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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetics of Host–Pathogen Interactions

edited by

Transito Garcia-Garcia

and Sara Zaldívar López

submission deadline 15 Mar 2026 | Viewed by 284 | Submission Open

Keywords: pathogen virulence factors; infection susceptibility; immune evasion; genomics of infectious diseases; host– pathogen co-evolution; host– pathogen dynamics; microbiome– host interactions; emerging infectious diseases; crispr and gene editing in host– pathogen studies; transcriptomics and gene expression profiling

(This special issue belongs to the Section Molecular Genetics and Genomics)

Epigenetic Dynamics in Cancer and Aging

edited by

Hayan Lee

submission deadline 15 Mar 2026 | Viewed by 181 | Submission Open

Keywords: DNA methylation; histone modification; chromatin 3D modeling; non-coding RNA; long-read sequencing technology; single-cell epigenetics; cancer initiation and development; epigenetic alterations in the aging process; aging-specific epigenetic alterations; cancer-specific epigenetic alterations

(This special issue belongs to the Section Epigenomics)

Genetic Markers in Targeted Therapies: From Biomarker Discovery to Personalized Therapy

edited by

Maciej Wnuk

submission deadline 15 Mar 2026 | Viewed by 154 | Submission Open

Keywords: cancer diagnosis; molecular; cytogenetic biomarkers; genomic instability; cellular senescence; human disease; clinical applications; personalized therapy; theranostics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cancer Epigenetics: From Laboratory Studies and Clinical Trials to Precision Medicine

edited by Rajendra Pangeni

submission deadline 15 Mar 2026 | Viewed by 63 | Submission Open

Keywords: cancer; epigenetics; laboratory studies; tumor biology; precision medicine; clinical trials; therapy resistance; biomarkers; personalized care; therapeutic interventions

(This special issue belongs to the Section Epigenomics)

Epigenetic Landscape of Neurodevelopmental Disorders

edited by Bimal Jana

submission deadline 15 Mar 2026 | Viewed by 63 | Submission Open

Keywords: epigenetics; neurodevelopmental disorders (NDDs); DNA methylation; 3D genome architecture; histone modifications; non-coding RNA; autism spectrum disorder (ASD); Rett syndrome; neurodevelopment; gene-environment interaction; epigenetic biomarkers; single-cell epigenomics; epigenetic therapy

(This special issue belongs to the Section Neurogenomics)

Forensic DNA Profiling: PCR Techniques and Innovations

edited by

António Amorim

and

Laura Mendes Cainé

submission deadline 16 Mar 2026 | Viewed by 306 | Submission Open

Keywords: forensic DNA profiling; PCR-based forensics; DNA analysis; next-generation sequencing; short tandem repeat (STR); Y-STR; single-nucleotide polymorphisms (SNPs); Y-SNP

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

RNA Biology and Diseases

edited by Sharon Moshitch-Moshkovitz

submission deadline 20 Mar 2026 | 1 articles | Viewed by 456 | Submission Open

Keywords: mechanisms of RNA processing; RNA modification and epitranscriptomics; regulatory RNAs; RNA-based therapy (ASOs; targeted modifications); RNA– protein interactions; non-coding RNAs and diseases; post-translational modifications in shaping the epitranscriptome; RNA structures and restructuring mechanisms

(This special issue belongs to the Section RNA)

Genetic Diagnosis and Genomics of Neurological Diseases

edited by

Avi Fellner

and Penina Ponger

submission deadline 20 Mar 2026 | Viewed by 324 | Submission Open

Keywords: neurogenetics; hereditary neurological diseases; genetic diagnosis; genotype– phenotype correlation; next-generation sequencing; precision neurology; clinical genomics; diagnostic yield; genomic technologies; data-driven approaches

(This special issue belongs to the Section Genetic Diagnosis)

