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Bioengineering publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in the Application of Mathematical and Computational Models in Biomedical Science and Engineering (2nd Edition)

edited by

Sundeep Singh

Roderick Melnik

and Manpreet Singh

submission deadline 31 Dec 2025 | 2 articles | Viewed by 6082 | Submission Open

Keywords: modeling and simulation; biomedical engineering; medical physics; multiphysics and multiscale models; biomedical therapy; neurotechnology; regenerative medicine; drug delivery; data-driven models; machine learning; patient-specific models

(This special issue belongs to the Section Biosignal Processing)

AI and Data Science in Bioengineering: Innovations and Applications

edited by

Muneer Ahmad

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5045 | Submission Open

Keywords: AI; data science; bioengineering; biomedical engineering; predictive modeling; machine learning; smart biomaterials; tissue engineering

(This special issue belongs to the Section Biosignal Processing)

Tissue Engineering and Regenerative Medicine Strategies for Biomedical Engineering

edited by Hun-Jin Jeong and

Solaiman Tarafder

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4741 | Submission Open

Keywords: tissue engineering; regenerative medicine; bioprinting; microfluidics; tissues on chip

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Emerging Nanomaterials and Nanotechnologies for Biomedical and Related Applications

edited by

Dipak Maity

and

Mangilal Agarwal

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4243 | Submission Open

Keywords: nanomaterials; nanotechnologies; biomedical applications; drug delivery systems; biosensors; tissue engineering; cancer therapeutics; diagnostics; biomedical imaging; photothermal therapy; chemodynamic therapy; cardiovascular diseases; infection control; neurological diseases; orthopedics

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Integrative Bioengineering in Orthopedic Surgery: From Regenerative Constructs to Precision Arthroplasty

edited by Man Soo Kim

submission deadline 31 Dec 2025 | 1 articles | Viewed by 4157 | Submission Open

Keywords: orthopedic bioengineering; tissue-engineered constructs; stem cell therapy; robotic surgery; AI-guided arthroplasty; smart implants; biomechanical modeling; scaffold-implant hybrid systems; regenerative surgery; precision orthopedics

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

3D Cell Culture Systems: Current Technologies and Applications

edited by

Peggy Stock

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4107 | Submission Open

Keywords: 3D cell culture; tissue engineering; biomaterials; drug discovery; cancer research; regenerative medicine; scaffold technology; high-throughput screening; organoids; in vitro models

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Engineering Neural Motor Control: From Mechanisms to Neural Interfaces

edited by Eizo Miyashita and Yuki Ueyama

submission deadline 31 Dec 2025 | 1 articles | Viewed by 4036 | Submission Open

Keywords: systems neuroscience; computational neuroscience; motor control; motor learning; motor dysfunction; rehabilitation; neuromodulation; human argumentation

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

New Sights of Deep Learning and Digital Model in Biomedicine

edited by

John A. St. Cyr

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3904 | Submission Open

Keywords: deep learning; digital model; biomedicine

(This special issue belongs to the Section Biosignal Processing)

Next-Generation Diagnostic and Therapy Systems for Neurodegenerative Diseases

edited by

Raji Sundararajan

and

Miad Faezipour

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3871 | Submission Open

Keywords: Alzheimer's disease; Parkinson's disease; machine learning; deep learning; neurostimulation; neuromodulation; artificial intelligence models

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Smart Applications and Technology for Cardiovascular Disease Management

edited by Alexander Samol and Sven Kaese

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3806 | Submission Open

Keywords: cardiovascular disease; smart applications; technology; wearable devices; artificial intelligence; telemedicine; virtual reality

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Dentistry Regenerative Medicine and Oral Bioengineering

edited by

Aylin Baysan

and Viresh Chopra

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3085 | Submission Open

Keywords: dentistry; regenerative medicine; oral bioengineering; tissue engineering; biomaterials

(This special issue belongs to the Section Regenerative Engineering)

Nerve Regeneration

edited by Luca Cicero,

Claudia Giampietri

and

Munmun Chattopadhyay

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2927 | Submission Open

Keywords: nerve regeneration; neuroengineering; biomaterials; stem cells; neuroprosthetics; biomedical devices

(This special issue belongs to the Section Regenerative Engineering)

Materials and Methods for Genetic and Cell-Based Therapy for Ocular Tissue

edited by Jesse Sengillo

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2574 | Submission Open

Keywords: retinal injury; retinal repair; biomaterials; surgical techniques; drug delivery systems; imaging modalities; stem cell therapy; gene therapy; regenerative medicine

