deadline 20 May 2026 | 2 articles | Viewed by 7719 | Submission Open
Keywords: amyotrophic lateral sclerosis; therapeutic applications; extracellular-vesicles; gene variants; RNA metabolism; mitochondrial dysfunction; oxidative stress; neuroinflammation; protein misfolding; muscle impariment
(This special issue belongs to the Section Molecular Neurobiology)
Tumor Microenvironment and Cancer Progression: Molecular Insights for Targeted Therapy
edited by
submission deadline 20 May 2026 | 5 articles | Viewed by 7614 | Submission Open
Keywords: tumor microenvironment; immune response modulation; signaling pathways; extracellular matrix components; tumor evolution
(This special issue belongs to the Section Molecular Oncology)
Macrophages and Inflammation
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 7463 | Submission Open
Keywords: innate immunity; transcriptional programs; epigenetics; immunometabolism; receptors; scavenging; cytokines; ROS
(This special issue belongs to the Section Molecular Immunology)
Antimicrobial and Antiviral Peptides: 2nd Edition
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 7434 | Submission Open
Keywords: antimicrobial peptides; antiviral peptides; peptide mining; molecular mechanism of biological activity; structure– activity relationship; molecular targets; in silico design; in vivo models; peptide delivery strategies; biomedical applications
(This special issue belongs to the Section Biochemistry)
Effects of Stressors During Pregnancy and Breastfeeding on the Child: Molecular Perspectives submission deadline 20 May 2026 | 1 articles | Viewed by 7359 | Submission Open
Keywords: xenobiotics; drugs; gestation; breastfeeding; fetus; placenta; child’ s development; teratogenicity; central nervous system
(This special issue belongs to the Section Molecular Biology)
Bioactive Compound Delivery Systems and Microbiome Interactions submission deadline 20 May 2026 | 2 articles | Viewed by 7313 | Submission Open
Keywords: bioactive compounds; delivery systems; gut microbiome; personalized nutrition; bioavailability; encapsulation technologies; microbiome– bioactive interactions; targeted delivery; precision nutrition; synergistic interactions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms and Treatment of Migraine
edited by Noboru Imai
submission deadline 20 May 2026 | 1 articles | Viewed by 7303 | Submission Open
Keywords: migraine; nitric oxide synthase (NOS); neuropeptides; calcitonin gene-related peptide (CGRP); pituitary adenylate cyclase activating polypeptide (PACAP); molecular pathways; therapeutic targets; neurovascular condition
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioprinting: Progress and Challenges
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 7008 | Submission Open
Keywords: advances in 3D bioprinting technologies; biomaterials for bioprinting; bioprinting applications in tissue engineering and regenerative medicine; cellular and molecular interactions in bioprinted constructs; bio-printed organ and tissue models for disease research
(This special issue belongs to the Section Materials Science)
Molecular Ecology, Physiology and Biochemistry of Insects, 5th Edition
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 6893 | Submission Open
Keywords: insect development and reproduction; molecular endocrinology/neuropeptides; insect immunity; photoperiodism; cold hardiness; global climate change; insect aging; insect– plant interactions; molecular interactions of insects with microorganisms; chemical communication; biochemistry of insect venoms; insect genomics and proteomics; genetic engineering; molecular; volution/population genetics; insect biotechnology
(This special issue belongs to the Section Molecular Immunology)
Advances in G Protein-Coupled Receptor Signaling
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 6853 | Submission Open
Keywords: G protein-coupled receptors (GPCRs)G蛋白偶联受体; seven transmembrane domain (7TM) receptors七跨膜结构域受体; metabotropic receptors代谢型受体; membrane receptors膜受体; GPCRs signalingGPCR信号; GPCRs signaling pathwaysGPCR信号通路; anti-inflammatory effects抗炎作用; inflammatory diseases炎性疾病; metabolic diseases代谢疾病; metabolic effects代谢效应; anti-inflammatory treatment抗炎治疗
(This special issue belongs to the Section Molecular Immunology)
The Role of Natural Compounds in Cancer and Inflammation, 2nd Edition
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 6238 | Submission Open
Keywords: natural compounds; oxidative stress; anti-cancer; anti-inflammatory; natural product synthesis; biological activities
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Vascular Protection by Means of Nutraceuticals
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 6094 | Submission Open
Keywords: cardiovascular disease; drugs; nutrients
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Advances in Opioid Research
edited by Matthew E. Layton
submission deadline 20 May 2026 | 5 articles | Viewed by 6075 | Submission Open
Keywords: methadone; buprenorphine; hyperbaric oxygen; complementary/alternative/integrative treatments; patient-centered outcomes
(This special issue belongs to the Section Molecular Pharmacology)
