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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cysteine and Selenocysteine in Antioxidant Defense, Protein Synthesis and Signaling Pathways

edited by

Maria Wrobel

and

Halina Jurkowska

submission deadline 15 Dec 2025 | 3 articles | Viewed by 5276 | Submission Open

Keywords: cysteine; selenocysteine; taurine; hydrogen sulfide; hydrogen selenide; selenoproteins; sulfurtransferases; H2S precursors; antioxidants; diseases related to sulfur metabolism

(This special issue belongs to the Section Molecular Biology)

Role of TRAF in Regulating Inflammation and Cell Survival

edited by Ali Abdul-Sater

submission deadline 15 Dec 2025 | 2 articles | Viewed by 5075 | Submission Open

Keywords: TRAF; inflammation; inflammasome; TNFRs; apoptosis; cellular survival

(This special issue belongs to the Section Biological Factors)

New Insights into Cardiovascular Immunology

edited by Susanne Sattler, Pilar Martín and Stephen Malin

submission deadline 15 Dec 2025 | 1 articles | Viewed by 4539 | Submission Open

Keywords: inflammation; autoimmunity; atherosclerosis; myocarditis; heart failure

(This special issue belongs to the Section Molecular Medicine)

Epstein-Barr Virus Disease Mechanisms and Stress Responses: 2nd Edition

edited by

Marshall Vance Williams

submission deadline 15 Dec 2025 | Viewed by 602 | Submission Open

Keywords: Epstein– Barr virus (EBV); reactivation; immune modulation; stress; aging

(This special issue belongs to the Section Molecular Medicine)

Novel Insights on Cancer Stem Cells

edited by

Veronica Veschi

submission deadline 15 Dec 2025 | Viewed by 512 | Submission Open

Keywords: cancer stem cells; cancer initiating cells; stemness; self-renewal; therapy resistance; epigenetic reprogramming

(This special issue belongs to the Section Molecular Medicine)

Nanomaterials and Smart Delivery Systems in Combating Drug-Resistant Infections

edited by Hanif Haidari and

Zlatko Kopecki

submission deadline 15 Dec 2025 | Viewed by 245 | Submission Open

Keywords: nanomaterials; antimicrobial biomolecules; tissue engineering; metallic nanoparticles; smart hydrogels; drug-resistant infections; controlled drug delivery; biomaterial-tissue interactions

(This special issue belongs to the Section Bio-Engineered Materials)

Novel Materials for Biomedical Applications: 3rd Edition

edited by

Jayakumar Rajadas

and

Mustafeez Mujtaba Babar

submission deadline 15 Dec 2025 | Viewed by 93 | Submission Open

Keywords: micro-/nanocarriers; synthesis or conjugation of biomaterials; drug delivery; targeted therapy/immunotherapy for combinatorial treatment; regenerative medicine/tissue engineering

(This special issue belongs to the Section Bio-Engineered Materials)

Metabolism and Milk Quality in Dairy Cows: Dietary Influences and Transcriptomic Insights

edited by

Massimo Bionaz

submission deadline 20 Dec 2025 | Viewed by 193 | Submission Open

Keywords: dairy cows; transcriptomics; milk quality; nutrigenomics; epigenomics; diet; ration; transition period; lactation; dry period

Inflammatory Pathways in Heart Failure

edited by

Pietro Scicchitano

submission deadline 30 Dec 2025 | Viewed by 130 | Submission Open

Keywords: inflammation; heart failure; molecular mechanism; heart failure therapies

(This special issue belongs to the Section Molecular Medicine)

Feature Papers in the Natural and Bio-Derived Molecules Section

edited by

Hang Fai (Henry) Kwok

submission deadline 31 Dec 2025 | 9 articles | Viewed by 51660 | Submission Open

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Advances in Mechanism and Regulation of Lifespan and Aging

edited by Mark McCormick

submission deadline 31 Dec 2025 | 7 articles | Viewed by 36546 | Submission Open

Keywords: aging; lifespan; healthspan

(This special issue belongs to the Section Molecular Biology)

