Diagnosis and Management of Cardiac Disease in Iron Overload Conditions: Where Do We Currently Stand?
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".
Deadline for manuscript submissions: closed (30 November 2021)
Special Issue Editor
Special Issue Information
Dear Colleagues,
Since the identification of the adverse effects of iron overload states on cardiac physiology, much progress has been made, with the development of efficient, non-invasive diagnostic tools and the introduction of game-changing chelation therapies, which have had a substantial impact on patients' quality of life and, ultimately, their prognosis. As iron overload conditions may present with a broad clinical picture depending on their causes, ranging from ventricular remodelling to systolic and diastolic dysfunction but also to an infiltrative physiology, diagnosis and management are far from simplistic and unified.
In the present review, we describe the forms, pathophysiology and phenotypic expression of iron overload cardiomyopathies, describing the existing standard practice but also the outstanding challenges in the management of these conditions, which mainly concern young patients. Social parameters such as adherence to medical plans and impacts on the quality of life of patients with iron overload conditions will also be discussed.
Dr. Konstantinos Bratis
Guest Editor
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Keywords
- Iron overload cardiomyopathies
- Chelation treatment
- Cardiac imaging
- Sickle-cell disease
- Thalassaemia
- Haemochromatosis
- Transfusion-dependent patients
- Iron metabolism
