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Plasmonic Waveguide Biosensors
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Special Issue "Plasmonic Waveguide Biosensors"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: 30 September 2023 | Viewed by 5631

Special Issue Editor

Prof. Dr. Lai-Kwan Chau

E-Mail Website
Guest Editor
Department of Chemistry and Biochemistry, National Chung Cheng University, Chiayi 62102, Taiwan
Interests: biosensors; waveguide sensors; plasmonics; surface-enhanced Raman scattering; nanomaterials; noble metal nanoparticles; sol–gel; self-assembled monolayer; new biosensing methods applied to biomedicine, environmental monitoring, agriculture, food safety testing, and biointeraction analysis

Special Issue Information

Dear Colleague,

Plasmonics is an emerging branch of nanophotonics that has shown an increasing impact in bioanalysis. There are two types of surface plasmon resonances (SPRs)—the more traditional propagating SPR (PSPR) and the more recent localized SPR (LSPR) based on nanostructures. Both types of SPR sensing techniques have been applied to a wide range of biomolecular interactions and quantitation. The plasmonic nanostructures are also very attractive for surface-enhanced spectroscopies, such as surface-enhanced Raman scattering (SERS), surface-enhanced absorption (SEA), and surface-enhanced fluorescence (SEF). Waveguides are thin films or cylindrical microstructures that effectively conduct light. Their small size, flexible geometry, ability to channel light over a long distance, and noise immunity make waveguides ideal for chemical and biochemical sensing. In particular, the sensing sensitivity increases as the interaction length increases. The smart combination of the two branches, plasmonics and waveguide, typically has a few orders of magnitude better detection limit than that of either one alone, potentially leading to a new generation of biosensors.

This Special Issue is focused on the recent progress in plasmonic waveguides (PWs) as a platform for biochemical analysis. We invite authors to submit manuscripts that help to advance plasmonic waveguide sensing platforms and their applications in various bioanalytical fields. Articles may include, but are not limited to, the following topics:

  • fiber optic PSPR biosensors;
  • planar-waveguide-based PSPR biosensors;
  • fiber optic LSPR biosensors;
  • planar wavguide-based LSPR biosensors;
  • plasmonic waveguide interferometer biosensors, including guided mode resonance;
  • plasmonic waveguides for SERS, SEA, and SEF developments;
  • integration of microfluidics with plasmonic waveguides for biosensing;
  • other waveguide structures and sensors that have a potential to be integrated with plasmonics;
  • new nanomaterials for PW biosensors;
  • application of PW in biomedical applications;
  • application of PW in agricultural and food safety testing applications;
  • application of PW in environmental applications;
  • application of PW in drug discovery;
  • application of PW in biointeraction analysis.

Prof. Dr. Lai-Kwan Chau
Guest Editor

If you want to learn more information or need any advice, you can contact the Special Issue Editor Jessica Zhou via <[email protected]> directly.

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (4 papers)

