Special Issue "Advanced Immunology of Oligodendrocyte Progenitor Cells"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (1 March 2023) | Viewed by 108

Special Issue Editor

Department of Pathology, University of Iowa, Iowa City, IA 52242, USA
Interests: neuroimmunology; multiple Sclerosis; OPCs; mucosal Immunology; gut-brain axis

Special Issue Information

Dear Colleagues,

Oligodendrocyte progenitor cells (OPCs) derive from neural stem cells during embryonic development and are present throughout the central nervous system (CNS). OPCs account for appropriately 5–8% of brain cells. For quite a long period, the most extensively studied function of OPCs has been their differentiation and maturation into mature oligodendrocytes. This view has largely expanded in the last decade. We now know that OPCs participate in angiogenesis, form synapses with neurons, and provide energy to neurons as well. Of note, emerging studies have demonstrated OPCs as resident non-immune cells with various immune functions. Firstly, OPCs respond to numerous immune stimuli, including interferons, interleukins and TNFα. Secondly, OPCs produce cytokines and chemokines that modulate regional immunity in the CNS. Thirdly, OPCs function as antigen-presenting cells in certain contexts, thus manipulating adaptive immunity. Even though our understating of the immune function of OPCs is in its infancy, many questions remain unanswered or to be clarified. For example:

  • How do immune factors contribute to the homeostasis of OPCs?
  • How does inflammation affect the fate and function of OPCs in neurodegenerative diseases?
  • How do OPCs modulate CNS regional immunity in health and disease? 

This Special Issue titled “Advanced Immunology of Oligodendrocyte Progenitor Cells” aims to provide a platform for colleagues in this field to showcase their research progress in related topics. We believe research on the interplay between OPCs and the immune system will open new avenues for therapeutic strategies in neurological disorders.

Dr. Zizhen Kang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • oligodendrocyte progenitor cells
  • immune modulation
  • neurodegenerative disease

Published Papers

There is no accepted submissions to this special issue at this moment.
Back to TopTop