Special Issue "Overlap of Allergic Asthma and Eosinophilic Adult-Onset Asthma"

A special issue of Allergies (ISSN 2313-5786). This special issue belongs to the section "Asthma/Respiratory".

Deadline for manuscript submissions: closed (6 August 2022) | Viewed by 427

Special Issue Editor

Dr. Thomas Rothe
E-Mail Website
Guest Editor
1. Pneumologie, Kantonsspital Graubünden, 7000 Chur, Switzerland
2. European Respiratory Society (ERS), 1003 Lausanne, Switzerland
Interests: type 2 asthma

Special Issue Information

Dear Colleagues,

Allergic asthma was first described in the medical literature 200 years ago. As of 1918, Rackeman had already reported on 150 cases of eosinophilic perineal asthma with concomitant nasal polyposis. However, it was only 10 years ago that cluster analyses were used to describe different phenotypes of asthma, including allergic early-onset and eosinophilic adult-onset asthma.

Individuals with eosinophilic adult-onset asthma often lack relevant bronchial hyperresponsiveness, leading to symptoms that mimic those of chronic obstructive pulmonary disorder (COPD). These asthma patients, who often have a history of cigarette smoking, suffer from swelling of the bronchial mucosa, mucoid impaction with progressive exertional dyspnoea, and irreversible bronchial obstruction after intake of SABA. If a differential blood cell count indicating eosinophilia is done prior to steroid treatment and spirometry is not performed prior to and directly after a steroid burst, these patients are often falsely diagnosed with COPD.

In addition to the co-existence of COPD and asthma may occur, allergic asthma and non-IgE-driven eosinophilic inflammation of the airways may occur simultaneously. This Special Issue aims to present a collection of articles that shed light on the two main phenotypes related to these conditions as well as the different forms of disease overlap.

Dr. Thomas Rothe
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Allergies is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • allergic asthma
  • clinically relevant sensitization
  • eosinophilic adult-onset asthma
  • chronic hyperplastic eosinophilic sinusitis

Published Papers

There is no accepted submissions to this special issue at this moment.
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