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Bioengineering
Special Issues
Biomaterials for Chronic Wound Healing
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Biomaterials for Chronic Wound Healing

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 9395

Special Issue Editors

Dr. Hongbin Li

E-Mail Website
Guest Editor
College of Light Industry and Textile, Qiqihar University, Qiqihar 161000, China
Interests: hydrogel; cellulose; 3D bioprinting; wound dressing; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Feng Cheng

E-Mail Website
Guest Editor
MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China
Interests: hydrogels; biomaterials; bioprinting; microfluidics; wound dressing; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Guangyu Wu

E-Mail Website
Guest Editor
College of Biology and the Environment, Co-Innovation Center for the Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, China
Interests: stimuli-responsive; microcapsules; self-assembly; enzyme catalysis; smart polymer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue on “Biomaterials for Chronic Wound Healing” covers the wide range of physical, biological and chemical sciences that underpin the design of function biomaterials directed to chronic wound healing. Within this context, a broad range of subjects, including materials, structure, manufacturing technology, and theoretical and applications will be discussed.

Wound dressing has opened a new avenue for the engineering of functional biomaterials based on various manufacturing techniques and strategies. However, there remain some significant challenges, such as the unmet demand for specific chronic wound healing. Single-component wound dressing might suffer the difficulties of providing comprehensively superior properties to the complicated wound situation. Compositing or combining different components has been a simple yet powerful methodology to develop functional wound dressing. The rational design based on the interplay between different biomaterials might further improve the function of the wound dressing. Thus, this Special Issue entitled “Biomaterials for Chronic Wound Healing” will highlight the advances in exploring composite or multi-component biomaterials for chronic wound healing applications.

Therefore, this Special Issue of Biomaterials for chronic wound healing serves to provide a platform for researchers to report results and findings, and we sincerely invite you to contribute your research papers and review articles to this Special Issue with a focus on novel wound dressings for chronic wound healing applications.

Dr. Hongbin Li
Dr. Feng Cheng
Dr. Guangyu Wu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • chronic wound dressing
  • synthesis and characterization
  • antibacterial
  • tissue repair and regeneration

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Published Papers (4 papers)

