Special Issue "Recent Advances in Click Chemistry: New Catalysts and High Reaction Rates"

A special issue of Catalysts (ISSN 2073-4344).

Deadline for manuscript submissions: 15 November 2019.

Special Issue Editor

Guest Editor
Dr. Jorge Escorihuela Fuentes Website E-Mail
Department of Organic Chemistry, University of Valencia, 46100 Valencia, Spain
Interests: organic chemistry; polymer electrolytes; ionic liquids (ILs); ionic-exchange membranes; ionic conductivity; electrochemical impedance spectroscopy (EIS); mixed-matrix membranes (MMMs); membrane–electrode assembly (MEA); protonic-exchange membrane fuel cell applications (PEMFC); fuel cell performance; direct methanol fuel cells (DMFCs); batteries; supercapacitors; composite membranes containing PEDOT; polypyrrol; graphene

Special Issue Information

Dear Colleagues,

The past decade has witnesed an increasing growth in the number of so-called “click” reactions, which refer to synthetic methods with high yields and fast reaction rates, a high degree of regioselectivity and whose products are readily purified. Since the coining of this term by Sharpless and co-workers in 2001, click chemistry has vastly improved our ability to rapidly functionalize a wide variety of molecules for diverse applications in synthetic organic chemistry, pharmaceutical chemistry, and the biological and material sciences.

Since the introduction of the copper-catalyzed azide alkyne cycloaddition (CuAAC), significant progress has been shown by transition metal catalysts in the development of novel click methodologies with high catalytic efficiency. More recently, metal-free click reactions have emerged replacing the metal catalyst by strained reagents. In this regard, strain-promoted azide-alkyne cycloaddition (SPAAC), inverse electron-demand Diels–Alder (IEDDA), tetrazine-trans-cyclooctene (TCO)/cyclopropene clic and strain-promoted oxidation-controlled cyclooctyne-1,2-quinone cycloaddition (SPOCQ) have been widely used due to their fast kinetics.

This Special Issue of Catalysts aims to cover recent progress and advances in the field of click chemistry. This issue is not restricted to the design and synthesis of novel catalysts and their applications in the development of click methodologies, but also includes recent progress concerning the aforementioned metal-free click methodologies, in research areas such as catalysis, medicinal chemistry, biology, supramolecular chemistry, surface modification, material science and nanotechnology. I, as Guest Editor of this Special Issue of Catalysts, strongly encourage colleagues to submit manuscripts for this Special Issue that will promote the most recent advances in this powerful synthetic technology.

Dr. Jorge Escorihuela
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • click chemistry
  • CuAAC
  • transition metal
  • strain promoted
  • metal-free
  • supramolecular chemistry
  • catalysis
  • pharmaceutical chemistry
  • surface modification
  • material science
  • nanotechnology

Published Papers

This special issue is now open for submission.
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