Special Issue "Non-classical Signaling of Steroid Hormones and Their Specific Receptors: Physiological and Pathophysiological Implications"
Deadline for manuscript submissions: 31 July 2022 | Viewed by 171
Interests: biomembranes and bioenergetics; heterologous expression of mammalian proteins; steroid hormones; cell signaling; membrane-bound steroid receptors
Since the 1980s and 1990s, when several steroid hormone receptors (SHRs) were cloned, the central dogma for steroid hormone action has been that steroid hormones signal exclusively through cellular cytosolic/nuclear receptors. These SHRs are basically ligand-activated transcription factors. When activated by their specific steroid hormone, they dimerize and translocate from the cytosol into the nucleus. Once there they elicit changes in gene expression; thus, the cellular responses to steroid hormone actions are referred to as genomic effects.
This dogma, however, was put into question by the results of following investigations, demonstrating a transcription-independent signaling pathway of the steroid hormone progesterone, which inhibited within minutes two functional effects of oxytocin signaling by binding to the oxytocin receptor from the family of G-protein-coupled receptors (GPCR): the production of the second messenger inositol 1,4,5-trisphosphate and an increase in the concentration of intracellular Ca2+.
Meanwhile, a vast amount of scientific studies demonstrated that several steroid hormones interact not only with cytosolic/nuclear SHRs but also with membrane SHRs (mSHRs), which induce rapid signaling events. These signaling events are termed non-classical in order to distinguish them from events generated through the interaction of steroid hormones with nuclear SHRs, which are now referred to as classical.
Although a series of mSHRs for various steroid hormones has been identified thus far, the general perception for steroid hormone actions has not changed despite new knowledge. The classical cytosolic/nuclear SHRs are still perceived and presented as the main mediators of steroid hormone actions, and the membrane-mediated steroid hormone signaling events are either seen as supplementary to their classical signaling pathways or are entirely ignored. Considering the large number of recent publications demonstrating not only the specific interactions of certain steroid hormones with their corresponding mSHRs but also their physiological and pathophysiological relevance, including various cancers, I feel that it is time to terminate the “stepmotherly” treatment of the new class of mSHRs by summarizing and documenting their importance in a comprehensive reference study.
Rapid non-classical actions of steroid hormones that originate at membrane receptors are of great physiological and also pathophysiological importance. Several original and review articles have documented their importance; nevertheless, a comprehensive reference work that includes current knowledge dealing with these aspects is missing. For these reasons, I would like to invite specialists, whose research focuses on the actions of a specific steroid hormone and its corresponding membrane receptor, to share their expertise within the framework of the Special Issue mentioned above.
Although authors have their own writing styles, in order to have some consistency among the various articles, I would like to ask the contributors to cover the following topics in their manuscripts:
- Classical actions of the respective SH. Firm background information concerning original knowledge about the interactions of SH with its cytosolic/nuclear SHR;
- Non-classical actions of the respective SH.
2.1. The membrane steroid hormone receptor(s) (mSHR) of the respective SH (classification and biochemical characterization of the receptor);
2.2. Signaling cascades generated by the interactions of the respective SH with its mSHR (mediation and propagation of SH/mSHR interactions into the cell);
- Importance of these interactions in health and disease (physiological and pathophysiological significance of SH/mSHR interactions);
- The mSHR as pharmacological target (agonists and antagonists of the SH/mSHR interactions and perspectives for their therapeutic applications).
By integrating present knowledge about rapid actions of SH through their specific mSHRs in the envisioned Special Issue, we will not only provide a comprehensive reference work for professionals and students but we also hope to stimulate future investigations aiming to unveil, thus far, unidentified actions of SH, to understand their physiological and pathophysiological effects, and to address their potential as pharmacological targets in clinical applications.
Prof. Dr. Georgios Scheiner-Bobis
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- steroid hormone
- steroid hormone receptors