The Regulation of mRNA Translation in Health and Disease

edited by Jun Ling

submission deadline 20 Mar 2026 | Viewed by 318 | Submission Open

Keywords: mRNA translation; mRNA biology; transcriptional regulation; cell signaling; cancer therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Mouse Models of Human Disease

edited by Jiale Wang

submission deadline 20 Mar 2026 | Viewed by 270 | Submission Open

Keywords: mouse models; human disease; genetic disorders; genome editing; CRISPR; inflammation; cancer biology; disease mechanisms; preclinical models; translational research

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of Non-Coding RNA in Cancer

edited by Amil M. Shah

submission deadline 20 Mar 2026 | Viewed by 190 | Submission Open

Keywords: non-coding RNA (ncRNA); ncRNA classification; ncRNA biogenesis; ncRNA functions; diagnostic and prognostic biomarkers; targeted therapy; nucleic acid-based therapy; cell regulatory networks; cancer attractor states; computational network models; omics technology (single-cell RNA-seq; spatial transcriptomics; and single-cell multi-omics)

(This special issue belongs to the Section RNA)

Canine Genomics and Disease Research

edited by

Jeffrey Kidd

submission deadline 20 Mar 2026 | Viewed by 154 | Submission Open

Keywords: canine genetics; trait mapping; genome structure and function; population genetics; association studies; canine evolution; canine disease

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics and Reproduction in Pigs

edited by Rui Cai

submission deadline 20 Mar 2026 | Viewed by 131 | Submission Open

Keywords: pig; spermatogenesis; semen preservation; reproductive technology; genomic selection

(This special issue belongs to the Section Animal Genetics and Genomics)

Machine Learning in Cancer and Disease Genomics

edited by

Piero Fariselli

and Giovanni Birolo

submission deadline 25 Mar 2026 | 5 articles | Viewed by 14390 | Submission Open

Keywords: machine learning; cancer genomics; disease genomics; bioinformatics; genomic data analysis; biomarker discovery; multi-omics integration; personalized medicine; computational biology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Epigenetics of Cellular Differentiation

edited by

Theodora Sideri

submission deadline 25 Mar 2026 | Viewed by 698 | Submission Open

Keywords: stem cells; differentiation; gene expression; genetics; histone modifications; DNA methylation

(This special issue belongs to the Section Epigenomics)

Genetics and Genomics of Insects

edited by Hui Ai

submission deadline 25 Mar 2026 | 2 articles | Viewed by 684 | Submission Open

Keywords: insect molecular biology; genomics; molecular systematics; transcriptomics; genetic; genomic; pest management strategies; gene function; insect chemical ecology

(This special issue belongs to the Section Animal Genetics and Genomics)

Utilizing Multi-Omics to Investigate Neurodegenerative Disorders

edited by Muhammad Ali

submission deadline 25 Mar 2026 | Viewed by 395 | Submission Open

Keywords: neurodegeneration; central nervous system; diagnosis; prognosis; biomarkers; predictive modeling; brain; cerebrospinal fluid; plasma; multi-omics

(This special issue belongs to the Section Neurogenomics)

Mitochondrial Genetics: Progress and Challenges

edited by

Konstantin Khrapko

submission deadline 25 Mar 2026 | Viewed by 342 | Submission Open

Keywords: Mitochondria; ; mtDNA; ; mutation; ; selection; ; germline; ; mitchondrial disease; ; inheritance; ; population; ; evolution; ; NUMT

(This special issue belongs to the Section Molecular Genetics and Genomics)

Livestock Germplasm Resources, Genetics, and Breeding

edited by

Enrico D’ Alessandro

and Marco Tolone

submission deadline 25 Mar 2026 | Viewed by 296 | Submission Open

Keywords: animal genetics; genomics; animal production; metagenomics; genome-wide association study (GWAS); product quality; fertility; health; coat color; molecular traceability; biodiversity

(This special issue belongs to the Section Animal Genetics and Genomics)

