Upon the completion of his medical degree and urology residency at St. Radboud University Hospital in Nijmegen, The Netherlands, he worked there as a urologist from 1992 to 2002. He was appointed Professor and Chair at the Department of Urology at Amsterdam UMC, Amsterdam, The Netherlands, from 2002 to 2018. He holds, since 2018, the position of Professor in Urology at Istanbul Medipol University in Istanbul, Turkiye, and since 2025, also the position of Professor in Urology at Bashkir State Medical University in Ufa, Russia. His main fields of interest are minimally invasive urological surgery, endourology, ablative treatments, and urological imaging. He is a founding co-chairman of the EAU Section of Uro-Technology (ESUT) and the founding chairman of the European Association of Urology (EAU) BPH guidelines committee. He served as a board member of the Society of Endourology during 1996–2016. He is strongly committed to research and is the founding-chair of the CROES (Clinical Research Office of the Endourology Society). He held, from 2016 to 2022, the position of General Secretary of the Societe International d'Urologie and is, since 2024, the President of the Societe International d'Urologie. Dr. de la Rosette is the (co)author of over 750 peer-reviewed publications, has authored many book chapters, and has an H-index of 113.