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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanism Discovery of the Bioactive Phytochemicals Against Different Diseases Based on Network Pharmacology and Molecular Docking, 2nd Edition

edited by

Baojun Xu

submission deadline 15 Nov 2025 | 6 articles | Viewed by 10874 | Submission Open

Keywords: molecular mechanism; phytochemicals; network pharmacology; molecular docking; diseases; curing targets; signaling pathway; biological processes

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cellular and Molecular Progression of Cardiovascular Diseases

edited by

Andrea Borghini

Antonio Rizza

and

Alessandro Tonacci

submission deadline 20 Nov 2025 | 10 articles | Viewed by 30962 | Submission Open

Keywords: cardiovascular diseases; multi-omics data; biomarkers; molecular level; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Lupus Erythematosus and Lupus Nephritis: Pathogenesis, Biomarkers and Treatments

edited by

Chi Chiu Mok

submission deadline 20 Nov 2025 | 9 articles | Viewed by 30936 | Submission Open

Keywords: lupus erythematosus; lupus nephritis; SLE; LN; organ damage; pathogenesis; biomarkers; genomic; transcriptomic; metabolomic; treatments; therapeutic

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Regenerative Medicine: Biomaterials and Stem Cell Research

edited by Silvia María Díaz-Prado

submission deadline 20 Nov 2025 | 8 articles | Viewed by 28888 | Submission Open

Keywords: regenerative medicine; stem cell; biomaterial; bioprinting; tissue engineering; tissue and organ transplant; organ scarcity

(This special issue belongs to the Section Materials Science)

Advances in the Molecular Biological Effects of Magnetic Fields

edited by

Viacheslav V. Krylov

submission deadline 20 Nov 2025 | 8 articles | Viewed by 28159 | Submission Open

Keywords: magnetoreception magnetoperception alternating magnetic field static magnetic field hypomagnetic field cryptochrome radical-pair mechanism zebrafish Aquatic Species

(This special issue belongs to the Section Molecular Biology)

Drug Treatment for Bacterial Infections

edited by Janusz Madaj

submission deadline 20 Nov 2025 | 12 articles | Viewed by 25259 | Submission Open

Keywords: bacterial infection; antibiotic-resistant bacteria; new agents in the treatment of bacterial infections; optimization of the use of already registered drugs; single antibacterial agents; combined antibacterial agents; new drug forms

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanism of Circadian Rhythm

edited by Rosângela Vieira de Andrade

submission deadline 20 Nov 2025 | 2 articles | Viewed by 23009 | Submission Open

Keywords: circadian cycle; exercise; aging; clock genes; health

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Pain and Analgesia

edited by

Dong-Ho Youn

and Hee Young Kim

submission deadline 20 Nov 2025 | 3 articles | Viewed by 20503 | Submission Open

Keywords: pain; analgesia; sensory transmission and integration; molecular pathways; pain genes; drug targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Lipid Signaling Molecules

edited by Roberta Ottria

submission deadline 20 Nov 2025 | 4 articles | Viewed by 19626 | Submission Open

Keywords: endocannabinoid hydrolytic enzyme inhibitors; endocannabinoids; oxylipins; eicosanoids; lipid signaling (fatty acid derivatives); protectins; maresins; and resolvins

(This special issue belongs to the Section Molecular Biology)

Inflammatory Bowel Disease: Molecular Advances in Pathogenesis and Therapies

edited by

Rafał Filip

submission deadline 20 Nov 2025 | 14 articles | Viewed by 19203 | Submission Open

Keywords: Crohn’ s disease; inflammatory bowel disease; immunologic and molecular mechanisms; therapies for IBD; ulcerative colitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Understanding the Mechanisms of Mitochondrial Stress and Its Association with Human Diseases

edited by

Jaeseok Han

submission deadline 20 Nov 2025 | 6 articles | Viewed by 18554 | Submission Open

Keywords: mitochondrial stress; mitochondrial quality control; mitophagy; mitochondrial unfolded protein response; mitochondrial fission and fusion; mitochondria-related diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Plant Metabolite Research

edited by

Lingqiang Wang

submission deadline 20 Nov 2025 | 8 articles | Viewed by 18099 | Submission Open

Keywords: metabolomics; regulatory networks; metabolic engineering; plant secondary metabolic defense; phytochemicals; antioxidant properties; mass spectrometry imaging; biotechnological applications; plant biochemistry

