ijms-logo

Journal Browser

Journal Browser

Special Issue "Inflammatory Skin Conditions 2019"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 29 November 2019.

Special Issue Editor

Guest Editor
Prof. Dr. Christopher Jackson Website E-Mail
Sutton Arthritis Research Laboratory, Kolling Institute, University of Sydney at Royal North Shore Hospital, Sydney, Australia
Interests: inflammation; chronic wounds; rheumatoid arthritis; skin; activated protein C; matrix metalloproteinases

Special Issue Information

Dear Colleagues,

The skin provides a barrier to protect the body from environmental insults, including pathogens, as well as maintaining temperature, and control evaporation. It comprises the epidermis, composed mainly of keratinocytes and the dermis, housing largely fibroblasts, blood vessels and matrix. Breaches of this barrier are common events, however, the inability to restore this barrier function can result in common health problems which have high morbidity and in some cases mortality. This diverse group of diseases includes acne, rosacea, atopic dermatitis, psoriasis, chronic wounds, blistering diseases and toxic epidermal necrolysis. Although these may be grouped under a single heading of inflammatory skin disorders there are many different molecular pathways involved, including multiple soluble mediators and cellular receptors as well as signalling molecules such as NF-kB, mTOR, MAP kinases and Akt. Understanding these molecular mechanisms are a vital step to providing new and innovative approaches to dampen inflammation and restore the defective barrier to better treat and ultimately cure these recalcitrant conditions.

This Special Issue calls for original research, full reviews, and perspectives that address the progress and current knowledge in the overlapping research topics of inflammatory skin conditions. These include but are not limited to the fields that are mentioned in the keywords.

Prof. Dr. Christopher Jackson
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory skin conditions
  • chronic wounds
  • psoriasis
  • dermatitis
  • epidermis
  • molecular signalling
  • cellular receptors
  • keratinocytes
  • angiogenesis
  • barrier function
  • inflammatory cells
  • immunity

Related Special Issues

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Open AccessReview
Derailed Ceramide Metabolism in Atopic Dermatitis (AD): A Causal Starting Point for a Personalized (Basic) Therapy
Int. J. Mol. Sci. 2019, 20(16), 3967; https://doi.org/10.3390/ijms20163967 - 15 Aug 2019
Abstract
Active rebuilding, stabilizing, and maintaining the lipid barrier of the skin is an encouraging disease management and care concept for dry skin, atopic dermatitis (eczema, neurodermatitis), and psoriasis. For decades, corticosteroids have been the mainstay of topical therapy for atopic dermatitis; however, innovations [...] Read more.
Active rebuilding, stabilizing, and maintaining the lipid barrier of the skin is an encouraging disease management and care concept for dry skin, atopic dermatitis (eczema, neurodermatitis), and psoriasis. For decades, corticosteroids have been the mainstay of topical therapy for atopic dermatitis; however, innovations within the scope of basic therapy are rare. In (extremely) dry, irritated, or inflammatory skin, as well as in lesions, an altered (sphingo)lipid profile is present. Recovery of a balanced (sphingo)lipid profile is a promising target for topical and personalized treatment and prophylaxis. New approaches for adults and small children are still lacking. With an ingenious combination of commonly used active ingredients, it is possible to restore and reinforce the dermal lipid barrier and maintain refractivity. Lysosomes and ceramide de novo synthesis play a key role in attenuation of the dermal lipid barrier. Linoleic acid in combination with amitriptyline in topical medication offers the possibility to relieve patients affected by dry and itchy skin, mild to moderate atopic dermatitis lesions, and eczemas without the commonly occurring serious adverse effects of topical corticosteroids or systemic antibody administration. Full article
(This article belongs to the Special Issue Inflammatory Skin Conditions 2019)
Show Figures

Figure 1

Back to TopTop