Biochemistry in Medicine—Honorary Special Issue Commemorating Research and Work of Professors Jan O. Aaseth and Jan Alexander

edited by Sonia Distante and

Per M. Roos

submission deadline 31 Dec 2025 | 5 articles | Viewed by 35046 | Submission Open

Keywords: medical biochemistry; endocrinology; neurotoxic metals

(This special issue belongs to the Section Molecular Medicine)

Insights from the Editorial Board Members

edited by

Peter E. Nielsen

submission deadline 31 Dec 2025 | 11 articles | Viewed by 25148 | Submission Open

Keywords: structure and function; bioactive and biogenic substances; molecular mechanisms; biomaterials

Tissue Calcification in Normal and Pathological Environments

edited by

Fulvia Ortolani

submission deadline 31 Dec 2025 | 9 articles | Viewed by 24804 | Submission Open

Keywords: calcification; ectopic mineralization; bone; heterotopic ossification; calcium phosphate; calcium carbonate; calcium oxalate; procalcific cell death

(This special issue belongs to the Section Molecular Medicine)

Cellular and Molecular Mechanism of Spermatogenesis

edited by YanHe Lue

submission deadline 31 Dec 2025 | 4 articles | Viewed by 20618 | Submission Open

Keywords: spermatogenesis; regulation; biomolecules

(This special issue belongs to the Section Molecular Reproduction)

Cardiometabolic Disease: Molecular Basis and Therapeutic Approaches

edited by

Nikolaos Theodorakis

and Maria Nikolaou

submission deadline 31 Dec 2025 | 4 articles | Viewed by 19884 | Submission Open

Keywords: cardiometabolic medicine; preventive cardiology; cardiovascular endocrinology and metabolism; obesity; diabetes mellitus; cardiovascular disease

(This special issue belongs to the Section Molecular Medicine)

Neuroimmune Interactions in Neuropsychiatric Diseases

edited by

Luciana Frick

submission deadline 31 Dec 2025 | 4 articles | Viewed by 19050 | Submission Open

Keywords: neurology; psychiatry; immunity; glia

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms in DNA and RNA Damage and Repair

edited by

Marino J. E. Resendiz

Chryssostomos Chatgilialoglu

and

Yuan Liu

submission deadline 31 Dec 2025 | 8 articles | Viewed by 17875 | Submission Open

Keywords: reactive oxygen species; DNA damage; DNA repair; RNA damage; RNA repair; molecular mechanisms; biomarkers; antioxidant and redox strategies; oxidative stress

(This special issue belongs to the Section Molecular Biomarkers)

Cell Biology and Biomedical Application of Galectins

edited by

Alexander Timoshenko

submission deadline 31 Dec 2025 | 6 articles | Viewed by 15761 | Submission Open

Keywords: galectins; cell differentiation; stem cells; apoptosis; autophagy; cell adhesion; glycobiology; post-translational modifications; transmembrane signaling; protein trafficking; cancer; heart diseases; fibrosis; inflammation; targeted therapeutics; galectin inhibitors

(This special issue belongs to the Section Chemical Biology)

Natural Bioactives as Leading Molecules for Drug Development

edited by

Chang Liu

Hang Ma

and

Ang Cai

submission deadline 31 Dec 2025 | 7 articles | Viewed by 14985 | Submission Open

Keywords: drug discovery; natural products; leading molecules; isolation and identification; phytochemical investigation; omics approaches

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Melatonin in Normal Physiology and Disease, 2nd Edition

edited by

Georges Maestroni

submission deadline 31 Dec 2025 | 4 articles | Viewed by 14769 | Submission Open

Keywords: circadian rhythms; immunity; skin; reproduction; aging; viral and bacterial infection; inflammation; mesenchymal stem cells; cancer; neurodegenerative diseases; osteoporosis

