Biochemical Regulatory Mechanisms in Ubiquitin-Proteasome System

Dear Colleagues,

Even in the era of big data, dissecting a biochemical process is still critical to understanding the processes in biology. The field of the ubiquitin–proteasome system was born solely of biochemical approaches, and the time of “biochemistry on proteolysis” is far from being over, even though molecular biology and genetics has become also essential to functional studies.

Protein degradation is no longer a neglected area. Tens of thousands of papers are published on this topic each year, solving many mechanistic issues in the field. However, many key questions remain unresolved, especially regarding its spatiotemporal regulation, specificity in myriad signaling transduction, complex ubiquitin chain linkages, and crosstalk with autophagy. Therefore, instead of identifying the physiological roles of the system (or pathological implications from its aberration), we want to bring to the readers an updated mechanistic view on the ubiquitin–proteasome system. Studies on the basic biochemistry can provide the core information of the ever-growing data in the field.

For this Special Issue, we welcome original research and mini-review articles covering the mechanistic aspects of protein degradation and the related enzymes. Articles discussing methodological approaches with test tubes or living cells are also encouraged.

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• ubiquitin
• ubiquitin-like protein
• E1 ubiquitin-activating enzyme
• E2 ubiquitin-conjugating enzyme
• E3 ubiquitin ligase
• proteasome
• deubiquitinating enzyme
• ubiquitin receptor