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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Insights into the Role of Polyamines in Cellular Metabolism and Function

edited by

Cassandra E. Holbert

and

Tracy Murray Stewart

submission deadline 31 Dec 2025 | Viewed by 206 | Submission Open

Keywords: polyamine metabolism; putrescine; spermidine; spermine; polyamines in development; polyamines in health and disease; polyamines in cancer; polyamines in plant physiology

(This special issue belongs to the Section Cellular Biochemistry)

p53 Family: The Molecular Landscape in Cancer and Beyond

edited by

Paola Tucci

and Michele Pellegrino

submission deadline 31 Dec 2025 | Viewed by 186 | Submission Open

Keywords: p53 family; microRNA; tumorigenesis; aging; neurodegenerative diseases; immune regulation; biomarkers; therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Genetics and Molecular Breeding in Plants: Advances, Applications, and Future Directions

edited by Yurong Xie and Hongbin Wei

submission deadline 31 Dec 2025 | Viewed by 185 | Submission Open

Keywords: molecular genetics; molecular breeding; genome editing (CRISPR); omics technologies; stress resilience; trait discovery; genomic selection; sustainable agriculture; crop improvement; artificial intelligence in breeding

(This special issue belongs to the Section Molecular Genetics)

Lung Cancer: From Molecular Basis to Therapy

edited by

Paolo Borghetti

submission deadline 31 Dec 2025 | Viewed by 183 | Submission Open

Keywords: biomarkers; prognostic factors; predictive factors; genetic mutations and oncogenes; tumor suppressor genes; immune checkpoints and PD-L1; proteomic; genomic; radiomic

(This special issue belongs to the Section Molecular Biology)

Proteogenomics in Cancer Research

edited by

Chen Huang

submission deadline 31 Dec 2025 | Viewed by 183 | Submission Open

Keywords: bioinformatics; cancer research; proteogenomics; drug resistance; functional genomics

Design, Synthesis, and Therapeutic Applications of Heterocycles for Major and Neglected Diseases

edited by

Balraj Gopula

Tamal Kanti Das

and Arun Raja

submission deadline 31 Dec 2025 | Viewed by 146 | Submission Open

Keywords: heterocyclic compounds; medicinal chemistry; drug design; synthetic methodology; structure– activity relationship (SAR); major diseases; neglected tropical diseases; pharmacology

(This special issue belongs to the Section Chemical Biology)

Molecular Insights into Retinal Biology: Focus on Inflammation, Metabolism, and Retinal Dysfunction

edited by

, Qiuhua Yang,

and

submission deadline 31 Dec 2025 | Viewed by 142 | Submission Open

Keywords: inflammation; metabolism; neovascularization; retinal degeneration; photoreceptors; Muller glia; RPE

(This special issue belongs to the Section Molecular Medicine)

Antituberculous Drugs: Progress and Challenges

edited by

Ana Cristina Faria Ribeiro

and Ana Maria Telmo Dias Pereira Vicente Cabral

submission deadline 31 Dec 2025 | Viewed by 138 | Submission Open

Keywords: antituberculostatic drugs; carriers; bioavailability; delivery systems

(This special issue belongs to the Section Chemical Biology)

The Role of DNA Methylation, Histone Modifications and MicroRNA in Cancer

edited by

Joanna Szczepanek

submission deadline 31 Dec 2025 | Viewed by 138 | Submission Open

Keywords: epigenetic regulation; DNA methylation; histone modifications; microRNA; cancer progression; therapeutic resistance; tumor suppressor genes; oncogenic reprogramming; personalized cancer therapy; epigenetic therapy

(This special issue belongs to the Section Molecular Genetics)

Biomaterial Innovations for Tissue Engineering and Regeneration

edited by

Maria Chatzinikolaidou

submission deadline 31 Dec 2025 | Viewed by 137 | Submission Open

Keywords: biomaterials; tissue engineering; regenerative medicine; cellular responses; 3D pathophysiological tissue models