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advances in Physical Therapy and Rehabilitation, 2nd Edition

edited by

Alvaro N. Gurovich

and

Shashwati Geed

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2275 | Submission Open

Keywords: biomedical engineering; rehabilitation engineering; biomechanics; motor control; applied physiology; 3D printing; additive manufacture; imaging; ultrasound

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Biological Wastewater Treatment and Resource Recovery, 2nd Edition

edited by

Omprakash Sarkar

Naresh Kumar Amradi

and J. Shanthi Sravan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1829 | Submission Open

Keywords: wastewater treatment; nutrient recovery; bioenergy generation; biobased products; anaerobic digestion; volatile fatty acids; bioammonium; bioelectricity

(This special issue belongs to the Section Biochemical Engineering)

Soft and Flexible Sensors for Biomedical Applications

edited by Martina Maselli and Parisa Pour Shahid Saeed Abadi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1742 | Submission Open

Keywords: stretchable electronics; flexible sensors; biomedical applications; wearable devices; conformable materials; health monitoring

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advanced Polymeric Materials for Bone, Cartilage, and Skeletal Muscle Regeneration

edited by

Jian Li

submission deadline 31 Dec 2025 | 1 articles | Viewed by 655 | Submission Open

Keywords: polymeric materials; bone regeneration; cartilage repair; skeletal muscle regeneration; 3D bioprinting; drug delivery systems; biodegradable polymers; smart materials

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Recent Advances in Biotechnology and Applied Microbiology

edited by

Ranjith Kumar Manoharan

and

Sathiyaraj Srinivasan

submission deadline 31 Dec 2025 | Viewed by 408 | Submission Open

Keywords: probiotics; postbiotics; biofilms; antimicrobial resistance; multidrug-resistant bacteria; genomics; microbiome; functional foods

(This special issue belongs to the Section Biochemical Engineering)

Emerging Roles of Large Language and Foundation Models in Pathology

edited by Zeynettin Akkus

submission deadline 31 Dec 2025 | Viewed by 316 | Submission Open

Keywords: large language models (LLMs); foundation models; digital pathology; histopathology image analysis; self-supervised learning; multi-modal AI; clinical decision support; retrieval-augmented generation (RAG); explainable AI (XAI); translational pathology

(This special issue belongs to the Section Biosignal Processing)

Bio-Scaffold Engineering for Soft Tissue Regenerative Medicine

edited by Zhonggang Feng

submission deadline 31 Dec 2025 | Viewed by 284 | Submission Open

Keywords: bio-scaffold engineering; decellularization; 3D bio-printing; hydrogel; polymer; natural materials; electrospinning; mechanical environment; cellular homeostasis; simulation

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advances and Applications of Neuroimaging

edited by Richard James Addante and Sujoy Ghosh-Hajra

submission deadline 31 Dec 2025 | Viewed by 267 | Submission Open

Keywords: neuroimaging; fMRI; EEG; ERPs; TMS; tDCS; tACS; rTMS; MRI; PET; iEEG; sEEG

(This special issue belongs to the Section Biosignal Processing)

Cardiac Tissue Engineering: From Tissue Regeneration to In Vitro Tissue Models

edited by

Elisabetta Rosellini

and Laurie Boyer

submission deadline 31 Dec 2025 | Viewed by 255 | Submission Open

Keywords: cardiac tissue engineering; heart-on-a-chip; stem cell therapy

(This special issue belongs to the Section Regenerative Engineering)

Bioactive Ceramics in Regenerative Medicine: From Bone Grafts to Dental Implants

edited by Wenfan Chen

submission deadline 31 Dec 2025 | Viewed by 254 | Submission Open

Keywords: bioceramics; dental implants; bone grafts; regenerative medicine; bone regeneration; biomaterials; three-dimensional printing

(This special issue belongs to the Section Regenerative Engineering)

Artificial Intelligence in Medical Image Processing and Segmentation, Third Edition

edited by

Bernard Chiu

submission deadline 31 Dec 2025 | Viewed by 237 | Submission Open

Keywords: medical image processing; image segmentation; computer-aided diagnosis; image-guided surgery; artificial intelligence

(This special issue belongs to the Section Biosignal Processing)

Recent Advances in Brain Stimulation Technology

edited by

Paolo Belardinelli

and

Giulia Liberati

submission deadline 31 Dec 2025 | Viewed by 235 | Submission Open

Keywords: brain stimulation; state-dependent brain stimulation; brain disorders; deep brain stimulation; transcranial magnetic stimulation; transcranial electrical stimulation; temporal interference stimulation

(This special issue belongs to the Section Biosignal Processing)

Voice Analysis Techniques for Medical Diagnosis

edited by

Shinichi Tokuno

and

Antonio Lanata

submission deadline 31 Dec 2025 | Viewed by 228 | Submission Open

Keywords: voice biomarker; diagnosis; monitoring; severity assessment

(This special issue belongs to the Section Biosignal Processing)