(This special issue belongs to the Section Molecular Biology)

New Insight into the Molecular Genetics of Neurodevelopmental Disorders

edited by

Luciana Musante

and Flavio Faletra

submission deadline 31 Dec 2025 | 5 articles | Viewed by 14013 | Submission Open

Keywords: neurodevelopmental disorders; next generation sequencing; pathomechanisms; phenotypic spectra; phenotype-genotype correlation

(This special issue belongs to the Section Molecular Genetics)

Genetic and Structural Analyses of Coronaviruses: Insights into SARS-CoV-2 and Beyond

edited by

Stefano Pascarella

submission deadline 31 Dec 2025 | 8 articles | Viewed by 13878 | Submission Open

Keywords: SARS-CoV-2 variants; protein variants; protein structure; virus evolution; mutations; structural bioinformatics; molecular phylogenesis; host– pathogen molecular interactions; molecular immunology; drug discovery

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Molecular and Toxicological Profiling of Drugs of Abuse—in Honor of Professor Félix Carvalho

edited by

João Pedro Silva

and

Vera Marisa Costa

submission deadline 31 Dec 2025 | 3 articles | Viewed by 13450 | Submission Open

Keywords: toxicodynamic; toxicokinetic; amphetamine-type stimulants; cannabis and cannabinoids; cocaine; hallucinogens; new psychoactive substances; opioids; immune modulation

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Sex and Evolution

edited by

Ikuo Miura

and

Michihiko Ito

submission deadline 31 Dec 2025 | 5 articles | Viewed by 12603 | Submission Open

Keywords: sex determination; sex chromosome evolution; reproduction; hybridization; speciation; evolution; animals; vertebrates

(This special issue belongs to the Section Molecular Genetics)

Mitochondrial Proteins: From Import and Biogenesis to Complex Functional Network

edited by

Venkatesh Sundararajan

submission deadline 31 Dec 2025 | 4 articles | Viewed by 12100 | Submission Open

Keywords: mitochondrial proteins; import; biogenesis; metabolism; functional network; oxidative stress; small molecules; mitochondrial protein quality control; mitophagy

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Integrating Genetics, Immune Dysregulation, and the Gut Microbiome: Advances in Elucidating IBD Pathophysiology and Emerging Therapeutic Strategies

edited by

Peter W. Jurutka

and

Todd R. Sandrin

submission deadline 31 Dec 2025 | 3 articles | Viewed by 11427 | Submission Open

Keywords: microbiome; biomarkers; Crohn’ s disease; ulcerative colitis; indeterminate colitis; multiomics; gastrointestinal (GI disease); immunology; gut– brain axis; neuropsychology

(This special issue belongs to the Section Molecular Genetics)

Innate Immunomodulation and Inflammation: From Molecular Mechanisms to Pre-Clinical Insights

edited by

Fabián Flores-Borja

Shunbin Ning

and

Michael Torzewski

submission deadline 31 Dec 2025 | 4 articles | Viewed by 10976 | Submission Open

Keywords: innate immunity; therapy; immune checkpoints; cancer; autoimmunity; inflammation; infection; danger-associated molecular patterns; pattern recognition receptors

(This special issue belongs to the Section Molecular Medicine)

Human Reproductive Biology: Uncertainties and Controversies

edited by

Giuseppe Benagiano

Marwan Habiba

and Paola Bianchi

submission deadline 31 Dec 2025 | 5 articles | Viewed by 10872 | Submission Open

Keywords: molecular reproduction; endometriosis; endometrium; implantation; decidualization; placenta; cellular senescence; prostaglandin; inflammation; pregnancy; reproduction; implantation; decidualization; endometriosis; assisted reproductive technology; molecular reproductive biology; reproductive biology; reproductive immunology; reproductive medicine; reproductive endocrinology; molecular regulation of reproductive processes; embryo development; reproductive biology; gametogenesis and fertilization

