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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Survivorship Following Childhood, Adolescent and Young Adult Cancer

edited by Magdalena Balcerek and Judith Gebauer

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2883 | Submission Open

Keywords: cancer survivorship; late effects; long-term follow-up care; supportive care; health prevention and promotion

(This special issue belongs to the Section Pediatric Oncology)

Recent Trends in the Development of Theranostics and Multifunctional Tracers in Oncology

edited by

Olaf Prante

submission deadline 20 Jan 2026 | Viewed by 266 | Submission Open

Keywords: multifunctional radiopharmaceuticls; PET/CT; multimodal imaging; cancer treatment

(This special issue belongs to the Section Methods and Technologies Development)

The Prospect of Nanobiotechnology in Cancers

edited by

Wenpan Li

submission deadline 20 Jan 2026 | Viewed by 221 | Submission Open

Keywords: nanobiotechnology; cancer therapy; targeted drug delivery; tumor microenvironment

(This special issue belongs to the Section Methods and Technologies Development)

Recent Updates on Imaging and Staging of Gynecologic Cancers

edited by

David Mutch

and Alexander B. Olawaiye

submission deadline 21 Jan 2026 | 2 articles | Viewed by 2992 | Submission Open

Keywords: imaging; surgical staging; molecular prognostic features; mortality; prognosis

(This special issue belongs to the Section Methods and Technologies Development)

Roles of the Tumor Microenvironment on Liquid Biopsy (2nd Edition)

edited by

Dario Marchetti

submission deadline 22 Jan 2026 | 1 articles | Viewed by 960 | Submission Open

Keywords: liquid biopsy; CTCs; CTC characterization and CTC clustering; ctDNA and ctDNA profiling; exosomes/extracellular vesicles and biology; tumor microenvironment; bone marrow cellular/molecular heterogeneity; CTCs/blood/BM cells crosstalk; analytical validity; clinical validity; and clinical utility of liquid biopsy; liquid biopsy interplaying dormancy and metastasis

(This special issue belongs to the Section Tumor Microenvironment)

Advancements in Salivary Gland Tumors Management: From Diagnostic Imaging to Treatment Strategies

edited by Wioletta Pietruszewska, Małgorzata Wierzbicka and

Boguslaw Mikaszewski

submission deadline 22 Jan 2026 | Viewed by 299 | Submission Open

Keywords: salivary gland tumors; MRI; CT; and PET; minimally invasive approaches

(This special issue belongs to the Section Cancer Therapy)

Innovative Immunotherapies: CAR-T Cell Therapy for Cancers: 2nd Edition

edited by

Shebli Atrash

submission deadline 23 Jan 2026 | 3 articles | Viewed by 9923 | Submission Open

Keywords: CAR-T; NK-CAR; immunotherapy; cancer; resistance mechanisms

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Targeting Hallmarks of Cancer

edited by

Carlos Pérez Plasencia

submission deadline 25 Jan 2026 | Viewed by 788 | Submission Open

Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer

(This special issue belongs to the Section Cancer Biomarkers)

Towards a Personalized Medicine for the Diagnosis and Management of Gynecological Cancers

edited by

Diego Raimondo

and Gabriele Centini

submission deadline 30 Jan 2026 | 3 articles | Viewed by 22499 | Submission Open

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Advance of Pencil Beam Scanning Proton Beam Therapy in Cancers

edited by

Haibo Lin

, Richard A. Amos and Heng Li

submission deadline 30 Jan 2026 | 7 articles | Viewed by 16998 | Submission Open

Keywords: proton therapy; pencil beam scanning; robustness; adaptive radiotherapy; imaging guidance; radiobiological model; FLASH radiotherapy; spatially fractionated radiotherapy (SFRT); proton arc

(This special issue belongs to the Section Cancer Therapy)

Cancer Disparities: Biological, Social, and Environmental Determinants

edited by

Riffat Mehboob

and

Miguel Muñoz

submission deadline 30 Jan 2026 | 3 articles | Viewed by 7697 | Submission Open

Keywords: cancer epidemiology; cancer etiology; environmental factors; screening and diagnostics; SDGs

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in the Treatment of Upper Gastrointestinal Cancer

edited by Sang-ho Jeong and

Jae-seok Min

submission deadline 30 Jan 2026 | 2 articles | Viewed by 5988 | Submission Open

Keywords: upper gastrointestinal cancer; surgery therapy; chemotherapy therapy; radiation therapy

(This special issue belongs to the Section Cancer Therapy)