Exploring Cannabinoids: Molecular Mechanisms and Potential Therapeutic Applications
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 6063 | Submission Open
Keywords: cannabinoids; endocannabinoid system; δ 9-tetrahydrocannabinol (THC); cannabidiol (CBD); inflammation; chronic pain; neurodegenerative disorders; epilepsy; psychosis; cancer-related symptoms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Periodontal Disease: From Molecular Pathogenesis to Precision Diagnostics and Innovative Therapeutics
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 6016 | Submission Open
Keywords: periodontitis; gingivitis; oral microbiome; host– pathogen interactions; periodontal immunology; systemic inflammation; salivary diagnostics; periodontal regeneration; precision dentistry; oral-systemic connections; inflammatory biomarkers; antimicrobial peptides; peri-implantitis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Technical Developments and Recent Applications of Cellular Molecular Imaging
edited by Hanae Sato
submission deadline 20 May 2026 | 3 articles | Viewed by 5789 | Submission Open
Keywords: fluorescence imaging; optogenetics; single-molecule imaging; cellular dynamics; real-time imaging; structural and functional imaging; multimodal imaging
(This special issue belongs to the Section Molecular Biology)
Molecular Studies of Monogenic Diseases: Diagnostics, Mechanisms and Therapeutics
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 5735 | Submission Open
Keywords: cell death pathways; DNA sequencing; drug discovery; gene expression; gene mutation; genetic diagnosis; molecular signaling; molecular therapy; monogenic disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Biological and Molecular Targets in Schizophrenia
edited by Jacopo Sapienza
submission deadline 20 May 2026 | 4 articles | Viewed by 5537 | Submission Open
Keywords: schizophrenia; cognition; negative symptoms; synapses; kynurenine pathway; TAAR1; psychedelics; new treatments
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Research in Antioxidant Activity
edited by Demetrios Kouretas and
submission deadline 20 May 2026 | 5 articles | Viewed by 5492 | Submission Open
Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance
(This special issue belongs to the Section Biochemistry)
Molecular Research on Pathogenesis and Treatment of Pregnancy Complications
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 5466 | Submission Open
Keywords: hypertensive disorders of pregnancy; preeclampsia; molecular biology; biomarker; prevention; therapeutics; placenta
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
FTIR Miscrospectroscopy: Opportunities and Challenges
edited by Simona Sabbatini
submission deadline 20 May 2026 | 3 articles | Viewed by 5415 | Submission Open
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Microbiome Connections in Age-Related Diseases
edited by Shalini Jain
submission deadline 20 May 2026 | 2 articles | Viewed by 5405 | Submission Open
Keywords: microbiome; aging; age-related diseases; Alzheimer’ s; dementia
(This special issue belongs to the Section Molecular Microbiology)
Extraction, Identification and Quantification of Bioactive Molecules
edited by and Rosario Mare
submission deadline 20 May 2026 | 2 articles | Viewed by 5302 | Submission Open
Keywords: extracts; botanicals; nutraceuticals; bioactive molecules; spectrometry; spectrophotometer; chromatography; western blotting; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
The Function of Glial Cells in the Nervous System: 2nd Edition
edited by Krista Minéia Wartchow
submission deadline 20 May 2026 | 3 articles | Viewed by 5138 | Submission Open
Keywords: glial cells; glial– neuronal interaction; glial biomarkers; neurodegenerative diseases; therapeutic approaches
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Applications of Technologies and Techniques for the Extraction of Simple Molecules and Compounds
edited by
submission deadline 20 May 2026 | 5 articles | Viewed by 5097 | Submission Open
Keywords: sample preparation; natural product extraction; purification; pollutant extraction; nutraceutical extraction; extraction of environmental indicators; magnetic extraction; green analytical chemistry; liquid– liquid (micro)extraction; cloud point (micro)extraction; solid phase (micro)extraction; pressurized liquid extraction; ultrasound-assisted extraction; microwave-assisted extraction; deep eutectic solvents; supercritical fluid extraction; molecularly imprinted polymers; QuEChERS (quick; easy; cheap; effective; rugged and safe)
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Host Responses to Virus Infection
edited by Hideki Hayashi and Yoshinao Kubo
submission deadline 20 May 2026 | 3 articles | Viewed by 5084 | Submission Open
Keywords: viral infection; host reactions; interferon alpha and beta; interferon gamma; cytokines; vaccine; cytokine storm
(This special issue belongs to the Section Molecular Microbiology)
New Anti-cancer Agents: Design, Synthesis and Applications submission deadline 20 May 2026 | 2 articles | Viewed by 4978 | Submission Open