(This special issue belongs to the Section Bio-Engineered Materials)

Ocular Surface and Corneal Diseases: From Cellular and Molecular Biology to Therapeutic Strategies

edited by

Anat Galor

and Pragnya Rao Donthineni

submission deadline 31 Dec 2025 | Viewed by 132 | Submission Open

Keywords: dry eye disease; dry eye; aqueous tear deficiency; evaporative deficiency; ocular surface inflammation; tear osmolarity; epidemiology; limbal stem cell deficiency; neuropathic ocular pain; neurotrophic keratitis

(This special issue belongs to the Section Cellular Biochemistry)

Nutritional Intervention and Molecular Mechanism of Liver Cancer

edited by

Xian-Yang Qin

and Yohei Shirakami

submission deadline 31 Dec 2025 | Viewed by 112 | Submission Open

Keywords: liver cancer; nutrient signaling; inflammation and metabolism; cancer stem cells; precision nutrition

(This special issue belongs to the Section Molecular Medicine)

Embryo Implantation: New Molecular Insights in Endometrial Receptivity, Trophoblast Invasion and Signaling

edited by

Hans-Werner Denker

, Evdokia Dimitriadis and Lois A. Salamonsen

submission deadline 15 Jan 2026 | 8 articles | Viewed by 21475 | Submission Open

Keywords: embryo implantation; endometrial receptivity; trophoblast invasion; signaling

(This special issue belongs to the Section Molecular Reproduction)

Muscular Dystrophy: From Molecular Basis to Therapies: 2nd Edition

edited by

Francesca Sciandra

and

Kinga I. Gawlik

submission deadline 15 Jan 2026 | Viewed by 348 | Submission Open

Keywords: muscular dystrophies; muscle regeneration; extracellular matrix; satellite cells; therapeutic approaches; animal models; clinical trials

Molecular Pathology, Diagnostics and Therapeutics of Retinal Diseases: 2nd Edition

edited by

Antonio Ferreras

submission deadline 15 Jan 2026 | Viewed by 319 | Submission Open

Keywords: retina; macula; macular edema; inflammatory mediators; optical coherence tomography; retinal imaging; biochemical marker; biomarker; pharmacological targeting

Updates on Mitochondria and Cancer

edited by

Antonella Cormio

and

Clara Musicco

submission deadline 15 Jan 2026 | Viewed by 236 | Submission Open

Keywords: mitochondrial dysfunction in cancer; mitochondrial metabolomics; mitochondria and cancer therapy; mitochondria and cancer drug resistance; prognostic/predictive mitochondrial markers in cancer tissues and body fluids

(This special issue belongs to the Section Biological Factors)

Inflammation and Immunity in Lung Disease

edited by

Xuexian Yang

submission deadline 15 Jan 2026 | Viewed by 135 | Submission Open

Keywords: lung; infection; inflammation; host defense; cytokine release syndrome; genetic deficiency

(This special issue belongs to the Section Cellular Biochemistry)

Epigenetic Programming of Cellular States

edited by

Benjamin Carone

submission deadline 15 Jan 2026 | Viewed by 134 | Submission Open

Keywords: iPSCs; stem cells; reprogramming; chromatin; epigenetics

Skeletal Muscle Homeostasis and Regeneration: 2nd Edition

edited by

Ernő Zádor

submission deadline 15 Jan 2026 | Viewed by 94 | Submission Open

Keywords: skeletal muscle; homeostasis; regeneration; satellite cells; fiber type

(This special issue belongs to the Section Molecular Medicine)

Lipid Signaling in Neuroinflammation and Neurodegeneration

edited by

Jason R. Gerstner

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1488 | Submission Open

Keywords: lipid signaling; neuroinflammation; neurodegeneration; sphingolipids; eicosanoids; phospholipids; endocannabinoids; lipid mediators; molecular mechanisms; brain health