Protein Structure and Cancer—2nd Edition

edited by

Michalis Aivaliotis

submission deadline 30 Jan 2026 | Viewed by 241 | Submission Open

Keywords: protein structure dynamics; structural cancer biology; protein pathways in cancer; structure– function alterations; in silico protein structure prediction; protein interactions; cancer mutations and protein structure alterations

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Drug Delivery for Cancer Therapy

edited by

Ashakumary Lakshmikuttyamma

submission deadline 31 Jan 2026 | 9 articles | Viewed by 45363 | Submission Open

Keywords: cancer; oncology; therapeutic target; drug resistance; immunotherapy; chemotherapy; small molecule inhibitors; drug delivery; nanoparticle

(This special issue belongs to the Section Cancer Drug Development)

How COVID-19 Affects Cancer Patients

edited by

Maria Fiore

submission deadline 31 Jan 2026 | 15 articles | Viewed by 37695 | Submission Open

Keywords: COVID-19; pandemic; cancer; impact; incidence; mortality; lethality; disparities; gender

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Surgical Advances in Cancer Treatments: Exploring Innovative Approaches and Emerging Perspectives

edited by

and

submission deadline 31 Jan 2026 | 17 articles | Viewed by 36697 | Submission Open

Keywords: surgical oncology; surgical innovation; image-guided surgery; robotic-assisted surgery; multidisciplinary oncology; surgical outcomes research; precision surgery; healthcare economics; surgical training and simulation

(This special issue belongs to the Section Cancer Therapy)

Genetics and Epigenetics of Gynecological Cancer

edited by

Carmela De Marco

submission deadline 31 Jan 2026 | 10 articles | Viewed by 33020 | Submission Open

Keywords: gynecologic cancers; epigenetics; genetics; immunogenetics; predisposing mutations; biomarkers; targeted therapies; chemoresistance

(This special issue belongs to the Section Cancer Pathophysiology)

CAR T Cells in Lymphoma and Multiple Myeloma

edited by

Javier Munoz

and

Julia Erin Wiedmeier-Nutor

submission deadline 31 Jan 2026 | 7 articles | Viewed by 29034 | Submission Open

Keywords: multiple myeloma; lymphoma; CAR T therapy; bi-specific antibodies; cellular therapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Screening, Early Detection and Prevention of Hepato-Pancreato-Biliary (HPB) Cancers

edited by Zaed Z.R. Hamady

submission deadline 31 Jan 2026 | 7 articles | Viewed by 26715 | Submission Open

Keywords: hepatobiliary cancer; pancreatic cancer; early detection; diagnosis; screening; prevention

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Thyroid Cancer: Diagnosis, Prognosis and Treatment (2nd Edition)

edited by

Luca Giovanella

and

Petra Petranović Ovčariček

submission deadline 31 Jan 2026 | 9 articles | Viewed by 20398 | Submission Open

Keywords: thyroid cancer; ultrasound; molecular imaging; fine-needle aspiration cytology; thyroidectomy; radioactive iodine; radioiodine-refractory thyroid cancer; tyrosine kinase inhibitors

(This special issue belongs to the Section Cancer Therapy)

Emerging Research on Primary Brain Tumors

edited by Jacob S Young and Mitchel S. Berger

submission deadline 31 Jan 2026 | 6 articles | Viewed by 19559 | Submission Open

Keywords: molecular biomarkers; drug delivery; immunotherapy; personalized medicine; targeted therapies; glioma

(This special issue belongs to the Section Cancer Therapy)

Empowering Cancer Survivors: A Comprehensive Approach to Supportive Care Through Pharmacological and Non-Pharmacological Approaches Including Exercise, Physical Activity and Nutrition

edited by Kellie Toohey

submission deadline 31 Jan 2026 | 11 articles | Viewed by 17627 | Submission Open

Keywords: cancer; physical activity; exercise; supportive care; holistic care; rehabilitation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Pathology and Treatment of Triple-Negative Breast Cancer

edited by

Ramadevi Subramani

submission deadline 31 Jan 2026 | 4 articles | Viewed by 13198 | Submission Open

(This special issue belongs to the Section Cancer Pathophysiology)

The Tumor Microenvironment: Interplay Between Immune Cells

edited by Jared Rowe and Kristen E. Pauken

submission deadline 31 Jan 2026 | 5 articles | Viewed by 11557 | Submission Open

Keywords: tumor immune microenvironment; metabolic microenvironment; immune cells

(This special issue belongs to the Section Tumor Microenvironment)

Implementation of Physical Activity Promotion in Cancer Care

edited by Sarah Hardcastle

submission deadline 31 Jan 2026 | 4 articles | Viewed by 11221 | Submission Open

Keywords: physical activity; cancer survivors; behaviour change; interventions; cancer care; implementation; health

