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We feel that there is a specific unmet need for a summit on the signaling mechanisms that mediate cancer-related function of cytokines either in cancer cells or within the microenvironment or associated with cancer noxias such as DNA damaging agents, infectious disease or aging related processes. The proposed Aegean conference on the cytokine signaling in cancer should fill this gap and bring together outstanding experts in the area and enable exchange the information and ideas important for improving our understanding of cancer etiology and pathogenesis. This should pave roads towards design of novel anti-cancer therapeutic modalities.