(This special issue belongs to the Section Molecular Plant Sciences)

Drosophila: A Versatile Model in Biology and Medicine—2nd Edition

edited by

Maria Grazia Giansanti

and

Roberto Piergentili

submission deadline 20 Nov 2025 | 10 articles | Viewed by 16118 | Submission Open

Keywords: model organism; human disease; inherited disease; cancer; neurodegeneration; rare disease; genetics

(This special issue belongs to the Section Molecular Biology)

Female Infertility and Fertility

edited by

Antonio Simone Laganà

and

Simone Garzon

submission deadline 20 Nov 2025 | 4 articles | Viewed by 15865 | Submission Open

Keywords: infertility; embryo; implantation; placenta; endometrium; gynecological endocrinology; assisted reproduction technology; ovaries; inflammation; endometriosis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Diet and Oxidative Stress

edited by

Matteo Becatti

submission deadline 20 Nov 2025 | 3 articles | Viewed by 15443 | Submission Open

Keywords: diet; antioxidants; personalized medicine; oxidative stress; health and disease

(This special issue belongs to the Section Biochemistry)

Exploring Abiotic Stress in Plants: Mechanisms, Adaptations, and Mitigation Strategies

edited by

Tarek Alshaal

submission deadline 20 Nov 2025 | 9 articles | Viewed by 14702 | Submission Open

Keywords: abiotic stress; plant physiology; stress tolerance; crop resilience; molecular mechanisms; biotechnological interventions

(This special issue belongs to the Section Molecular Plant Sciences)

Omics Science and Research in Human Health and Disease

edited by Elisa De Paolis

submission deadline 20 Nov 2025 | 7 articles | Viewed by 14608 | Submission Open

Keywords: genomics; transcriptomics; proteomics; metabolomics; single-cell analysis; spatial transcriptomics; bioinformatics; multi-omics

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Reproductive Biology and Related Diseases

edited by

Alejandro Vicente-Carrillo

submission deadline 20 Nov 2025 | 6 articles | Viewed by 14469 | Submission Open

Keywords: spermatozoa; oocyte; molecular reproduction; infertility

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Inflammatory Airway Diseases: Diagnosis, Pathology, Molecular Mechanisms and Treatment Options

edited by

Stefanie Krick

submission deadline 20 Nov 2025 | 6 articles | Viewed by 14222 | Submission Open

Keywords: inflammatory airway diseases; asthma; COPD; anti-inflammatory

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research in Prebiotics, Probiotics and Postbiotics: 2nd Edition

edited by

Julio Villena

and Haruki Kitazawa

submission deadline 20 Nov 2025 | 6 articles | Viewed by 13872 | Submission Open

Keywords: probiotics; prebiotics; postbiotics; symbiotics; immunobiotics; functional foods; health improvement; mucosal immunology; microbiota

(This special issue belongs to the Section Molecular Microbiology)

Drug Design and Development for Neurological Diseases

edited by

Alicja Nowaczyk

and

Grzegorz Grześk

submission deadline 20 Nov 2025 | 6 articles | Viewed by 13834 | Submission Open

Keywords: neurological disorders and their therapies; molecular modeling; synthesis and structural analysis; neurotransmitters ligands; mechanism of action; drug repurposing

(This special issue belongs to the Section Molecular Pharmacology)

Medicinal Plants and Natural Compounds in Health and Disease: Progresses, Challenges, Opportunities, 2nd Edition

edited by

Adelina Vlad

and

Marilena Gilca

submission deadline 20 Nov 2025 | 2 articles | Viewed by 13444 | Submission Open

Keywords: medicinal plants; phytochemicals; vitamins; oxidative stress; gene expression; protein expression; cellular signaling; ethnopharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Physiology and Molecular Medicine of Molecular Hydrogen

edited by

Tyler W. LeBaron

and John Nagi Kheir

submission deadline 20 Nov 2025 | 2 articles | Viewed by 13187 | Submission Open

Keywords: molecular hydrogen; reactive oxygen species; nitric oxide; inflammation; cardiovascular disease