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Gynecological Cancer: Prevention, Diagnosis, Prognosis and Treatment

edited by Joanna P. Kacperczyk-Bartnik, Tibor Andrea Zwimpfer and

Michał Ciebiera

submission deadline 31 Jan 2026 | 7 articles | Viewed by 10008 | Submission Open

Keywords: gynecological cancer; ovarian cancer; cervical cancer; endometrial cancer; early diagnosis; cancer prevention; prognosis; molecular mechanisms; personalized medicine; novel therapies

(This special issue belongs to the Section Clinical Research of Cancer)

Recent Advances and Challenges in Breast Cancer Surgery: 2nd Edition

edited by

Antonio Piñero-Madrona

submission deadline 31 Jan 2026 | 6 articles | Viewed by 9981 | Submission Open

Keywords: breast cancer surgery; axillary management; sentinel node oncoplastic surgery; reconstructive surgery; surgical technology; cancer risk reduction surgery; radio-guided surgery

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Oncology Imaging: 2nd Edition

edited by

Li Liu

and

Yicheng Ni

submission deadline 31 Jan 2026 | 4 articles | Viewed by 8518 | Submission Open

Keywords: medical imaging; cancer; oncology; molecular imaging; theragnostics

(This special issue belongs to the Section Methods and Technologies Development)

Biomarkers and Targeted Therapy in Malignant Pleural Mesothelioma

edited by

Susana Cedrés

submission deadline 31 Jan 2026 | 4 articles | Viewed by 8406 | Submission Open

Keywords: malignant mesothelioma; target therapy; biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Cancer Screening and Primary Care

edited by Marievelisse Soto-Salgado

submission deadline 31 Jan 2026 | 6 articles | Viewed by 7517 | Submission Open

Keywords: screening amenable cancers; screening; primary care; disparities in cancer care; cancer outcomes

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Exploring Skin Cancer: Insights into New Diagnostic, Prognostic, and Therapeutic Strategies

edited by

Emi Dika

submission deadline 31 Jan 2026 | 5 articles | Viewed by 7323 | Submission Open

Keywords: melanoma; non-melanoma skin cancer; NMSC; Merkel cell carcinoma; tumor microenvironment; prognosis; treatment

Advances in the Use of PET/CT and MRI in Prostate Cancer

edited by Carmelo Caldarella

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5776 | Submission Open

Keywords: PET/CT; MRI; prostate cancer; radiomic; receptor-targeted radiopharmaceuticals

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Apoptosis and Autophagy in Cancer

edited by

Souren Paul

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5480 | Submission Open

Keywords: apoptosis; cell death; tumor

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Studies and Outcomes in Urologic Cancer

edited by Nikolaos Pyrgidis

submission deadline 31 Jan 2026 | 5 articles | Viewed by 5198 | Submission Open

Keywords: urologic cancer; clinical outcomes; prostate cancer; urothelial cancer; kidney cancer; survival analysis; treatment response; quality of life; novel therapies; oncology

(This special issue belongs to the Section Clinical Research of Cancer)

Prediction of Melanoma

edited by

Irene Stefanaki

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4427 | Submission Open

Keywords: melanoma; melanoma genetics; biomarkers; predictive tools; risk prediction; risk factors; artificial intelligence

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Post-Neoadjuvant Strategies in Breast Cancer (2nd Edition)

edited by

Edwin Bölke

, Tanja Fehm and

Stefanie Corradini

submission deadline 31 Jan 2026 | 1 articles | Viewed by 3894 | Submission Open

Keywords: chemotherapy; prospective trials; clinical investigation; breast tumor; local recurrence; overall survival

(This special issue belongs to the Section Cancer Therapy)

Minimally Invasive Approaches in Urological Oncology: Current Trends and Innovations

edited by

Alchiede Simonato

and

Nicola Pavan

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3457 | Submission Open

Keywords: minimally invasive; robotic; laparoscopic; uro-oncology; prostate cancer; bladder cancer; kidney cancer; testicular cancers; quality of life; penile cancer

(This special issue belongs to the Section Clinical Research of Cancer)

Recent Advances in Nanomedicine-Based Cancer Immunotherapy

edited by Navin Kumar Verma,

Rajeev Parameswaran

and

Manash Paul

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2977 | Submission Open

Keywords: cancer nano-therapy; nano-enabled therapeutic; immune checkpoint inhibitors; tumor immunosuppression; adoptive cell therapy; CAR T-cell therapy; tumor-infiltrating lymphocyte therapy; monoclonal antibody therapy for cancer; cancer vaccines; immune system modulators

