Gene Regulation of Calcium Channels in Health and Disease
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 302
Special Issue Editor
Special Issue Information
Dear Colleagues,
Calcium is one of the most versatile second messengers responsible for regulating a large number of diverse cellular and physiological functions, and calcium channels represent the primary pathway for mobilizing calcium ions from external and internal stores in both excitable and non-excitable cells. In order to regulate the amplitude, duration, and localization of the calcium signal, calcium channels are subject to a number of regulatory mechanisms that ensure their proper trafficking to and from cell membranes, and their gating properties. Additionally, the expression of calcium channels is subject to transcriptional control involving transcription factors, alternative splicing, and epigenetic regulations that ensure an important level of control of calcium homeostasis during embryonic and adult stages. Nonetheless, these mechanisms are often not perfect and can result in the emergence of multiple diseased states.
The goal of this Special Issue of Genes is to facilitate the dissemination of recent developments regarding the genetic regulation of calcium channels in health and diseased conditions. We invite submission for reviews, original articles, and short communications reporting the regulation of calcium channels at genetic or epigenetic levels.
Prof. Norbert Weiss
Guest Editor
Manuscript Submission Information
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Keywords
- Calcium channels
- Genetic control
- Epigenetic regulation
- Transcription factor
- Alternative splicing
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