(This special issue belongs to the Section Molecular Biology)

Coronavirus Disease (COVID-19): Pathophysiology (6th Edition)

edited by

Malgorzata Kloc

and

Jacek Z. Kubiak

submission deadline 20 Nov 2025 | 4 articles | Viewed by 12351 | Submission Open

Keywords: SARS-CoV-2; coronavirus; pandemic; viral diseases; pediatrics; inflammation; immune cells; macrophages; pneumonia; vaccines; cytokines; cytokine storm; PIMS; immunity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Skeletal Muscle Function and Metabolism: Molecular Mechanisms and Treatment—2nd Edition

edited by

Andrea Telek

submission deadline 20 Nov 2025 | 5 articles | Viewed by 12273 | Submission Open

Keywords: skeletal muscle; metabolism; mitochondria; epigenetics; exercise; signalization

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Splice-Switching Antisense Oligonucleotides: 30 Years After Advocating Exon-Skipping Therapy for Duchenne Muscular Dystrophy

edited by

Masafumi Matsuo

submission deadline 20 Nov 2025 | 3 articles | Viewed by 12109 | Submission Open

Keywords: antisense oligonucleotides; modified nucleic acid; splicing; splicing switch; exon skipping; pseudoexon; N-of-1; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cardiovascular Disease and Diabetes: A New Challenge in Treatment and Management

edited by Graziano Riccioni

submission deadline 20 Nov 2025 | 4 articles | Viewed by 12087 | Submission Open

Keywords: hypertension; atherosclerosis; congestive heart failure; diabetes mellitus; therapy; hypercholesterolemia; coronary artery disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Development and Hormonal Signaling

edited by

Naoufal Lakhssassi

submission deadline 20 Nov 2025 | 6 articles | Viewed by 11936 | Submission Open

Keywords: plant growth; reproductive growth; phytohormones; signal transduction; transcription factors; root development; shoot development; floral development; seed development; environmental interactions; regulatory networks; apical dominance

(This special issue belongs to the Section Molecular Plant Sciences)

Microbial Infections and Novel Biological Molecules for Treatment

edited by Matthew Cheesman

submission deadline 20 Nov 2025 | 9 articles | Viewed by 11774 | Submission Open

Keywords: microbial infections; infectious diseases; new antibiotics; antimicrobial resistance (AMR); antimicrobial drugs; active substance; bacterial; virus

(This special issue belongs to the Section Molecular Microbiology)

Cardiovascular Diseases: From Pathology to Therapeutics

edited by

Woongbi Jang

submission deadline 20 Nov 2025 | 4 articles | Viewed by 11565 | Submission Open

Keywords: cardiovascular diseases; pathologies; cardiac progenitor cells; molecular pathways; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Gastrointestinal Tract Oncology: Pathology, Diagnostics and Therapy

edited by

Karolina Orywal

and Mariusz Gryko

submission deadline 20 Nov 2025 | 7 articles | Viewed by 11248 | Submission Open

Keywords: gastrointestinal cancer; esophageal cancer; gastric (stomach) cancer; colorectal cancer; liver cancer; pancreatic cancer; gallbladder and biliary tract cancer; genetic alterations; molecular subtyping; tumor microenvironment; innovative therapies; targeted therapies; tumor biomarkers

(This special issue belongs to the Section Molecular Oncology)

Signaling and Stress Adaptation in Plants

edited by

Kangdi Hu

and

Yi Han

submission deadline 20 Nov 2025 | 8 articles | Viewed by 11245 | Submission Open

Keywords: plants; environmental stress; stress signaling; reactive oxygen/nitrogen species; calcium; protein kinases; stress resistance; adaptive mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Antimicrobial Nanoparticles

edited by

Tarek Ali Ahmed Ibrahim Alshaal

submission deadline 20 Nov 2025 | 1 articles | Viewed by 10556 | Submission Open

Keywords: nanotechnology; antimicrobial agents; nanoparticle synthesis; biomedical applications; targeted delivery; mechanisms of action