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Computational Research in Cancer Neuroscience

edited by Shaolei Teng

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2957 | Submission Open

Keywords: machine learning; large language models; protein structure modeling; omics data analysis; neural– cancer communication; tumor microenvironments; personalized medicine; targeted therapies; cancer neuroscience

(This special issue belongs to the Section Methods and Technologies Development)

Novel Perspectives in Hepato-Biliary and Pancreatic Cancer

edited by Tudor Mocan and Emil-Ioan Moiș

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2891 | Submission Open

Keywords: HCC; cholangiocarcinoma; surgery; biliary drainage; pancreatic cancer; combination therapies

(This special issue belongs to the Section Cancer Therapy)

Advances and Future Developments in Liver Transplantation for Cancers: 2nd Edition

edited by

Nicolas Golse

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2756 | Submission Open

Keywords: machine perfusion; marginal graft; split liver; immunotherapy; auxiliary liver transplantation; digital twin; modeling; organoid

(This special issue belongs to the Section Transplant Oncology)

Clinical Trials and Outcomes for Non-Small Cell Lung Cancer

edited by

Ana Rodrigues

and

António Araújo

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2745 | Submission Open

Keywords: non-small cell lung cancer; oncogenic alterations; clinical trial; systemic therapy; targeted therapy; immunotherapy; radiotherapy; real-world data; surgery; drug development

(This special issue belongs to the Section Clinical Research of Cancer)

Cancers Hijack Immune Surveillance and Tumor Microenvironment Leading to Immune Evasion

edited by

Yona Keisari

, Viktor Umansky and

Rostyslav Bilyy

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2614 | Submission Open

Keywords: anti-tumor immunity; cancer immunotherapy; immune evasion; immune response modulation; immunosuppression; immune surveillance; manipulating IR components function and migration; metabolic modulation of the TME; metabolic reprogramming; tumor-associated immune cells; tumor microenvironment (TME)

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Head and Neck Cancer: Survivorship Challenges and Therapeutic Approaches

edited by

Lucía Ortiz-Comino

, Avraham Eisbruch and

Ángela González-Santos

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2137 | Submission Open

Keywords: head and neck cancer; supportive care; survivorship care; physiotherapy; quality of life; lifestyle interventions

(This special issue belongs to the Section Cancer Therapy)

Radiosensitivity and Radiotoxicity in Cancer

edited by

Alexandros Georgakilas

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1965 | Submission Open

Keywords: radiation therapy; clinical outcome; radiosensitivity; radiotoxicity; biomarkers; bioinformatics; systems biology

(This special issue belongs to the Section Methods and Technologies Development)

Advanced Strategies in the Care of Hepatocellular Carcinoma Patients (2nd Edition)

edited by

Matteo Donadon

and

Guido Torzilli

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1648 | Submission Open

Keywords: hepatocellular carcinoma; hepatic resection; hepatectomy; liver resection; liver surgery; parenchymal-sparing liver surgery; intraoperative ultrasound; liver-specific magnetic resonance imaging; trans-arterial therapy; liver function; FibroScan

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advanced Glycation End-Products and Its Receptors in Cancer Progression

edited by Bhaumik B. Patel

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1537 | Submission Open

Keywords: advanced glycation end products; toxic advanced glycation end products; receptor for advanced glycation end products (RAGEs); glycosaminoglycans; cancer; cancer stem cells (CSCs); tumor immune microenvironment (TME)

(This special issue belongs to the Section Tumor Microenvironment)

Novel Approaches in the Management of Gynecological Cancers

edited by

Mikel Gorostidi

Martina Aida Angeles

and

Ignacio Zapardiel

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1425 | Submission Open

Keywords: gynecological cancer; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; surgical management; clinical management

(This special issue belongs to the Section Cancer Therapy)

Updates on Imaging of Common Urogenital Neoplasms 2nd Edition

edited by Athina C Tsili

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1417 | Submission Open

Keywords: urogenital neoplasms; renal cell carcinoma; prostatic neoplasms; urinary bladder neoplasms; testicular neoplasms; uterine neoplasms; ovarian neoplasms; ultrasonography; computed tomography; magnetic resonance imaging

(This special issue belongs to the Section Methods and Technologies Development)

Emerging Technologies in Thoracic Surgery

edited by Filippo Lococo and

Carolina Sassorossi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1363 | Submission Open

Keywords: lung cancer; molecular biology; liquid biopsy; immunotherapy; precision surgery; minimally invasive surgery; new technologies; artificial intelligence

(This special issue belongs to the Section Methods and Technologies Development)

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