Reviews in Aquaculture Genetics: Insights and Advances

edited by

Antonio Figueras

Beatriz Novoa

, Magali Rey-Campos and

Amaro Saco

submission deadline 25 Mar 2026 | Viewed by 170 | Submission Open

Keywords: aquaculture genetics; fish genomics; shellfish breeding; quantitative trait loci; marker-assisted selection; genomic selection; transcriptomics; epigenomics; disease resistance; growth traits; aquatic species; genome assembly; population genomics; selective breeding; sustainable aquaculture

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Mechanisms of Obesity

edited by

Thangiah Geetha

submission deadline 25 Mar 2026 | Viewed by 152 | Submission Open

Keywords: obesity; genetic mechanisms; epigenetics; DNA methylation; genome-wide association studies; multi-omics; transcriptomics; foundtional genomics; gene– environment interactions; childhood obesity; energy metabolism; precision medicine; gut microbiota

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The Genetic Lens: A New Era in Ophthalmology

edited by

Stefania Zampatti

and

Emiliano Giardina

submission deadline 25 Mar 2026 | Viewed by 114 | Submission Open

Keywords: ophthalmology; genomics; artificial intelligence; inherited retinal disease; blindness

(This special issue belongs to the Section Genetic Diagnosis)

Genetic Aspects of Autoimmune Diseases

edited by Cheuk Wun Li

submission deadline 25 Mar 2026 | Viewed by 103 | Submission Open

Keywords: autoimmune diseases; genetics; genetic variants; polygenic; therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Chromatin Modifications and RNA-Based Regulation of Gene Expression

edited by Alonso Javier Pardal

submission deadline 25 Mar 2026 | Viewed by 57 | Submission Open

Keywords: chromatin modifications; RNA; gene expression; transcription; chromatin boundaries; RNA-binding proteins

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics and Genomics of Aging and Longevity, Pathways and Response to Nutrients in Mammals and Simple Model Organisms

edited by

Mario G. Mirisola

submission deadline 30 Mar 2026 | Viewed by 197 | Submission Open

Keywords: nutrigenetics; nutrigenomics; signal transduction

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Application of CRISPR/Cas9 Technology in Insects

edited by

Sanyuan Ma

submission deadline 31 Mar 2026 | Viewed by 130 | Submission Open

Keywords: genome editing; gene targeting; CRISPR/Cas9; insect genetics; pest control; disease vector control; gene drive; off-target effects; delivery systems; ecological impact; transgenic insects; functional genomics

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics of Neuropsychiatric Disorders

edited by Melloni Cook and Kristin Hamre

submission deadline 5 Apr 2026 | 7 articles | Viewed by 7169 | Submission Open

Keywords: major depressive disorder; schizophrenia; post-traumatic stress disorder; addiction; alcohol; drugs; anxiety disorder; stress-related disorders; genes; epigenetics; mRNA; optogenetics; miRNA; causal variant

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genes and Gene Therapies in Chronic Renal Disease

edited by Thomas Kitzler

submission deadline 5 Apr 2026 | 3 articles | Viewed by 4378 | Submission Open

Keywords: chronic renal disease; personalized medicine; exome and genome sequencing; nephrogenetics; genetic kidney disease; small molecules; mRNA therapies; gene editing; gene delivery

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Epigenetic Factors for Autoimmune Diseases

edited by

Ulises De La Cruz-Mosso

submission deadline 5 Apr 2026 | 1 articles | Viewed by 1223 | Submission Open

Keywords: single nucleotide variants; polymorphism; mutations; microRNAs; HLA genes; cytokine gene; DNA methylation; rheumatoid arthritis; systemic lupus erythematosus; exposome

(This special issue belongs to the Section Epigenomics)

Conservation Genetics of Birds

edited by Robert Rutkowski

submission deadline 6 Apr 2026 | Viewed by 139 | Submission Open

Keywords: conservation genetics; birds; aves; endangered species; molecular markers; genetic diversity; genetic distance; isolated populations; non-invasive sampling; genetic monitoring; reintroduction; inbreeding; outbreeding; evolutionary significant units; management unit

