Non-canonical Splicing and Their Implications in Normal Physiology and Cancer
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Technologies and Resources for Genetics".
Deadline for manuscript submissions: closed (30 July 2022) | Viewed by 6553
Special Issue Editors
Interests: RNA processing; gene fusion; chromosomal rearrangement; chimeric RNA; oncogene
Interests: RNA splicing; long noncoding chimeric RNAs; castration-resistant prostate cancer; cis-splicing of adjacent genes; chimeric circular RNAs; esophageal cancer
Special Issue Information
Dear Colleagues,
We would like to invite you to participate in this Special Issue, “Non-canonical Splicing and Its Implications in Normal Physiology and Cancer”.
RNA splicing is one of the major differences in RNA processing between eukaryotes and prokaryotes. Splicing describes a process that removes introns and connects exons together. Non-canonical splicing, however, describes phenomena that involve cryptic splice sites different from currently annotated exons and unconventional mechanisms that deviate from the well-defined rules of splicing.
With the advances of experimental and computational techniques, we now have an unprecedented view of RNA processing, revealing many previously unknown non-canonical splicing events. These include alternative splicing within a gene, circular RNAs resulting from back-splicing, chimeric RNAs due to intergenic splicing, etc. They represent new mechanisms to expand the functional genome, thus playing important roles in normal physiology. It has been estimated that about one third of human diseases are caused by mutations in splicing sites or aberrant splicing factors. Nevertheless, the proportion from non-canonical splicing is still unclear, with more and more works in the literature supporting its involvement in the pathology of diseases.
The purpose of this Special Issue is to host research and review papers on our molecular understanding of non-canonical splicing, their normal physiological roles, and their connection to diseases. New results, confirmatory results, and contradictory results will also be considered for publication.
Prof. Dr. Hui Li
Prof. Dr. Fujun Qin
Guest Editors
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Keywords
- chimeric RNA
- intergenic splicing
- back splicing
- alternative splicing
- cancer
- circular RNA
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