Keywords: anti-cancer drugs; cancer drug development; cancer therapy; rational drug design; structure– activity relationship; cancer therapeutics; cytotoxicity; apoptosis; anti-tumor activity
(This special issue belongs to the Section Molecular Pharmacology)
Targeted Therapies and Molecular Methods in Cancer, 3rd Edition
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 4933 | Submission Open
Keywords: immunotherapy; radiotherapy; methods using facilitated drug delivery such as electroporation; sonoporation; and magnetic fields; nanotechnology and nanocarriers; gene electrotherapy; intelligent predicting methods with AI
(This special issue belongs to the Section Molecular Oncology)
Bile Acids and Bile Acid Modifications in Health and Disease submission deadline 20 May 2026 | 3 articles | Viewed by 4829 | Submission Open
Keywords: bile acids; bile acid modifications; bile acid signaling; bile acid metabolism; metabolic disorders
(This special issue belongs to the Section Molecular Microbiology)
Diagnosis and Treatment of Osteoporosis
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 4751 | Submission Open
Keywords: osteoporosis; diagnosis; dual X-rays absorptiometry; DXA; bone turnover markers; secondary osteoporosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Cellular Therapeutics for Respiratory Diseases
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 4492 | Submission Open
Keywords: lung diseases; cystic fibrosis; chronic obstructive pulmonary disease; asthma; drug delivery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Male Reproductive Physiology, Pathophysiology, and Contraception
edited by Gustavo G. Blanco
submission deadline 20 May 2026 | 2 articles | Viewed by 4386 | Submission Open
Keywords: spermatogenesis; spermiogenesis; testis; epididymis; sperm function; sperm motility; sperm capacitation; acrosome reaction; male reproduction; male fertility; male infertility; male contraception
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurological Diseases: From Physiology to Therapy submission deadline 20 May 2026 | 2 articles | Viewed by 4317 | Submission Open
Keywords: neurophysiology; genetics; Alzheimer’ s disease; neurological diseases; neurodegenerative diseases
(This special issue belongs to the Section Molecular Neurobiology)
Advancing Cancer Research: Molecular Insights, Diagnostic Innovations and Therapeutic Targets
edited by Jue Wang
submission deadline 20 May 2026 | 2 articles | Viewed by 4288 | Submission Open
Keywords: cancer; carcinogenesis; molecular pathology; signaling transduction; diagnosis; treatment; prognosis; pathogenesis; precision oncology; biomarker discovery; genomic profiling
(This special issue belongs to the Section Molecular Oncology)
Glioblastoma: Molecular Pathogenesis and Treatment submission deadline 20 May 2026 | 1 articles | Viewed by 4257 | Submission Open
Keywords: glioblastoma; molecular therapy; pathogenesis; immunotherapy; brain tumor
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbiome and Metabolome in the Gastrointestinal Tract, 3rd Edition submission deadline 20 May 2026 | 1 articles | Viewed by 4141 | Submission Open
Keywords: microbiome; dysbiosis; microbiology; immunity; cytokine/chemokine networks; microbiota axes pathways; toxic substances; autoimmunity
(This special issue belongs to the Section Molecular Biology)
New Insights in Artificial Intelligence for Drug Design and Target Discovery
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 4065 | Submission Open
Keywords: pre-trained language models; generative models; drug prediction; binding site prediction; peptides; multi-omics; deep learning; QSAR modeling; molecular dynamics (MD) simulations
(This special issue belongs to the Section Molecular Pharmacology)
Ceramides and Ceramide Kinase
edited by Antonio Gomez-Muñoz
submission deadline 20 May 2026 | 3 articles | Viewed by 4023 | Submission Open
Keywords: cancer; cell survival; ceramides; ceramide 1-phosphate; inflammation
(This special issue belongs to the Section Biochemistry)
New Insights into Chemotherapeutic Agents in Cancer Treatment
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 3988 | Submission Open
Keywords: chemotherapy; molecular mechanisms; signal transduction; apoptosis; drug resistance; biomarkers; DNA damage; targeted therapy; cancer pathways; nanoparticles; nanomedicine; epigenetics
(This special issue belongs to the Section Molecular Pharmacology)
Liposomes: Molecular Marvels in Drug Delivery
edited by and Juyang Huang
submission deadline 20 May 2026 | 1 articles | Viewed by 3928 | Submission Open
Keywords: liposomal drug; targeted delivery; controlled release; hydrogen bonding; long-term stability; archaeosomes; cytotoxicity; lyophilized liposomal drugs
(This special issue belongs to the Section Molecular Biophysics)
The Role of Iodinated Compounds and Molecular Iodine in Human Disease
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 3752 | Submission Open
Keywords: iodine; iodinated compounds; oxidized iodine; oxidized iodine supplement
(This special issue belongs to the Section Biochemistry)
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