(This special issue belongs to the Section Molecular Nanoscience)

Cheminformatics in Drug Discovery and Green Synthesis

edited by

Ana Amić

submission deadline 20 Nov 2025 | 6 articles | Viewed by 10433 | Submission Open

Keywords: cheminformatics; drug discovery; databases; in silico methods; green chemistry

(This special issue belongs to the Section Molecular Informatics)

Advanced Research on Chemokines and Chemokine Receptors

edited by

Bouchra Edderkaoui

submission deadline 20 Nov 2025 | 4 articles | Viewed by 10275 | Submission Open

Keywords: chemokines; chemokine receptors; chronic diseases; angiogenesis; fracture; regeneration; chemokine function; expression

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights in Reproductive Immunology and Placental Pathology, 2nd Edition

edited by

Dariusz Szukiewicz

submission deadline 20 Nov 2025 | 5 articles | Viewed by 10261 | Submission Open

Keywords: gamete immunology; in vitro fertilization; infertility; immunocontraception; implantation; placentation; immunotolerance; reproductive immunology; inflammation; cytokine network; placenta-derived stem cells; placental development; placental insufficiency; endometriosis; immunopathology of pregnancy; sex hormones

(This special issue belongs to the Section Molecular Immunology)

Bacteriophage—Molecular Studies (6th Edition)

edited by

Alicja Wegrzyn

submission deadline 20 Nov 2025 | 4 articles | Viewed by 10219 | Submission Open

Keywords: bacteriophage biodiversity; regulation of bacteriophage development; molecular processes in bacteriophages; bacteriophage-based biotechnology; phage therapy

(This special issue belongs to the Section Biochemistry)

Sjogren's Disease: Multidimensional Perspectives on Pathogenesis, Clinical Manifestations, and Therapeutic Advancements

edited by

Xiang Lin

submission deadline 20 Nov 2025 | 7 articles | Viewed by 10027 | Submission Open

Keywords: Sjö gren's disease; diagnosis; therapeutics; bioinformatics; pre-clinical; cytokine; lymphocytes; autoantibodies; exocrine glands

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Abnormal Organelles and Protein Expression in Acute and Chronic Neurodegeneration

edited by

Francesco Fornai

submission deadline 20 Nov 2025 | 3 articles | Viewed by 9684 | Submission Open

Keywords: brain ischemia; epileptic damage; basal ganglia pathology; catecholamine cell damage; excitotoxicity; autophagy; dopamine system norepinephrine system; protein unfolding; protein misfolding; cholinergic system

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and New Markers of Cancer

edited by

Antonio D’Amati

submission deadline 20 Nov 2025 | 5 articles | Viewed by 9577 | Submission Open

Keywords: molecular pathology; molecular mechanisms; immunotherapy; cancer; oncology; pathology; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Astrocyte-Endothelial Interactions at the Blood-Brain Barrier, 2nd Edition

edited by

Dariusz Szukiewicz

submission deadline 20 Nov 2025 | 3 articles | Viewed by 9320 | Submission Open

Keywords: blood– brain barrier (BBB); astrocyte– endothelial interactions; cytokine signaling; astrocytic modulation; brain microvascular endothelial cells; chemokine receptors; BBB permeability; BBB dysfunction; BBB pharmacokinetics; cerebrovascular disease; oxidative stress; BBB models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Emerging Therapies in Neurovascular Disease

edited by Leonidas D. Panos

submission deadline 20 Nov 2025 | 3 articles | Viewed by 9297 | Submission Open

Keywords: neurovascular diseases; blood– brain barrier; endothelial dysfunction; cellular signaling; gene therapy

(This special issue belongs to the Section Molecular Neurobiology)

Involvement of Neuroinflammatory Processes in Psychiatric Conditions

edited by

Cristina Núñez

submission deadline 20 Nov 2025 | 4 articles | Viewed by 9253 | Submission Open

Keywords: neuroinflammation; glia; chemokine; cytokine; psychiatry disorder; motivation; learning; behavior; mental illness; psychopharmacology

