Special Issue "Natural Bioactives as Leading Molecules for Drug Development"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-inspired Molecules".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 45

Special Issue Editor

Special Issue Information

Dear Colleagues,

Natural products have been used since ancient times, and are now used in traditional medicine and modern-day therapies as drugs or drug templates. Nature is a rich source of chemical diversity, which leads to broad diversity in the mechanisms of biological action and drug-like properties of natural products. Moreover, nature provides countless active ingredients, with new potentially bioactive molecules from natural resources reported every day. Identifying bioactive compounds is the initial step in drug discovery, and there has been increasing interest in the derivatization of natural metabolites. Computer-aided design and in silico approaches are also considered promising tools in the discovery of new derivatives from natural products.

This Special Issue aims to collect original and/or review papers that contribute to natural product chemistry research. We invite researchers to contribute papers on the chemistry of naturally occurring compounds, with a focus on the isolation, structure elucidation, and chemical synthesis of novel compounds, and in silico studies. We also welcome evaluations of the biological activities of novel compounds, their structure–activity relationship, and their molecular mechanisms of action, and are particularly interested in new works in related fields.

Dr. Patrícia Rijo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • natural product chemistry
  • natural product biological activity
  • extraction, isolation, and structural characterization
  • natural product synthesis and semi-synthesis
  • natural product molecular docking

Published Papers

This special issue is now open for submission.
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