Organs-on-a-Chip and Body-on-a-Chip Systems

Dear Colleagues, 

Organs-on-a-chip are engineered microfluidic systems that can maintain microphysiological tissues and recapitulate their functions and interactions. These platforms are often composed of a clear polymer that contain a network of channels with dimensions from tens to hundreds of micrometers, typically lined by endothelial cells to mimic vasculature, and tissue chambers to accommodate and create the physiologically relevant microenvironment of living organs via chemical and mechanical forces. These microsystems offer a great human-relevant alternative to conventional use of animals in drug testing. There has been great progress in developing and utilizing novel microfluidic platforms for various applications such as the kidney, bone marrow, intestine, skin, lung, and blood–brain barrier. However, organs-on-a-chip technology is still in the development phase and for its effective integration into the current pipeline of drug development, it is critical that it continues to get multidisciplinary contributions from studies focused on microfabrication techniques, novel biomaterials, stem cell differentiation, tissue engineering, and physiologically-based pharmacokinetic models (PBPK). Accordingly, this Special Issue seeks to showcase research papers, short communications, and review articles that focus on novel methodological developments in organs-on-a-chip and body-on-a-chip systems and contribute to the efforts in transforming their realistic use for various biomedical and clinical applications. The specific target areas for this Special Issue are as below:

Target areas:

• Novel materials and bioinks for engineering of human tissues and chip technologies (with an emphasis on the compatibility of materials and inks for being patterned via convenient technologies such as bioprinting at the resolution/scale of chambers used in organ-on-a-chips);
• Microphysiological human tissue engineering approaches for organs-on-a-chip systems;
• Development and integration of sensors, read-out methods, and microfabrication approaches for control and monitoring of organs-on-a-chip devices;
• End-point drug screening studies and approaches using organs-on-a-chip platforms.

Dr. Hasan Erbil Abaci
Dr. Savas Tasoglu
Guest Editors

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