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Status and Perspectives of Fisheries Resources

edited by Wei Wang

submission deadline 10 Apr 2026 | 1 articles | Viewed by 475 | Submission Open

Keywords: population genetics; aquaculture breeding and biotechnology; fisheries resource conservation and sustainable utilization; fisheries resource management; genetic technology and methods; climate change and genetic responses

(This special issue belongs to the Section Animal Genetics and Genomics)

Coordinating Regulation of Gene Expression in Cardiovascular Disease

edited by

Nirmal Parajuli

submission deadline 10 Apr 2026 | Viewed by 237 | Submission Open

Keywords: microRNA; oxidative stress; cardiovascular disease; chronic obstructive pulmonary disease (COPD); pulmonary hypertension; gene regulation; inflammation; reactive oxygen species (ROS); molecular biomarkers; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Genomics and Epigenetics of Hearing Loss

edited by Alessandro Castiglione

submission deadline 10 Apr 2026 | Viewed by 205 | Submission Open

Keywords: genetics; hearing loss; inner ear; epigenetics; auditory system

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Progress and Applications of Sequencing Technologies

edited by

Domenico Giosa

and Maria Papale

submission deadline 10 Apr 2026 | Viewed by 194 | Submission Open

Keywords: genomics; transcriptomics; epigenomics; metagenomics; bioinformatics; data analysis

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genetic Insights and Molecular Pathways in Alzheimer's Disease: Unveiling the Complexity of Neurodegeneration

edited by Marta Rusek and

Alessandro Romano

submission deadline 10 Apr 2026 | Viewed by 130 | Submission Open

Keywords: Alzheimer’ s disease; neurodegeneration; amyloid-β pathology; tau pathology; APOE ε 4; APP; PSEN1; PSEN2; GWAS; neuroinflammation; mitochondrial dysfunction; oxidative stress; proteostasis; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics in Canines: From Evolution to Conservation

edited by

Marco Galaverni

and

Romolo Caniglia

submission deadline 15 Apr 2026 | 4 articles | Viewed by 11405 | Submission Open

Keywords: Canis lupus; genetics; genomics; conservation; evolution; adaptation; hybridization

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic and Genomic Advances in Livestock

edited by Karel Vališ

submission deadline 15 Apr 2026 | Viewed by 312 | Submission Open

Keywords: NGS; SNP calling; bioinformatic tools; livestock phenotype; livestock welfare

(This special issue belongs to the Section Animal Genetics and Genomics)

Genes, Genomes, and Systems Biology in Agriculture

edited by Nick Hudson and

Pâmela A. Alexandre

submission deadline 15 Apr 2026 | Viewed by 211 | Submission Open

Keywords: systems biology; modelling; omics technologies; big data; machine learning; genetics; genomics; transcriptomics; microbiome; metabolomics

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genetics in Thyroid Cancer

edited by

Tatjana Bogovic Crncic

and Tomislav Jukić

submission deadline 15 Apr 2026 | Viewed by 210 | Submission Open

Keywords: genetic mutations; thyroid cancer; molecular diagnostics; risk stratification; novel therapies; MAPK/PI3K-AKT signalling; radioiodine-refractory; redifferentiation therapeutic strategies; tumour genomic profiling; targeted therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Non-Coding RNAs in Osteoarthritis: From Epigenetic Regulation to Therapeutic Targets

edited by Ioanna Papathanasiou

submission deadline 15 Apr 2026 | Viewed by 156 | Submission Open

Keywords: osteoarthritis; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; therapeutic strategies

(This special issue belongs to the Section RNA)