Novel Mechanisms in Renal Blood Pressure Regulation: From Neuropeptides to Angiotensin II and Dopamine Receptors

edited by

Hewang Lee

and

Pedro A. José

submission deadline 23 Jan 2026 | Viewed by 213 | Submission Open

Keywords: neuropeptides; dopamine; blood pressure; G protein-coupled receptors; oxidative stress kidney; vasculature; brain

Cellular Stress Responses in Oncogenesis and Metabolic Reprogramming

edited by

Kuo Hui Su

submission deadline 30 Jan 2026 | Viewed by 103 | Submission Open

Keywords: cellular stress response; metabolic reprogramming; oncogenesis; lipid metabolism; tumor adaptation; mitochondrial metabolism

(This special issue belongs to the Section Cellular Biochemistry)

Mitochondrial ROS in Health and Disease

edited by

Frank Krause

submission deadline 31 Jan 2026 | 8 articles | Viewed by 27425 | Submission Open

Keywords: aging; apoptosis; respiratory chain; redox signaling; paclitaxel

(This special issue belongs to the Section Chemical Biology)

Feature Papers in Cellular Biochemistry

edited by

Anna Rita Franco Migliaccio

submission deadline 31 Jan 2026 | 9 articles | Viewed by 22003 | Submission Open

Keywords: cell signalling; cell death; intracellular trafficking (protein; lipids; cytoskeleton; etc.); host– pathogen interactions; extracellular vesicle biology; intercellular communication; autophagy; cellular metabolism; inter-organelle communication; membrane transport; mitochondrial dynamics and function; cell polarity

(This special issue belongs to the Section Cellular Biochemistry)

Inositol Phosphates in Health and Disease, 2nd Edition

edited by

Ivana Vucenik

and

Abulkalam M. Shamsuddin

submission deadline 31 Jan 2026 | 7 articles | Viewed by 21835 | Submission Open

Keywords: inositol polyphosphates (IPs); IP6; inositol pyrophosphate (PP-Ips); signal transduction; energy metabolism; anticancer activity; PCOS; metabolic diseases; pathological calcification; neuropsychiatric disease

(This special issue belongs to the Section Molecular Medicine)

Mitochondrial Medicine: A Themed Issue in Honor of Prof. Dr. Carl A. Pinkert

edited by

Matthew McKenzie

submission deadline 31 Jan 2026 | 5 articles | Viewed by 21671 | Submission Open

Keywords: mitochondrial biology; mitochondrial disease; mitochondrial DNA; mitochondrial medicine; metabolism; therapeutics; oxidative phosphorylation; reactive oxygen species

(This special issue belongs to the Section Molecular Medicine)

Harnessing Protein Design and Engineering for Therapeutic Applications

edited by Julia Shifman and Norman Metanis

submission deadline 31 Jan 2026 | 5 articles | Viewed by 17630 | Submission Open

Keywords: therapeutic peptides and proteins; protein design and engineering; chemical protein synthesis; chemoselective protein modification; posttranslational protein modification

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

New Insights into Kidney Disease Development and Therapy Strategies

edited by

José I. López

and

Claudia Manini

submission deadline 31 Jan 2026 | 7 articles | Viewed by 16676 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

The Immune System and Allergies

edited by

Marco Casciaro

submission deadline 31 Jan 2026 | 4 articles | Viewed by 12121 | Submission Open

Keywords: immune system; allergy; inflammation; hypersensitivity; immunology

(This special issue belongs to the Section Cellular Biochemistry)

Advances in Metabolites Produced by Microbiota

edited by

Arancha Llama-Palacios

submission deadline 31 Jan 2026 | 3 articles | Viewed by 10178 | Submission Open

Keywords: microbiota; metabolites; short-chain fatty acids; amino acids; vitamins

