Special Issue "Advances in Gel Science in the Asia Region: Current Trends and Opportunities"

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 2494

Special Issue Editors

Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia
Interests: drug delivery; nanogel; nanomedicine; pharmaceuticals; 3D printing
Department of Pharmaceutics, King Saud University, Riyadh 11451, Saudi Arabia
Interests: drug delivery; emulgel; phytopharmaceuticals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is aimed at providing an outline of the recent development of gel-based materials in the Asia region. A series of authors will share their views and results in gel science area (hydrogels, aerogels, xerogel, gel complexes and hybrids, etc.). Novel ideas and key findings will encourage gel experts to focus on future research and maximize the impact of the field across multiple disciplines.

Gel-based systems have become gradually more significant for biomedical applications due to their desirable biocompatibility and stability. The variability of gel structures (hydrogel, emulgel, lipogel, etc.) is helpful to achieve desirable attributes for utility in biomedical purposes. Additionally, structures can be modified depending on the interactions between components/polymers, their gelling mechanisms, gel formation conditions, etc. Recently, there has been growing interest in the design and characterization of multifunctional hydrogels and/or nanogels for different purposes, such as controlled drug delivery to personalized medicine including specialized tissue engineering. We encourage original articles, reviews, short communications, and prospects in the gel area, especially recent developments in the design and characterization of gels and their physicochemical characteristics, their utility in biomedical applications, and their future prospects.

Dr. Javed Ahmad
Dr. Syed Imam
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • gel science
  • biocompatibility
  • biomedical
  • drug delivery
  • evaluation
  • emulgels
  • hydrogels
  • nanogels
  • pseudoplastic
  • physicochemical properties
  • rheology
  • sol-gel
  • stimuli‐responsive
  • stability
  • thixotropy
  • nanotherapeutics

Published Papers (1 paper)

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Tamoxifen Citrate Containing Topical Nanoemulgel Prepared by Ultrasonication Technique: Formulation Design and In Vitro Evaluation
Gels 2022, 8(7), 456; https://doi.org/10.3390/gels8070456 - 21 Jul 2022
Cited by 6 | Viewed by 2070
The present study aims to design and develop a nanoemulgel formulation of Tamoxifen citrate (TAM), a water-insoluble, potent anticancer drug, using the spontaneous emulsification method to improve topical delivery, achieve high accumulation at the tumour site, and spare the healthy tissues. The oil-based [...] Read more.
The present study aims to design and develop a nanoemulgel formulation of Tamoxifen citrate (TAM), a water-insoluble, potent anticancer drug, using the spontaneous emulsification method to improve topical delivery, achieve high accumulation at the tumour site, and spare the healthy tissues. The oil-based selection was related to the TAM solubility, while the surfactant and co-surfactant were chosen based on the droplets’ thermodynamic stability and size. Afterwards, a pseudo-ternary phase diagram was built for the most promising formulation using two oils, olive and sesame, with a varied mix of Tween 40 as the surfactant and Trascutol HP as the co-surfactant (Smix), by the optimisation of experiments. The nanoemulsion (NE) formulations that were prepared were found to have an average droplet size of 41.77 ± 1.23 nm and 188.37 ± 3.53 nm, with suitable thermodynamic stability and physicochemical properties. Both olive and sesame oils are natural food additives due to their associated antioxidant effects; therefore, they showed no toxicity profile on breast cell lines (MCF-7, ATCC number HTB-22). The TAM-NE preparations revealed a prolonged and doublings superior cumulative percentage of in vitro release of TAM compared to TAM plain gel suspension over 24 h. The release data suggested that the Higuchi model was the best fitting kinetical model for the developed formulations of NE1, NE9, and NE18. The extended release of the drug as well as an acceptable amount of the drug permeated TAM via nanogel preparations suggested that nanoemulgel (NEG) is suitable for the topical delivery of TAM in breast cancer management. Thus, this work suggests that a nanogel of TAM can improve anticancer properties and reduce systemic adverse effects compared to a suspension preparation of TAM when applied in the treatment of breast cancer. Full article
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