From Genes to Systems: Genetic and Epigenetic Control of the Metastatic Cascade

edited by Eric Rahrmann

submission deadline 15 Apr 2026 | Viewed by 133 | Submission Open

Keywords: cancer metastasis; genetic alterations; epigenetic reprogramming; tumor heterogeneity; lineage plasticity; metastatic niche formation; dormancy; circulating tumor cells (CTCs); immune evasion; therapy resistance; tumor microenvironment

(This special issue belongs to the Section Epigenomics)

Genetic and Genomic Analysis of Inflammatory Bowel Disease

edited by Mario Gorenjak and

Gregor Jezernik

submission deadline 15 Apr 2026 | Viewed by 118 | Submission Open

Keywords: inflammatory bowel disease; crohn’ s disease; ulcerative colitis; genomics; transcriptomics; biologicals; small-molecule drugs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Human Reproductive and Prenatal Genetics

edited by Edith Said

submission deadline 15 Apr 2026 | Viewed by 32 | Submission Open

Keywords: reproductive genetics; female infertility; male infertility; recurrent pregnancy loss; preconception genetic testing; pre-implantation genetic testing; prenatal genetics; non-invasive prenatal testing; molecular genetics; cytogenetics; molecular cytogenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Forensic Genetics and DNA

edited by

Maria Saiz

submission deadline 20 Apr 2026 | 4 articles | Viewed by 3359 | Submission Open

Keywords: human identification; crime scene investigation; next generation sequencing; forensic investigative genetic genealogy; lineage markers; DNA methylation; disaster victim identification

(This special issue belongs to the Section Molecular Genetics and Genomics)

Pharmacogenomics and Pharmacoepigenomics in Autoimmune Diseases: How Close We Are to Personalised Medicine

edited by

Yiannis Vasilopoulos

and

Ioannis S. Vizirianakis

submission deadline 20 Apr 2026 | Viewed by 557 | Submission Open

Keywords: pharmacogenomics; pharmacoepigenomics; drug efficacy; drug toxicity; molecular pharmacology; autoimmune diseases

(This special issue belongs to the Section Pharmacogenetics)

Genetic Insights into Aging and Age-Related Diseases

edited by Monica Sanchez-Contreras

submission deadline 20 Apr 2026 | Viewed by 138 | Submission Open

Keywords: somatic mutations; aging; genomic instability; DNA damage; neurodegeneration; cancer

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomic and Molecular Landscapes of Cardiac Remodeling and Heart Failure

edited by Dorota Ciołczyk-Wierzbicka

submission deadline 20 Apr 2026 | Viewed by 116 | Submission Open

Keywords: heart failure; genomics; transcriptomics; epigenetics/chromatin remodeling; non-coding RNAs; myocardial fibrosis; cardiac regeneration; multi-omics & AI-driven bioinformatics; precision cardiology; translational therapeutics

(This special issue belongs to the Section Genetic Diagnosis)

Genetic and Molecular Mechanisms in Animal Reproduction

edited by

Xianfeng Yu

submission deadline 20 Apr 2026 | Viewed by 98 | Submission Open

Keywords: gamete; embryo; gene regulation; epigenetics; cloning; IVP; ET

(This special issue belongs to the Section Animal Genetics and Genomics)

Application of Genome-Wide Association Studies in Rare Diseases Research

edited by Menglu Liang and

Andrzej Ciechanowicz

submission deadline 25 Apr 2026 | 1 articles | Viewed by 629 | Submission Open

Keywords: rare disease genetics; statistical methods; genomic association; small sample inference; polygenic risk scores; cross-ancestry GWAS; gene– gene interaction; gene– environment interaction; disease biomarkers; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The Origin and Evolution of Genetic Code

edited by

Kenji Ikehara

submission deadline 25 Apr 2026 | Viewed by 105 | Submission Open

Keywords: origin of the genetic code; evolution of the genetic code; origin of gene; evolution of gene; origin of protein; evolution of protein; origin of life; evolution of life

(This special issue belongs to the Section Molecular Genetics and Genomics)

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