Special Issue "Advance in Electrochemiluminescence Immunoassay"

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Optical Chemical Sensors".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 83

Special Issue Editor

Prof. Dr. Xiaoquan Lu
E-Mail Website
Guest Editor
Key Laboratory of Bioelectrochemistry & Environmental Analysis of Gansu Province, College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou 730070, China
Interests: Electrochemiluminescence; immunosensors

Special Issue Information

Dear Colleagues,

Since the twentieth century, with the development of science and technology and emergence of new technological models we are faced with new opportunities and challenges in disease diagnosis, analysis, and detection, to realize biomolecular analysis and detection is important to study the origin of disease. Electrochemiluminescence (ECL) immunosensors are biosensing systems that combine ECL and immunological technologies. The emitter converts the signal conveyed by antigen-antibody specific interaction into an ECL signal by forming an excited state and returning to the ground state and emitting light when a potential is applied at the electrode, a novel labeled sensing technique for immunoassays. It combines the benefits of both, with excellent specificity, sensitivity, quick analytical detection, a simple operating system, and little background interference. It has prospective applications in the domains of cancer detection and illness diagnostics because of its unique characteristics, allowing ultrasensitive detection of biologically active chemicals (e.g. proteins, targeted drugs, toxicants). Simultaneously, luminous materials such as bipyridyl ruthenium and its derivatives, luminol, quantum dots, and functionalized nanomaterials (semiconductor nano, metal nano, and composite nanomaterials) are frequently exploited in the development of ECL immunosensors. There are currently two types of ECL-based immunosensors for target detection: "sandwich" and "label-free" ECL immunosensors, both of which are based on a particular antibody-antigen immune response. Both types of immunosensors are based on specific immune reactions between antibody and antigen. However, numerous hurdles remain in the development of ECL immunosensors, including the poor biocompatibility of ECL luminophores, the complicated electrode modification procedure, and the investigation of signal amplification methodologies. As a result, additional research into innovative ECL materials with outstanding biocompatibility, high catalytic efficiency, and physiological harmlessness is essential for the advancement of ECL immunosensing. ECL immunosensing will soon play a vital role in biological sample detection, environmental analysis, and early clinical diagnosis, capable of real-time, accurate analytical detection of trace samples and integrated with other methods.

Prof. Dr. Xiaoquan Lu
Guest Editor

Manuscript Submission Information

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Keywords

  • Electrochemiluminescence (ECL)
  • immunosensors
  • biosensing systems
  • innovative ECL materials
  • "sandwich"/"label-free" ECL immunosensors

Published Papers

There is no accepted submissions to this special issue at this moment.
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