(This special issue belongs to the Section Molecular Neurobiology)

New Insights into Mitochondria in Health and Diseases

edited by

Josephine S. Modica-Napolitano

submission deadline 20 Nov 2025 | 5 articles | Viewed by 9250 | Submission Open

Keywords: mitochondrial bioenergetics; reactive oxygen species; apoptosis; aging; immune function; mtDNA mutations; mitochondrial dysfunction; mitochondria-targeted therapies

(This special issue belongs to the Section Biochemistry)

Molecular Insights in Antivirals and Vaccines

edited by

Gergana Zahmanova

Ivan Minkov

and

Yoana Dimitrova Kiselova-Kaneva

submission deadline 20 Nov 2025 | 2 articles | Viewed by 9104 | Submission Open

Keywords: new vaccine platforms; cell cultures; plant molecular farming; vaccines and VLPs; nanoparticle vaccines; emerging viral diseases; novel therapeutics; biologics; antibodies; receptor modulators; plant-based compounds with antiviral activity; medicinal plant-derived products; bioactive proteins from plants

(This special issue belongs to the Section Molecular Microbiology)

Exploring the Molecular Mechanisms of Chronic Kidney Disease

edited by

Juan Miguel Diaz-Tocados

submission deadline 20 Nov 2025 | 5 articles | Viewed by 9018 | Submission Open

Keywords: chronic kidney disease; hereditary renal disease; renal hypertension; diabetic nephropathy; secondary hyperparathyroidism; cardiovascular disease; renal osteodystrophy; peritoneal dialysis; hemodialysis; anemia; metabolic acidosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antioxidant and Antibacterial Properties of Phytochemicals

edited by

Dalia Urbonaviciene

and Vytaute Starkute

submission deadline 20 Nov 2025 | 5 articles | Viewed by 8204 | Submission Open

Keywords: phytochemicals; natural preservatives; antioxidants; antibacterial properties; food; cosmetics; pharmaceuticals; animal feed

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Research of Natural Products from Microalgae and Cyanobacteria

edited by

Biswajita Pradhan

submission deadline 20 Nov 2025 | 4 articles | Viewed by 8194 | Submission Open

Keywords: marine and fresh water microalgal and cyanobacterial bioactive compounds; microalgal and cyanobacterial carotenoids; vitamins; phenolics; and phycobiliproteins; microalgal and cyanobacterial alkaloids; microalgal and cyanobacterial polysaccharides; microalgal and cyanobacterial peptides; microalgal and cyanobacterial polyphenols; microalgal and cyanobacterial antioxidants; microalgal and cyanobacterial pharmaceuticals; microalgal and cyanobacterial nutraceuticals; microalgal and cyanobacterial anti-inflammatory compounds; microalgal and cyanobacterial antimicrobial compounds; microalgal and cyanobacterial anticancer compounds; microalgal and cyanobacterial neuroprotective compounds; microalgal and cyanobacterial antiviral compounds; microalgal and cyanobacterial-derived anti-aging compounds; microalgal and cyanobacterial extracts

(This special issue belongs to the Section Biochemistry)

The Molecular Basis of Plant–Microbe Interactions

edited by

Stephan Pollmann

Luis Morales-Quintana

and

Patricio Ramos

submission deadline 20 Nov 2025 | 3 articles | Viewed by 8126 | Submission Open

Keywords: plant immune and defense responses; microbe and microbiome function; microbial biodiversity; abiotic and biotic stress mitigation; gene regulatory mechanisms; plant hormones in plant– microbe interactions; molecular mechanisms of plant growth and microbe interactions; chemical communication in plant– microbe interactions; microbe effects on fruit quality; OMICs approaches (metagenomics; metatranscriptomics; epigenomics; transcriptomics; metabolomics); bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Progress in New Agents to Treat Breast Cancer

edited by Eileen Brantley

submission deadline 20 Nov 2025 | 4 articles | Viewed by 8095 | Submission Open

Keywords: breast cancer; chemotherapeutic agents; DNA-alkylating drugs; anthracyclines; antimetabolites; taxanes

(This special issue belongs to the Section Molecular Oncology)

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