Dear Colleagues,

Skeletal muscle is the largest tissue in mammals, contributing  about 40% of their total body mass. This entity shows remarkable variation and is exposed to numerous environmental constraints and pathological conditions. How does the skeletal muscle face these challenges? What algorithms maintain integrity after trial runs or detrimental conditions? The answers have been sought for several decades, first in vitro and, later, in combined studies. As a result, skeletal muscle became a favorite object of differentiation molecular biology. It has inseminated the field of heart muscle adaptation and helped to form a more realistic view of heart regeneration. Skeletal muscle regeneration is well suited for differential gene expression studies. First the transcription factors and later the signal pathways were sought out with remarkable success; the revealed complexity explained a lot about phenotypical variations. The pivotal roles of non-muscle components such as extracellular tissue and inflammatory and angiogenic cells have been found in addition to the nerves’ influence.

In this planned Special Issue, we welcome any submissions on the topic of molecular biology of skeletal muscle regeneration and adaptation. Since this topic belongs to the field of differentiation, studies that investigate morphology and phenotype with molecular changes are especially welcome. Approaches focusing primarily on the molecular biology of non-muscle cells in skeletal muscle regeneration and adaptation are also encouraged. Both reviews and original contributions will be considered.

Prof. Dr. Ernő Zádor 
Guest Editor

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• skeletal muscle
• regeneration
• adaptation