Special Issue "The Immune-Related Roles of Osteoclasts"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 1 March 2023 | Viewed by 120

Special Issue Editors

Dr. Lidia Ibáñez Torres
E-Mail Website
Guest Editor
Pharmacy Department, Cardenal Herrera-CEU University, 46115 Valencia, Spain
Interests: osteoclast; inflammation; osteoimmunology; osteoarticular diseases
Dr. Paloma Guillem-Llobat
E-Mail Website
Guest Editor
Department of Biomedical Sciences, Cardenal Herrera-CEU University, 46115 Valencia, Spain
Interests: inflammation; immunology; cell biology
Dr. Cristina Sobacchi
E-Mail Website
Guest Editor
1. CNR-IRGB, Milan Unit, via Fantoli 16/15, Milan, Italy
2. IRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy
Interests: RANKL; oxidative stress; murine models

Special Issue Information

Dear Colleagues,

It is our pleasure to introduce this Special Issue, “The Immune-Related Roles of Osteoclasts”, in the Biology journal.

Osteoclasts (OCLs) are giant multinucleated cells that are classically known for their bone-resorbing activity. However, increasing interest has emerged on the characterization of the immune role of OCLs based on their monocytic lineage and their phenotype. It has been demonstrated that OCLs act as phagocytes and antigen-presenting cells, and also produce various soluble factors. Moreover, different subsets of OCLs have been identified, with differences in their inflammatory or tolerogenic capabilities. Altogether, these features draw attention to the involvement of OCLs in both innate and adaptative immune responses confirming the crosstalk between bone and immune cells. Furthermore, these interactions open new lines of research that may connect the immune capacity of OCLs with the regulation of inflammation- and immune-mediated diseases.

This Special Issue welcomes contributions that address the characterization of OCLs as immune modulators or key participants in immune functions. Moreover, articles that focus on the connection between the immune functions of OCLs and the regulation of diseases with inflammatory or immune alterations will be highly appreciated. We welcome the submission of original articles, brief reports, reviews, and systematic reviews.

Dr. Lidia Ibáñez Torres
Dr. Paloma Guillem-Llobat
Dr. Cristina Sobacchi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • osteoclast
  • immune response
  • inflammation
  • tolerance
  • osteoimmunology

Published Papers

This special issue is now open for submission.
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