Special Issue "GRKs and Arrestins in Human Health and Disease"
Deadline for manuscript submissions: 31 July 2020.
The five non-visual G protein-coupled receptor kinases (GRKs), acting together with the two non-visual arrestins (beta-arrestin-1 and -2), play fundamental roles in the regulation of signaling and function of G protein-coupled receptors (GPCRs). GPCRs are by far the most populous and versatile family of receptors in the human genome, with more than one-third of currently used in clinical practice drugs being ligands for these receptors. GRKs and beta-arrestins regulate GPCR function by modulating receptor-stimulated G protein signaling but also by mediating most of the G protein-independent signaling of GPCRs. Additionally, GRKs and beta-arrestins have a growing number of previously unappreciated cellular effects that are not GPCR-dependent; e.g., GRKs can phosphorylate non-GPCR substrates. Given the extreme importance of the ~350 different non-sensory (i.e., druggable) human GPCRs in the physiology of every organ system of the human body, these two protein families of GPCR regulators (GRKs and beta-arrestins) represent attractive therapeutic targets for drug discovery and development. This Special Issue of the International Journal of Molecular Sciences is focused on studies that explore the functional roles of GRKs and arrestins in human physiology and disease. Novel pharmacological hypotheses and medicinal chemistry endeavors toward novel drug development are particularly encouraged for submission to this Special Issue. Original investigations, review articles, and short communications are all welcome. The following list of subtopics, although by no means exhaustive, is of particular interest:
- signal transduction;
- autonomic signaling;
- cognitive dysfunction/neurodegeneration;
- heart failure;
- cardiac arrhythmias;
- metabolic syndrome/diabetes;
- stem cell biology/physiology;
- Acute Coronary Syndrome;
- inflammation/autoimmune diseases;
- cardiovascular endocrinology (e.g., adrenal gland and neuronal control of the circulation);
- end-organ damage;
- respiratory diseases;
- reproductive (patho)physiology.
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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