(This special issue belongs to the Section Molecular Reproduction)

Biosynthesis and Function of Thyroid Hormones

edited by

Josef Koehrle

and Eva K. Wirth

submission deadline 31 Dec 2025 | 4 articles | Viewed by 10840 | Submission Open

Keywords: thyroid gland; thyroid follicle; TH release; iodide; deiodinase; TH transmembrane transport; TH receptors; intracellular TH binding proteins; thyroglobulin; sodium– iodide symporter; thyroperoxidase; dual oxidase; thyroid-relevant trace elements

(This special issue belongs to the Section Biological Factors)

Molecular Diagnosis and Regulation of Mitochondrial Dysfunction

edited by

Cecilia Giulivi

submission deadline 31 Dec 2025 | 3 articles | Viewed by 10806 | Submission Open

Keywords: metabolic conditions; neurological conditions; genetic diseases; mitochondrial dysfunction; mitochondrial disorders; diagnostics; therapies

(This special issue belongs to the Section Biological Factors)

Molecular Mechanisms of Cardiovascular Remodeling

edited by

Mingyi Wang

submission deadline 31 Dec 2025 | 3 articles | Viewed by 10755 | Submission Open

Keywords: vascular remodeling aging; extracellular matrix; atherosclerosis peripheral; artery disease; chronic heart failure; cardiovascular associated cognitive decline

(This special issue belongs to the Section Molecular Biology)

Antitumor Agents from Natural Sources 2024–2025

edited by

Hang Fai (Henry) Kwok

submission deadline 31 Dec 2025 | 2 articles | Viewed by 10135 | Submission Open

Keywords: antitumor agents; natural sources; cancer prevention and therapy

(This special issue belongs to the Section Natural and Bio-derived Molecules)

The Role of Non-Coding RNAs in Health and Disease

edited by

Narasimman Gurusamy

submission deadline 31 Dec 2025 | 6 articles | Viewed by 9749 | Submission Open

Keywords: non-coding RNA; microRNA (miRNA); long noncoding RNA (lncRNA); circular RNA (circRNA); gene expression regulation; epigenetic modifications

(This special issue belongs to the Section Molecular Genetics)

Advances in Melanoma Targeted Therapy

edited by

Dmitriy Minond

submission deadline 31 Dec 2025 | 3 articles | Viewed by 9420 | Submission Open

Keywords: melanoma; drug discovery; new targets; target discovery

(This special issue belongs to the Section Molecular Medicine)

Signal Transduction to Transcription Factors in Health and Disease—Honorary Special Issue Commemorating the Work of Prof. Athanasios G. Papavassiliou

edited by

Christina Piperi

and

George D. Kalliolias

submission deadline 31 Dec 2025 | 4 articles | Viewed by 8139 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

The Role of Nanoparticles in Tumor Treatment

edited by

Carla Vitorino

submission deadline 31 Dec 2025 | 2 articles | Viewed by 8005 | Submission Open

Keywords: nanoparticles; cancer therapy; nanotechnology

(This special issue belongs to the Section Chemical Biology)

Matrix Metalloproteinases: Mechanisms, Functions and Therapeutic Potential

edited by

Alireza Shoari

, Joshua W. Ogony and

Gokara Mahesh

submission deadline 31 Dec 2025 | 2 articles | Viewed by 7977 | Submission Open

Keywords: matrix metalloproteinases; endopeptidases; MMP inhibitor; tissue homeostasis; disease progression

(This special issue belongs to the Section Enzymology)

Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges

edited by

Atsushi Saito

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7270 | Submission Open

Keywords: periodontal disease; periodontitis; periodontal regeneration; periodontal tissue engineering; biological agents; biomaterials

(This special issue belongs to the Section Bio-Engineered Materials)

Cellular Signaling in Cancer

edited by

Avisek Majumder

, Shabana Bano and Kasturi Nayak

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6859 | Submission Open

Keywords: signaling pathways; cancer; anti-cancer

(This special issue belongs to the Section Cellular Biochemistry)