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Mechanisms of Metabolic Regulation Used by G Protein-Coupled Receptors

edited by

Hongxia Ren

and Jason M. Conley

submission deadline 31 Jan 2026 | 4 articles | Viewed by 9728 | Submission Open

Keywords: diabetes; obesity; metabolism; GPCR; signaling

(This special issue belongs to the Section Molecular Biology)

The Illumination of Biophysical Mechanisms by Hydrogen Exchange: A Themed Issue in Honor of Professor S. Walter Englander

edited by

A. Joshua Wand

submission deadline 31 Jan 2026 | 4 articles | Viewed by 8036 | Submission Open

Keywords: hydrogen exchange chemistry; HX– NMR; HX-MS; protein folding; allostery; protein binding; protein thermodynamics; protein biophysics; protein function

(This special issue belongs to the Section Molecular Biology)

Digestive Enzymes in Health and Disease

edited by Stefan G. Pierzynowski, Kateryna Pierzynowska,

Piotr Wychowański

and

Janine Donaldson

submission deadline 31 Jan 2026 | 5 articles | Viewed by 7729 | Submission Open

Keywords: digestive enzymes; gastrointestinal health; enzyme replacement therapy; gut microbiome; metabolic disorders; enzyme regulation; disease biomarkers; inflammatory diseases; nutrient absorption; therapeutic enzymes

(This special issue belongs to the Section Enzymology)

Cellular and Molecular Mechanisms in Cardiopathy and Therapeutic Strategies

edited by Ying-Hsi Lin and Shengjie Lu

submission deadline 31 Jan 2026 | 8 articles | Viewed by 7479 | Submission Open

Keywords: heart failure; cardiac remodelling; contractile dysfunction; bioenergetics; gene replacement or editing

(This special issue belongs to the Section Molecular Medicine)

Retinal Diseases: Molecular Mechanisms and Therapies

edited by

Ana Raquel Santiago

and Raquel Boia

submission deadline 31 Jan 2026 | 3 articles | Viewed by 7262 | Submission Open

Keywords: retinal diseases; molecular mechanisms; therapeutic strategies; vision impairment; gene therapy; retinal degeneration; neuroprotection; innovative treatments

(This special issue belongs to the Section Cellular Biochemistry)

Advanced Biomaterials for Healing Oral Tissues

edited by Miki Taketomi Saito and

Rafael R. Lima

submission deadline 31 Jan 2026 | 1 articles | Viewed by 6809 | Submission Open

Keywords: biocompatible materials; biopolymers; dental implants; materials testing; pharmaceutical preparations; regeneration; regenerative medicine; tissue scaffolds; wound healing

(This special issue belongs to the Section Bio-Engineered Materials)

Pharmacology of Cardiovascular Diseases

edited by

Istvan Lekli

, Alexandra Gyongyosi and

Istvan Bak

submission deadline 31 Jan 2026 | 3 articles | Viewed by 6649 | Submission Open

Keywords: cardioprotection autophagy; redox balance; heart faliure; cardiovascular pharmacotherapy

(This special issue belongs to the Section Molecular Medicine)

Neurodevelopmental Disorders: Genetic Studies and Therapeutic Strategies

edited by

Susanna Pietropaolo

and Bruno Bontempi

submission deadline 31 Jan 2026 | 2 articles | Viewed by 4714 | Submission Open

Keywords: mouse models; Autism Spectrum disorder; transgenic rodents; pharmacological treatments; gene-environment interactions; neurodevelopmental disorders; rare diseases

(This special issue belongs to the Section Molecular Genetics)

Molecular Advances in Rett Syndrome and Other Chromatin Related Disorders

edited by

Floriana Della Ragione

and Salvatore Fioriniello

submission deadline 31 Jan 2026 | 2 articles | Viewed by 4692 | Submission Open

Keywords: Rett syndrome and other chromatin disorders; epigenetic diseases; molecular alterations in Rett syndrome and other chromatin diseases; novel genes associated with chromatin disorders; MeCP2-mediated molecular mechanisms; roles of epigenetic modulators in chromatin-related diseases; preclinical studies for chromatin diseases; novel diagnostic; prognostic and therapeutic approaches for chromatin disorders