Machine Learning-Driven Innovations in Predictive Healthcare

edited by

Julfikar Haider

, Sang Won Park and

Mominul Ahsan

submission deadline 31 Dec 2025 | Viewed by 213 | Submission Open

Keywords: machine learning; clinical data analysis; medical decision support; disease prediction; personalized medicine

(This special issue belongs to the Section Biosignal Processing)

Advancements in Imaging and Sensing of Single Multi-Functional Nanoparticles, Viruses and Organelles

edited by Michelle A. Digman, Qimei Zhang, Jian Yang and

Georgios Alexandrakis

submission deadline 31 Dec 2025 | Viewed by 170 | Submission Open

Keywords: super-resolution microscopy; hyperspectral imaging; nanopore sensing; plasmonics; lipid nanoparticles; liposomes; quantum dots; virus; cell organelles

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Bioengineering Technologies for Spine Research

edited by Hyoungmin Kim

submission deadline 31 Dec 2025 | Viewed by 156 | Submission Open

Keywords: spine biomechanics; spinal implants and devices; computational modeling; tissue engineering; biomedical imaging; artificial intelligence; motion analysis; surgical robotics; regenerative medicine; predictive modeling; personalized spine care; translational bioengineering; smart materials; image-guided interventions

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Recent Advances in Biomedical Imaging, Third Edition

edited by

Cuneyt M. Alper

submission deadline 31 Dec 2025 | Viewed by 151 | Submission Open

Keywords: imaging innovations; advances in imaging CT; scans MRI; ultrasound nuclear medicine; PET fluoroscopy; interventional radiology; combined imaging modalities; automated segmentation; machine learning

(This special issue belongs to the Section Biosignal Processing)

Advancements in Imaging Techniques for Assessing Bone Health and Regeneration

edited by William Querido

submission deadline 31 Dec 2025 | Viewed by 138 | Submission Open

Keywords: bone imaging techniques; multimodal and spectral imaging; high-resolution microscopy and tomography; advanced bone histopathology; bone composition and microarchitecture; machine learning in biomedical imaging

(This special issue belongs to the Section Biosignal Processing)

Oral Wound Healing and Material Engineering

edited by

Steven L. Goudy

submission deadline 31 Dec 2025 | Viewed by 122 | Submission Open

Keywords: oral; healing; regeneration; mucosa; bone; biomaterial

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Transformative Technologies for Bioengineering and Regenerative Medicine

edited by

Salil Desai

and Joshua Hunsberger

submission deadline 10 Jan 2026 | 1 articles | Viewed by 2102 | Submission Open

Keywords: regenerative medicine; tissue engineering; artificial intelligence; digital twins; IIoTs; biomaterials; biomanufacturing; cybersecurity

(This special issue belongs to the Section Regenerative Engineering)

Gene Delivery for Cancer Therapy

edited by Huiyi Liang and Tianqi Nie

submission deadline 10 Jan 2026 | Viewed by 275 | Submission Open

Keywords: gene delivery; drug delivery; nanoparticles; hydrogel; cancer

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Electrical Impedance Tomography: New Advances in Biomedical Signal Processing

edited by Meng Dai

submission deadline 12 Jan 2026 | 2 articles | Viewed by 3421 | Submission Open

Keywords: electrical impedance tomography (EIT); signal processing; clinical noises; body movement; radiation-free imaging; image reconstruction; machine learning; artificial intelligence; real-time EIT; quantitative EIT

(This special issue belongs to the Section Biosignal Processing)

Development and Application of Extracellular Vesicles for Neurodegenerative Diseases

edited by Mangesh Dattu Hade

submission deadline 12 Jan 2026 | Viewed by 223 | Submission Open

Keywords: extracellular vesicles (EVs); neurodegenerative diseases; exosomes; blood– brain barrier; biomarkers; therapeutic nanocarriers

(This special issue belongs to the Section Regenerative Engineering)

Tumor Mechanobiology and Translational Insights

edited by

Yousef Javanmardi

submission deadline 15 Jan 2026 | Viewed by 282 | Submission Open

Keywords: tumor mechanobiology; tumor microenvironment; mechanotransduction; ECM remodeling; tissue mechanics; translational mechanobiology

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Design and Synthesis of Functional Deuterated Biomaterials

edited by Nageshwar R. Yepuri

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5267 | Submission Open

Keywords: deuterated lipids; deuterated phospholipids; lipid nano particle; lipid nano discs; deuterated fatty acids; deuterated amino acids

