Special Issue "Nucleic Acid Modifying Enzymes"

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".

Deadline for manuscript submissions: 15 May 2021.

Special Issue Editor

Prof. Dr. David Hornby
Guest Editor
University of Sheffield, Sheffield, United Kingdom
Interests: Understanding the mechanism of nucleic acid modifying enzymes together with methods for nucleic acid purification

Special Issue Information

Dear Colleagues,

There is a long-standing debate over the origins of biological catalysis and the interplay between enzymes derived from polypeptides, and those derived from nucleic acids, in particular RNA. As the life sciences community gathers genome sequences on a daily basis, our understanding of the different chemistries underpinning these genomes becomes increasingly significant. For example, the genomes of bacteriophage and viruses comprise either DNA or RNA, and the nucleic acid may toggle between single-strands or double strands, with hybrids forms in between. In addition, both RNA- and DNA-based genomes are subject to chemical modifications that confer enhanced levels of function, support structural diversity, and promote molecular interactions, in particular with proteins.

Since the discovery of RNA-mediated catalysis in the 1980s, our understanding of the importance of catalysis in the origin of life on earth and its subsequent role in mediating and propagating life, has led to a deeper understanding of the way in which living organisms have successfully harnessed the fundamental principles of chemical catalysis to support evolution. In this issue, we focus on the principles and diversity of catalysis associated with the modification of nucleic acids. Since the power of technologies, such as mass spectrometry, have been turned to nucleic acid enzymology in its widest sense, the basis for elucidating the biological role of such modifications has been transformed. This Special Issue will provide insights into this expanding and important field.

Prof. Dr. David Hornby
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Origins of Catalysis
  • Metal ions
  • RNA enzymes (ribozymes)
  • Metallo-proteins
  • Enzyme evolution
  • Active site chemistry
  • Replication enzymes
  • Biological catalysts

Published Papers

This special issue is now open for submission.
Back to TopTop