Pulmonary Hypertension-Induced Changes from the Right Heart to Lung Blood Vessels and Beyond

Dear colleagues,

Pulmonary hypertension is a chronic pulmonary disease with various pathophysiological aetiologies, which share the common feature of elevated pulmonary arterial pressures. In recent decades, remarkable progress in terms of knowledge related to and in treating this disease through rigorous research has been accomplished. Since the introduction of the new hemodynamic definition of pulmonary hypertension, the in-depth description of load-independent right ventricular function and the growing awareness of the molecular foundation of vascular remodelling represent a major step forward in the comprehensive understanding of the pulmonary circulation. Nevertheless, research and knowledge gaps remain, especially in addressing the impact of the novel diagnostic pulmonary pressure thresholds starting from in vitro to pre-clinical models and finally with a transition to daily clinical practice. Moreover, in light of the COVID-19 pandemic, the impact of the virus and/or inflammation on the pulmonary circulation, the right heart and vessels is a matter of ongoing research and debate. This Special Issue invites original research papers and reviews that cover all aspects of the field of pulmonary hypertension, from cell to animal models, clinical research, observational studies and registry data exploring right ventricular to pulmonary arterial interactions and beyond the pulmonary vasculature. These will take under consideration inflammation, COVID-19, hemodynamics, exercise and advanced state-of-the-art imaging while applying the current recommendations of the 2018 World Conference of Pulmonary Hypertension.

Kind regards,

Dr. Manuel Richter
Dr. Khodr Tello
Guest Editors

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• pulmonary hypertension
• right ventricle
• pressure–volume relationship
• systolic function
• right ventricle–pulmonary arterial coupling
• vascular remodelling