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Special Issue "Alpha-Synuclein in Neurological Disorders: From Physiology to Pathology"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 183

Special Issue Editors

Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France
Interests: neurodegenerative diseases; neuronal cell death; protein aggregation; autophagy-lysosome pathway; animal models
Special Issues, Collections and Topics in MDPI journals
Achucarro Basque Center for Neuroscience, Leioa, Spain
Interests: adult cell regeneration (neurogenesis and gliogenesis); neuron/astrocytes interaction; astrocyte biology; iPSc-derived neural cells, Parkinson disease; brain ischemia
Special Issues, Collections and Topics in MDPI journals
Achucarro Basque Center for Neuroscience, Leioa, Spain
Interests: extracellular matrix; microglia; neurodegeneration; Parkinson’s disease; brain ischemia; live imaging; image analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The physiological role of the protein α-synuclein is widely debated. It is expressed constitutively in neurons and found in glia under certain pathological conditions. More recently, the function of α-synuclein in the CNS has been associated with the regulation of exocytotic neurotransmitter release at the synapse. The fibrillary aggregation of α-synuclein and its spread throughout neuroanatomically connected regions are hallmarks of a series of neuropathologies termed synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, pure autonomic failure, and multiple system atrophy. Since the discovery of α-synuclein in Lewy bodies in 1997, a wealth of information about this protein has become available. However, several questions remain unanswered: is α-synuclein aggregation a cause or effect of the pathological process? What determines the transition from the physiological to pathological state of α-synuclein? Is neuronal α-synuclein different from the α-synuclein found in glial cells? Is it worth using α-synuclein in animal models? In this Special Issue, we aim to shed light upon the complex scenario of α-synuclein’s transition from physiology to pathology in synucleinopathies, with a wide view from the clinic to basic experimental knowledge.

Dr. Benjamin Dehay
Dr. Fabio Cavaliere
Dr. Federico N. Soria
Guest Editors

Manuscript Submission Information

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  • neuroinflammation
  • neurodegeneration
  • gliosis
  • synaptic function
  • exocytosis
  • endocytosis

Published Papers

There is no accepted submissions to this special issue at this moment.
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