Special Issue "Physiological and Pathological Roles of ABC Transporters 2.0"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 August 2020.
2. Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3. School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Special Issues and Collections in MDPI journals
This Special Issue is the continuation of our previous special issue " Physiological and Pathological Roles of ABC Transporters".
The human ATP-Binding Cassette (ABC) superfamily of molecules contains members with broad relevance to multiple physiological functions, which are associated with significant distinct disease states when mutated or dysregulated, while at the same time representing, in such situations, promising emerging targets for therapeutic interventions. The overarching goal of this ABC Molecule Thematic Issue is to present (i) a state-of-the-art overview of the structure and function of ABC proteins; (ii) to present examples of ABC-associated genetic disorders that have already been successfully targeted or represent emerging targets for molecular therapeutic intervention; (iii) to review important recent advances in the roles of ABC molecules in stem cell biology and explore how this knowledge can be transformed to clinical applications in novel stem cell-based tissue-regenerative or anti-cancer approaches; and (iv) to present the latest findings on the roles of ABC members as drug resistance mediators and potential targets in pharmacological cancer therapy. While a comprehensive treatment of all the broad and important advances of the ABC field can obviously not be offered in a single thematic issue, we nevertheless strive to present important examples of some particularly dynamic and stimulating aspects of this exciting field.Dr. Markus Frank
Dr. Natasha Frank
Manuscript Submission Information
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- ATP-binding cassette, ABC transporters
- structure, function
- CFTR, ABCA4, ABCB1, ABCB5, ABCG2
- stem cells, cancer stem cells
- tissue regeneration
- cancer therapy
- drug resistance
- cystic fibrosis
- Stargardt’s Disease
- Limbal Stem Cell Deficiency