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Novel Treatments of Stroke

edited by

Saif Ahmad

and Naseem Akhter

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3492 | Submission Open

Keywords: ischemic stroke; molecular mechanisms; neuroinflammation; signaling pathways; therapeutic approaches

(This special issue belongs to the Section Molecular Biology)

Pluripotent Stem Cells: From Basic Research to Therapeutic Applications

edited by

Claudia Spits

and

Diana Al Delbany

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2812 | Submission Open

Keywords: pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells; organoids; differentiation; regenerative medicine; disease modeling; cell therapy; therapeutic applications

(This special issue belongs to the Section Molecular Biology)

Natural Products and Their Derivatives with Antiviral Activity

edited by

Zhijun Zhang

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2795 | Submission Open

Keywords: natural products; synthetic antivirals; antiviral drugs; antiviral strategies; influenza; HBV; HIV; RSV; COVID-19; SARS-CoV-2

(This special issue belongs to the Section Natural and Bio-derived Molecules)

New Insights into Mechanisms and Therapeutics for Cardiovascular Disorders: 2nd Edition

edited by

Carola Yvette Förster

Mohsin Saleet Jafri

and Tarun W. Dasari

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2312 | Submission Open

Keywords: brain– heart axis; heart and stroke; stress-induced cardiomyopathy; cardiovascular disease

(This special issue belongs to the Section Molecular Medicine)

Advances and Novel Strategies for Studying Underexplored Post-Translational Modifications (PTMs)

edited by

Yue Chen

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2267 | Submission Open

Keywords: post-translational modifications proteomics; chemical biology; cell signaling; epigenetics; metabolic regulation; cancer; diabetes; microbiome; aging

(This special issue belongs to the Section Molecular Biology)

Key Molecules Regulating Plant Response to Abiotic Stress: Transcription Factors and Stress-Induced Proteins

edited by

Fei Gao

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1790 | Submission Open

Keywords: abiotic stress response; transcription factors; stress-induced proteins; molecular mechanisms; transcriptomics; omics; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Current Advances of Metal Complexes for Biomedical Applications

edited by

Marcelino Maneiro

and

Sandra Fernández-Fariña

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1721 | Submission Open

Keywords: metal complexes; metals in medicine; bioinorganic; anti-cancer; antiviral; anti-inflammatory; antioxidant; imaging applications

(This special issue belongs to the Section Chemical Biology)

Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants: 2nd Edition

edited by

Daniela Grimm

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1488 | Submission Open

Keywords: cells; humans; animals; plants; microorganisms; microgravity; weightlessness; cancer research; tissue engineering; space-related health problems

(This special issue belongs to the Section Cellular Biochemistry)

State-of-the-Art Protein X-Ray Crystallography

edited by Wu-Pei Su and

Hongxing He

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1376 | Submission Open

Keywords: ab initio phasing methods; X-ray crystallography; protein structural determination; image reconstruction from Fourier amplitudes; iterative projection algorithms; phasing with deep learning methods

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Developmental Biology of the Kidney: From Molecular Mechanisms to Congenital Disorders

edited by

Katarina Vukojević

and Anita Racetin

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1263 | Submission Open

Keywords: kidney development; renal physiology; kidney disease; molecular mechanisms; cellular signaling; gene expression; biomarkers; renal pathophysiology; therapeutic targets

(This special issue belongs to the Section Molecular Medicine)

Lung Disease: From Molecular Mechanism to Therapeutic Opportunities

edited by

Patrick G. Arndt

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1093 | Submission Open

Keywords: biomarkers; pharmacotherapeutics; cell signaling; innate immunity; inflammation

(This special issue belongs to the Section Molecular Biology)

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