Special Issue "Complementary Techniques in Pharmaceutical Solid-State Analysis"

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Biomolecular Crystals".

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editor

Prof. Patrizia Rossi
Guest Editor
Department of Industrial Engineering, University of Firenze, Italy
Interests: solid-state structure–properties relationship of different classes of compounds; XRPD; polymorphism and pseudopolymorphism; API

Special Issue Information

Dear Colleagues,

It is a real pleasure for me to invite you to contribute to this Crystals Special Issue entitled: “Complementary Techniques in Pharmaceutical Solid-State Analysis”.
It is well known that solid-state analysis plays a key role in the study of compounds of pharmaceutical interest. In fact, it helps to understand a multiplicity of phenomena such as polymorphism and pseudopolymorphism, intermolecular interactions, and solvation and desolvation, just to name a few. Different techniques such as X-ray diffraction (XRD), solid state NMR (SSNMR) and differential scanning calorimetry (DSC) are of primary importance in this field and have proven to be excellent complementary tools. SSNMR, for example, may help in obtaining molecular information such as spatial proximities, disorder, solvation, and a number of independent molecules when crystals of high quality for single crystal X-ray diffraction are not available. Thermal analysis techniques, such as DSC and TGA, may be combined with variable temperature X-ray powder diffraction in order to obtain information about the stability of a given phase.

Finally, theoretical calculations are of fundamental importance to fully rationalize phase transformations and disorder in API crystal structures.
The Special Issue on “Complementary Techniques in Pharmaceutical Solid-State Analysis” is intended to cover the broad field of solid-state analysis of compounds of pharmaceutical interest with a particular attention to all those techniques that may synergistically collaborate with X-ray diffraction (single crystal and powder XRD) studies.

Prof. Patrizia Rossi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Active pharmaceutical ingredients
  • X-ray diffraction
  • SS-NMR
  • Computational methods
  • Complementary techniques

Published Papers

This special issue is now open for submission.
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