Special Issue "Overlap of Allergic Asthma and Eosinophilic Adult-Onset Asthma"
Deadline for manuscript submissions: closed (6 August 2022) | Viewed by 427
Allergic asthma was first described in the medical literature 200 years ago. As of 1918, Rackeman had already reported on 150 cases of eosinophilic perineal asthma with concomitant nasal polyposis. However, it was only 10 years ago that cluster analyses were used to describe different phenotypes of asthma, including allergic early-onset and eosinophilic adult-onset asthma.
Individuals with eosinophilic adult-onset asthma often lack relevant bronchial hyperresponsiveness, leading to symptoms that mimic those of chronic obstructive pulmonary disorder (COPD). These asthma patients, who often have a history of cigarette smoking, suffer from swelling of the bronchial mucosa, mucoid impaction with progressive exertional dyspnoea, and irreversible bronchial obstruction after intake of SABA. If a differential blood cell count indicating eosinophilia is done prior to steroid treatment and spirometry is not performed prior to and directly after a steroid burst, these patients are often falsely diagnosed with COPD.
In addition to the co-existence of COPD and asthma may occur, allergic asthma and non-IgE-driven eosinophilic inflammation of the airways may occur simultaneously. This Special Issue aims to present a collection of articles that shed light on the two main phenotypes related to these conditions as well as the different forms of disease overlap.
Dr. Thomas Rothe
Manuscript Submission Information
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- allergic asthma
- clinically relevant sensitization
- eosinophilic adult-onset asthma
- chronic hyperplastic eosinophilic sinusitis