Special Issue "Genetics of Mitochondria and Cardiovascular Disease"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".

Deadline for manuscript submissions: 5 July 2023 | Viewed by 104

Special Issue Editors

Vascular Biology Lab., SASTRA Deemed University, Thanjavur 613401, Tamil Nadu, India
Interests: ischemic heart disease; diabetic cardiomyopathy; molecular and cellular cardiology; mitochondrial biology
Special Issues, Collections and Topics in MDPI journals
Cancer Genomics Laboratory, Department of Biotechnology, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India
Interests: breast cancer; leukemogenesis; cancer genomics; angiogenesis; epigenetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advances in genome sequencing and genetic testing help in understanding the genetic basis of multiple cardiac conditions, including arrhythmias that develop mainly due to channelopathies, ischemia, heart failure resulted from cardiomyopathies, myocardial infarction, ischemia reperfusion injury, lipid disorders, cardiac complications of neuromuscular conditions, and vascular disease. Mitohcondria serves as the power house of cells, occupying one third of cardiac cell volume, which emphasizes the high energy demand of the organ. In addition to the bioenergetics functions, mitochodnria plays a significant role in maintaining the homeostasis of cellular cations by regulating Ca2+, K+, and Na+ ions, which are critical for electrical activity and muscle contraction.

Mitochondrial DNA are susceptible to oxidative damage and can significantly contribute to the development and progression of different cardiovascular diseases by affecting cardiac energetics function or by acting as DAMP that further trigger inflammatory response. Unlike nuclear DNA damage, mitochondrial DNA damage cannot be effectively repaired. Acting as an epicentre for different cardio-protective signalling pathways, the dysfunction of mitochondria can impair the cardiac protective response and promote contractile dysfunction. This is complemented with an excessive production of free radicals via complex I and III during energy demand, and supply imbalance happens in different CVD especially in ischemic heart disease. The resulted radicals in turn damage the biomolecules leading to increased apoptosis, autophagy, and mitophagy. The co-existence of diseases like diabetes mellitus and hypertension can accelerate the deleterious cardiac events as well. Together with the technological advances especially in gene editing tools, investigations into mitochondria-targeting drugs and/or mitochondria replacement therapies are cautiously being pursued.

This Special Issue aims to highlight the importance of genetic alteration in different mitochondrial-encoded and nuclear-encoded genes that occur during the development of the diseases and possible future therapeutic approaches for the rescue of mitochondria dysfunction in different cardiovascular diseases. Additionally, the present issue may shed light into the genetic and epigenetic regulation of gene and its function in different cardiovascular diseases, that pave the way for the development of diagnostic markers and therapeutic strategies. To progress in the knowledge of such intricate issues, contributions by experts in the field in the form of research papers and critical reviews are called for.

We look forward to your expert contributions.

You may choose our Joint Special Issue in Cardiogenetics.

Dr. Gino A. Kurian
Dr. Nageswara Rao Dunna
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mitochondria
  • heart
  • heart failure
  • mitochhondrial DNA
  • atherosclerosis
  • myocardial infarction
  • myocardial ischemia reperfusion injury
  • mitochondrial genetics

Published Papers

This special issue is now open for submission.
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