Computational Intelligence in Structure and Function Prediction and Modeling of Proteins—2nd Edition

edited by

Jian Zhang

Bi Zhao

and Haiting Chai

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6597 | Submission Open

Keywords: protein tertiary structure; protein folding; protein functions; intrinsic disorder; drug discovery; protein– drug interaction; computational intelligent algorithms; artificial intelligence for proteomics; high-throughput proteomics

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

New Insights into Molecular Mechanisms and Therapeutics for Malaria

edited by

Maria Isabel Veiga

submission deadline 31 Dec 2025 | 2 articles | Viewed by 6574 | Submission Open

Keywords: antimalarial resistance; drug discovery; malaria epidemiology; diagnostic tools; malaria pathophysiology

(This special issue belongs to the Section Molecular Medicine)

Cellular and Molecular Biology of Neurodevelopment

edited by

David M. Feliciano

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6447 | Submission Open

Keywords: neural stem cells; neuroblasts; neurons; glia; microglia; molecular pathways; genes; mutations; pharmacology; toxicology; neurodevelopment; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Biology)

Barrier Formation and Homeostasis in the Vertebrate Brain

edited by

Ramani Ramchandran

Karthikeyan Thirugnanam

and

Ankan Gupta

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6040 | Submission Open

Keywords: brain endothelial cell; pericytes; choroid plexus; retina; lymphatic; blood; astrocytes; oligodendrocytes; brain ventricle; microglia

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Biomarkers in Cardiology 2025

edited by

Pietro Scicchitano

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6029 | Submission Open

Keywords: cardiovascular diseases; cardiovascular pathology and histology; carotid plaques and histology; endothelium and endothelial dysfunction; veins diseases; arrhythmias; heart

(This special issue belongs to the Section Molecular Biomarkers)

Recent Advances in the Enzymatic Synthesis of Bioactive Compounds

edited by

Bartłomiej Zieniuk

submission deadline 31 Dec 2025 | 5 articles | Viewed by 5993 | Submission Open

Keywords: biocatalysis; biotransformation; enzyme-catalyzed reactions; whole-cell catalysis; green chemistry; enzymes; phenolic compounds; polyphenols; lipases; lipophilization; enzymatic synthesis; esterification; transesterification; green and sustainable chemistry approaches; lipid modification

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Chemical Biology and Biotechnology of Nucleosides, Nucleotides, and Nucleic Acids

edited by

Xingguo Liang

and

Xinjing Tang

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5906 | Submission Open

Keywords: nucleosides; nucleotides; nanostructure; circular ssDNA; circular RNA; quadruplex; conjugate; lncRNA; DNAzyme; ribozyme

(This special issue belongs to the Section Chemical Biology)

Antimicrobial Peptides in Nature: Inspiration for Rationally Designed Antimicrobials

edited by

Mire Zloh

and

Rachael Dickman

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5648 | Submission Open

Keywords: antimicrobial resistance; antimicrobial peptides; rational design of peptides; antimicrobial peptide synthesis; peptidomimetic antimicrobial agents

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Gametogenesis and Gamete Interaction, 2nd Edition

edited by

Hitoshi Sawada

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5305 | Submission Open

Keywords: gametogenesis and meiosis; sperm attraction and activation; gamete interaction and recognition; species specificity and self/nonself-recognition in hermaphrodites; acrosome reaction sperm penetration of egg coat; gamete membrane fusion; polyspermy block; egg activation

(This special issue belongs to the Section Molecular Reproduction)

Signaling Pathways as Therapeutic Targets for Cancer

edited by Fabian Benencia

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5252 | Submission Open

Keywords: cancer signaling pathways; cancer metabolism; small molecules; anticancer antibodies; tumor models; combinatorial therapies

(This special issue belongs to the Section Molecular Biology)

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