Special Issue "Pharmaceutical Crystallization"

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Biomolecular Crystals".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editors

Prof. Hiroshi Ooshima

Guest Editor
1. Professor Emeritus Osaka City University, Osaka, Japan
2. Kansai Chemical Engineering Co., Ltd., Hyogo, Japan
Interests: structure of supersaturated solution; crystal nucleation; industrial crystallization
Prof. Joop H. ter Horst
Website1 Website2
Guest Editor
University of Strathclyde, EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC), Glasgow, UK
Interests: industrial crystallization fundamentals; crystal nucleation; chiral separation and deracemization; continuous crystallization
Prof. Koichi Igarashi
Guest Editor
Osaka City University, Department of Applied Chemistry and Bioengineering, Osaka, Japan
Interests: industrial crystallization; continuous crystallization; crystal polymorphs; bio-assisted crystallization

Special Issue Information

Dear Colleagues,

Currently, about 80% of approved pharmaceuticals are small organic compounds with a molecular weight of less than roughly 500 g/mol. These compounds are used in the treatments of many types of diseases that plague humanity. Crystallization plays a major role in the manufacture of these compounds as it is a highly selective separation and purification technology resulting in a particulate product. The characteristics of a particulate pharmaceutical product, namely the kind of solid state, size, shape, and purity, are strongly related to pharmaceutical activity through important properties such as bioavailability.

The chemical structure of newly proposed small pharmaceutical molecules shows increasing complexity and, with this, an increasingly complex crystallization behavior. Therefore, the community continues to put strong efforts into obtaining fundamental crystallization knowledge. As an example, the association behavior of solute molecules in supersaturated solutions strongly influences the nucleation process but is not yet completely understood.

Industrial crystallization is a molecular-level process where molecules are incorporated into kinks of steps at growing crystal surfaces. Controlling the incorporation of molecules in such a macroscopic process is a challenge. While research on continuous pharmaceutical crystallization continues to be fruitful, progress must be made in modeling, monitoring, and control.

We would like this Special Issue of Crystals to provide a forum on the current state of pharmaceutical crystallization research by collecting contributions to the crystallization of pharmaceuticals on subjects including, but not limited to, the following:

  • Particulate pharmaceutical product characteristics: polymorphism, co-crystals, solvates, salts, chiral compounds, crystal size distribution, crystal morphology, purity.
  • Crystallization fundamentals: crystal nucleation, crystal growth, secondary nucleation, agglomeration, solution structure, chiral separation and deracemization.
  • Industrial crystallization: batch-wise and continuous crystallization; crystallization process monitoring, modeling, and control; crystallization process design; hybrid crystallization processes. 

Prof. Hiroshi Ooshima
Prof. Joop H. ter Horst
Prof. Koichi Igarashi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Polymorphism
  • Crystal size distribution control
  • Crystal morphology control
  • Co-crystals
  • Chiral separation
  • Structure of supersaturated solution
  • Crystal nucleation
  • Crystal growth
  • Continuous crystallization
  • Crystallization process monitoring
  • Others

Published Papers

This special issue is now open for submission.
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