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Article
Trace Determination of Grouper Nervous Necrosis Virus in Contaminated Larvae and Pond Water Samples Using Label-Free Fiber Optic Nanoplasmonic Biosensor
by
Yuan-Yu Chen
,
Chih-Lu Wu
,
Chia-Wei Hsu
,
Chih-Hui Wang
,
Chung-Rui Su
,
Chun-Jen Huang
,
Hau-Ren Chen
,
Lai-Kwan Chau
and
Shau-Chun Wang
Biosensors 2022, 12(10), 907; https://doi.org/10.3390/bios12100907 - 21 Oct 2022
Viewed by 621
Abstract
We developed a fast (<20 min), label-free fiber optic particle plasmon resonance (FOPPR) immunosensing method to detect nervous necrosis virus (NNV), which often infects high-value economic aquatic species, such as grouper. Using spiked NNV particles in a phosphate buffer as samples, the standard [...] Read more.
We developed a fast (<20 min), label-free fiber optic particle plasmon resonance (FOPPR) immunosensing method to detect nervous necrosis virus (NNV), which often infects high-value economic aquatic species, such as grouper. Using spiked NNV particles in a phosphate buffer as samples, the standard calibration curve obtained was linear (R2 = 0.99) and the limit of detection (LOD) achieved was 2.75 × 104 TCID50/mL, which is superior to that obtained using enzyme-linked immunosorbent assay (ELISA). By using an enhancement method called fiber optic nanogold-linked immunosorbent assay (FONLISA), the LOD can be further improved to <1 TCID50/mL, which is comparable to that found by the conventional qPCR method. Employing the larvae homogenate samples of NNV-infected grouper, the results obtained by the FOPPR biosensor agree with those obtained by the quantitative polymerase chain reaction (qPCR) method. We also examined pond water samples from an infected container in an indoor aquaculture facility. The lowest detectable level of NNV coat protein was found to be 0.17 μg/mL, which is one order lower than the LOD reported by ELISA. Therefore, we demonstrated the potential of the FOPPR biosensor as an outbreak surveillance tool, which is able to give warning indication even when the trend of larvae death toll increment is still not clear. Full article
(This article belongs to the Special Issue Plasmonic Waveguide Biosensors)
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Article
Ultrasensitive and Rapid Detection of N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) Using Fiber Optic Nanogold-Linked Immunosorbent Assay
by
Han-Long Liu
,
Yen-Ta Tseng
,
Mei-Chu Lai
and
Lai-Kwan Chau
Biosensors 2022, 12(9), 746; https://doi.org/10.3390/bios12090746 - 09 Sep 2022
Cited by 1 | Viewed by 1001
Abstract
The N-terminal pro-brain natriuretic peptide (NT-proBNP) is considered an important blood biomarker for heart failure. Herein, we report about a fiber optic nanogold-linked immunosorbent assay (FONLISA) method for the rapid, sensitive, and low-cost detection of NT-proBNP. The method is based on a sandwich [...] Read more.
The N-terminal pro-brain natriuretic peptide (NT-proBNP) is considered an important blood biomarker for heart failure. Herein, we report about a fiber optic nanogold-linked immunosorbent assay (FONLISA) method for the rapid, sensitive, and low-cost detection of NT-proBNP. The method is based on a sandwich immunoassay approach that uses two monoclonal NT-proBNP antibodies, a capture antibody (AbC), and a detection antibody (AbD). AbD is conjugated to a free gold nanoparticle (AuNP) to form the free [email protected]D conjugate, and AbC is immobilized on an unclad segment of an optical fiber. The detection of analyte (A), in this case NT-proBNP, is based on the signal change due to the formation of an [email protected]D–A–AbC complex on the fiber core surface, where a green light transmitted through the optical fiber will decrease in intensity due to light absorption by AuNPs via the localized surface plasmon resonance effect. This method provides a wide linear dynamic range of 0.50~5000 pg·mL−1 and a limit of detection of 0.058 pg·mL−1 for NT-proBNP. Finally, the method exhibits good correlation (r = 0.979) with the commercial central laboratory-based electrochemiluminescent immunoassay method that uses a Roche Cobas e411 instrument. Hence, our method is potentially a suitable tool for point-of-care testing. Full article
(This article belongs to the Special Issue Plasmonic Waveguide Biosensors)
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Article
Multimode Fano Resonances Sensing Based on a Non-Through MIM Waveguide with a Square Split-Ring Resonance Cavity
by
Jianfeng Chen
,
Xinyu Lian
,
Ming Zhao
and
Chenbo Xie
Biosensors 2022, 12(5), 306; https://doi.org/10.3390/bios12050306 - 06 May 2022
Cited by 1 | Viewed by 1133
Abstract
In this article, a non-through metal–insulator–metal (MIM) waveguide that can excite fivefold Fano resonances is reported. The Fano resonances are obtained by the interaction between the modes excited by the square split-ring resonator (SSRC) and the bus waveguide. After a detailed analysis of [...] Read more.
In this article, a non-through metal–insulator–metal (MIM) waveguide that can excite fivefold Fano resonances is reported. The Fano resonances are obtained by the interaction between the modes excited by the square split-ring resonator (SSRC) and the bus waveguide. After a detailed analysis of the transmission characteristics and magnetic field strength of the structure using the finite element method (FEM), it was found that the independent tuning of Fano resonance wavelength and transmittance can be achieved by adjusting the geometric parameters of SSRC. In addition, after optimizing the geometric parameters, the refractive index sensing sensitivity (S) and figure of merit (FOM) of the structure can be optimal, which are 1290.2 nm/RIU and 3.6 × 104, respectively. Additionally, the annular cavity of the MIM waveguide structure can also be filled with biomass solution to act as a biosensor. On this basis, the structure can be produced for optical refractive index sensing in the biological, micro and nano fields. Full article
(This article belongs to the Special Issue Plasmonic Waveguide Biosensors)
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Article
Rapid and Highly Sensitive Detection of C-Reaction Protein Using Robust Self-Compensated Guided-Mode Resonance BioSensing System for Point-of-Care Applications
by
Chu-Tung Yeh
,
Devesh Barshilia
,
Chia-Jui Hsieh
,
Hsun-Yuan Li
,
Wen-Hsin Hsieh
and
Guo-En Chang
Biosensors 2021, 11(12), 523; https://doi.org/10.3390/bios11120523 - 20 Dec 2021
Cited by 5 | Viewed by 2352
Abstract
The rapid and sensitive detection of human C-reactive protein (CRP) in a point-of-care (POC) may be conducive to the early diagnosis of various diseases. Biosensors have emerged as a new technology for rapid and accurate detection of CRP for POC applications. Here, we [...] Read more.
The rapid and sensitive detection of human C-reactive protein (CRP) in a point-of-care (POC) may be conducive to the early diagnosis of various diseases. Biosensors have emerged as a new technology for rapid and accurate detection of CRP for POC applications. Here, we propose a rapid and highly stable guided-mode resonance (GMR) optofluidic biosensing system based on intensity detection with self-compensation, which substantially reduces the instability caused by environmental factors for a long detection time. In addition, a low-cost LED serving as the light source and a photodetector are used for intensity detection and real-time biosensing, and the system compactness facilitates POC applications. Self-compensation relies on a polarizing beam splitter to separate the transverse-magnetic-polarized light and transverse-electric-polarized light from the light source. The transverse-electric-polarized light is used as a background signal for compensating noise, while the transverse-magnetic-polarized light is used as the light source for the GMR biosensor. After compensation, noise is drastically reduced, and both the stability and performance of the system are enhanced over a long period. Refractive index experiments revealed a resolution improvement by 181% when using the proposed system with compensation. In addition, the system was successfully applied to CRP detection, and an outstanding limit of detection of 1.95 × 10−8 g/mL was achieved, validating the proposed measurement system for biochemical reaction detection. The proposed GMR biosensing sensing system can provide a low-cost, compact, rapid, sensitive, and highly stable solution for a variety of point-of-care applications. Full article
(This article belongs to the Special Issue Plasmonic Waveguide Biosensors)
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