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Research

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16 pages, 4410 KiB  
Article
A Novel Dehydrated Human Umbilical Cord Particulate Medical Device: Matrix Characterization, Performance, and Biocompatibility for the Management of Acute and Chronic Wounds
by Dominique Croteau, Molly Buckley, Morgan Mantay, Courtney Brannan, Annelise Roy, Barbara Barbaro and Sarah Griffiths
Bioengineering 2024, 11(6), 588; https://doi.org/10.3390/bioengineering11060588 - 8 Jun 2024
Viewed by 1877
Abstract
Chronic wounds present a significant socioeconomic burden forecasted to increase in prevalence and cost. Minimally manipulated human placental tissues have been increasingly employed and proven to be advantageous in the treatment of chronic wounds, showing improved clinical outcomes and cost-effectiveness. However, technological advances [...] Read more.
Chronic wounds present a significant socioeconomic burden forecasted to increase in prevalence and cost. Minimally manipulated human placental tissues have been increasingly employed and proven to be advantageous in the treatment of chronic wounds, showing improved clinical outcomes and cost-effectiveness. However, technological advances have been constrained by minimal manipulation and homologous use criteria. This study focuses on the characterization of a novel dehydrated human umbilical cord particulate (dHUCP) medical device, which offers a unique allogeneic technological advancement and the first human birth tissue device for wound management. Characterization analyses illustrated a complex extracellular matrix composition conserved in the dHUCP device compared to native umbilical cord, with abundant collagens and glycosaminoglycans imbibing an intricate porous scaffold. Dermal fibroblasts readily attached to the intact scaffold of the dHUCP device. Furthermore, the dHUCP device elicited a significant paracrine proliferative response in dermal fibroblasts, in contrast to fibrillar collagen, a prevalent wound device. Biocompatibility testing in a porcine full-thickness wound model showed resorption of the dHUCP device and normal granulation tissue maturation during healing. The dHUCP device is a promising advancement in wound management biomaterials, offering a unique combination of structural complexity adept for challenging wound topographies and a microenvironment supportive of tissue regeneration. Full article
(This article belongs to the Special Issue Biomaterials for Chronic Wound Healing)
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16 pages, 3617 KiB  
Article
Technical Evaluation of a New Medical Device Based on Rigenase in the Treatment of Chronic Skin Lesions
by Eugenia Romano, Claudio Campagnuolo, Roberta Palladino, Giulia Schiavo, Barbara Maglione, Cristina Luceri and Natascia Mennini
Bioengineering 2023, 10(9), 1022; https://doi.org/10.3390/bioengineering10091022 - 29 Aug 2023
Cited by 5 | Viewed by 1753
Abstract
Chronic wound is characterized by slow healing time, persistence, and abnormal healing progress. Therefore, serious complications can lead at worst to the tissue removal. In this scenario, there is an urgent need for an ideal dressing capable of high absorbency, moisture retention and [...] Read more.
Chronic wound is characterized by slow healing time, persistence, and abnormal healing progress. Therefore, serious complications can lead at worst to the tissue removal. In this scenario, there is an urgent need for an ideal dressing capable of high absorbency, moisture retention and antimicrobial properties. Herein we investigate the technical properties of a novel advanced non-woven triple layer gauze imbibed with a cream containing Rigenase, an aqueous extract of Triticum vulgare used for the treatment of skin injuries. To assess the applicability of this system we analyzed the dressing properties by wettability, dehydration, absorbency, Water Vapor Transmission Rate (WVTR), lateral diffusion and microbiological tests. The dressing showed an exudate absorption up to 50%. It created a most environment allowing a proper gaseous exchange as attested by the WVTR and a controlled dehydration rate. The results candidate the new dressing as an ideal medical device for the treatment of the chronic wound repairing process. It acts as a mechanical barrier providing a good management of the bacterial load and proper absorption of abundant wound exudate. Finally, its vertical transmission minimizes horizontal diffusion and side effects on perilesional skin as maceration and bacterial infection. Full article
(This article belongs to the Special Issue Biomaterials for Chronic Wound Healing)
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15 pages, 6344 KiB  
Article
Outcome of Application of Cryopreserved Amniotic Membrane Grafts in the Treatment of Chronic Nonhealing Wounds of Different Origins in Polymorbid Patients: A Prospective Multicenter Study
by Alzbeta Svobodova, Vojtech Horvath, Lukas Balogh, Martina Zemlickova, Radovan Fiala, Jan Burkert, Marek Brabec, Petr Stadler, Jaroslav Lindner, Jan Bednar and Katerina Jirsova
Bioengineering 2023, 10(8), 900; https://doi.org/10.3390/bioengineering10080900 - 29 Jul 2023
Cited by 5 | Viewed by 1402
Abstract
To compare the therapeutic efficacy of cryopreserved amniotic membrane (AM) grafts and standard of care (SOC) in treating nonhealing wounds (NHW) through a prospective multicenter clinical trial, 42 patients (76% polymorbid) with 54 nonhealing wounds of various etiologies (mainly venous) and an average [...] Read more.
To compare the therapeutic efficacy of cryopreserved amniotic membrane (AM) grafts and standard of care (SOC) in treating nonhealing wounds (NHW) through a prospective multicenter clinical trial, 42 patients (76% polymorbid) with 54 nonhealing wounds of various etiologies (mainly venous) and an average baseline size of 20 cm2 were included. All patients were treated for at least 6 weeks in the center before they were involved in the study. In the SOC group, 29 patients (36 wounds) were treated. If the wound healed less than 20% of the baseline size after 6 weeks, the patient was transferred to the AM group (35 patients, 43 wounds). Weekly visits included an assessment of the patient’s condition, photo documentation, wound debridement, and dressing. Quality of life and the pain degree were subjectively reported by patients. After SOC, 7 wounds were healed completely, 1 defect partially, and 28 defects remained unhealed. AM application led to the complete closure of 24 wounds, partial healing occurred in 10, and 9 remained unhealed. The degree of pain and the quality of life improved significantly in all patients after AM application. This study demonstrates the effectiveness of cryopreserved AM grafts in the healing of NHW of polymorbid patients and associated pain reduction. Full article
(This article belongs to the Special Issue Biomaterials for Chronic Wound Healing)
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Review

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17 pages, 350 KiB  
Review
Cellular and Molecular Events of Wound Healing and the Potential of Silver Based Nanoformulations as Wound Healing Agents
by Caroline Tyavambiza, Mervin Meyer and Samantha Meyer
Bioengineering 2022, 9(11), 712; https://doi.org/10.3390/bioengineering9110712 - 19 Nov 2022
Cited by 23 | Viewed by 3564
Abstract
Chronic wounds are a silent epidemic threatening the lives of many people worldwide. They are associated with social, health care and economic burdens and can lead to death if left untreated. The treatment of chronic wounds is very challenging as it may not [...] Read more.
Chronic wounds are a silent epidemic threatening the lives of many people worldwide. They are associated with social, health care and economic burdens and can lead to death if left untreated. The treatment of chronic wounds is very challenging as it may not be fully effective and may be associated with various adverse effects. New wound healing agents that are potentially more effective are being discovered continuously to combat these chronic wounds. These agents include silver nanoformulations which can contain nanoparticles or nanocomposites. To be effective, the discovered agents need to have good wound healing properties which will enhance their effectiveness in the different stages of wound healing. This review will focus on the process of wound healing and describe the properties of silver nanoformulations that contribute to wound healing. Full article
(This article belongs to the Special Issue Biomaterials for Chronic Wound Healing)
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