Special Issue "The Immune-Related Roles of Osteoclasts"
Deadline for manuscript submissions: 1 March 2023 | Viewed by 120
Interests: osteoclast; inflammation; osteoimmunology; osteoarticular diseases
Interests: inflammation; immunology; cell biology
It is our pleasure to introduce this Special Issue, “The Immune-Related Roles of Osteoclasts”, in the Biology journal.
Osteoclasts (OCLs) are giant multinucleated cells that are classically known for their bone-resorbing activity. However, increasing interest has emerged on the characterization of the immune role of OCLs based on their monocytic lineage and their phenotype. It has been demonstrated that OCLs act as phagocytes and antigen-presenting cells, and also produce various soluble factors. Moreover, different subsets of OCLs have been identified, with differences in their inflammatory or tolerogenic capabilities. Altogether, these features draw attention to the involvement of OCLs in both innate and adaptative immune responses confirming the crosstalk between bone and immune cells. Furthermore, these interactions open new lines of research that may connect the immune capacity of OCLs with the regulation of inflammation- and immune-mediated diseases.
This Special Issue welcomes contributions that address the characterization of OCLs as immune modulators or key participants in immune functions. Moreover, articles that focus on the connection between the immune functions of OCLs and the regulation of diseases with inflammatory or immune alterations will be highly appreciated. We welcome the submission of original articles, brief reports, reviews, and systematic reviews.
Dr. Lidia Ibáñez Torres
Dr. Paloma Guillem-Llobat
Dr. Cristina Sobacchi
Manuscript Submission Information
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- immune response