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Engineering Stem Cells and Their Derivatives for Wound Healing and Tissue Regeneration

edited by Yueh Hsun Kevin Yang

submission deadline 25 Jan 2026 | Viewed by 90 | Submission Open

Keywords: stem cells; extracellular vesicles; biomaterials; immunoengineering; gene editing; regenerative medicine; wound healing

(This special issue belongs to the Section Regenerative Engineering)

New Sight for the Treatment of Dental Diseases: Updates and Direction

edited by

Angelo Michele Inchingolo

submission deadline 31 Jan 2026 | 8 articles | Viewed by 42513 | Submission Open

(This special issue belongs to the Section Regenerative Engineering)

Medical Imaging Analysis: Current and Future Trends

edited by He Zhao and

Lin Gu

submission deadline 31 Jan 2026 | 7 articles | Viewed by 11536 | Submission Open

Keywords: computer vision; artificial intelligence (AI); multi-modality learning; disease progression monitoring; explainable AI; human-computer interaction

(This special issue belongs to the Section Biosignal Processing)

Dynamic Insights: Unveiling the Biomechanics of Sport Through Motion Analysis

edited by

Ukadike Chris Ugbolue

and Sang-Hoon Yeo

submission deadline 31 Jan 2026 | 6 articles | Viewed by 10114 | Submission Open

Keywords: artificial intelligence; augmented reality; biomechanics; E-sports; instrumentation; kinesiology; machine learning; motion analysis; performance enhancement; virtual reality; wearable technology

(This special issue belongs to the Section Biomechanics and Sports Medicine)

Technological Advances for Gait and Balance Assessment

edited by Alessandro Zampogna,

Silvia Del Din

and

Florenc Demrozi

submission deadline 31 Jan 2026 | 5 articles | Viewed by 10065 | Submission Open

Keywords: novel diagnostic devices and wearable sensors; machine learning and artificial intelligence applications; biomechanical analysis; telemedicine and remote monitoring solutions

(This special issue belongs to the Section Biosignal Processing)

Advanced Technology for Implant Polymers in Orthopaedics, Spine, and Trauma

edited by Steven M. Kurtz, Hannah Spece,

Pierangiola Bracco

and

Francisco Javier Medel

submission deadline 31 Jan 2026 | 4 articles | Viewed by 8877 | Submission Open

Keywords: UHMWPE; highly crosslinked UHMWPE; HXLPE; PEEK; PEKK; PAEK; additive manufacturing; AM; 3D printing

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Innovative Bioengineering Paradigms for Cardiac Repair: Cell-Based and Cell-Free Approaches

edited by

Jialiang Liang

and Xingyu He

submission deadline 31 Jan 2026 | 3 articles | Viewed by 6797 | Submission Open

Keywords: cardiac regeneration; cardiac repair; stem cells; tissue engineering; cell transplant; gene delivery; extracellular vesicles; nanotechnology; immunomodulation; lineage reprogramming

(This special issue belongs to the Section Regenerative Engineering)

Disease Diagnosis and Therapy Using Viral Vectors

edited by

Srividhya Venkataraman

and

Kathleen Hefferon

submission deadline 31 Jan 2026 | 1 articles | Viewed by 6375 | Submission Open

Keywords: gene therapy; viral vectors; genetic disease

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Low-Back Pain: Assessment and Rehabilitation Research

edited by

Giustino Varrassi

and

Giacomo Farì

submission deadline 31 Jan 2026 | 2 articles | Viewed by 4869 | Submission Open

Keywords: chronic pain; wearable technologies; computational modeling; biomechanical analysis; assistive devices; sensor-based functional assessments

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Bioengineering in a Generative AI World

edited by

Yifan Zhao

, Ulas Bagci and Yuxiang Zhou

submission deadline 31 Jan 2026 | 2 articles | Viewed by 4630 | Submission Open

Keywords: generative AI; bioengineering; machine learning; synthetic biology; drug discovery

(This special issue belongs to the Section Biosignal Processing)

Digital Technologies to Improve Diagnostic Cytopathology: Future Outlook

edited by

Enrico Giarnieri

submission deadline 31 Jan 2026 | 1 articles | Viewed by 3833 | Submission Open

Keywords: machine learning; cytopathology; digital cytology; computer-aided diagnosis; virtual reality; natural language process

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

New Sights of Machine Learning and Digital Models in Biomedicine

edited by Hatem Alhadainy

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3612 | Submission Open

Keywords: machine learning; biomedical imaging; predictive modeling; medical data analytics; genomics; precision medicine; bioinformatics; machine learning algorithms; computer-aided diagnosis; imaging analysis; clinical decision support; electronic health records (EHR); disease prediction simulation models; virtual patients; drug discovery; health informatics

(This special issue belongs to the Section Biosignal Processing)

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