Author Biographies

She is a preclinical study manager in Boiron Laboratories, a pharmaceutical company based near Lyon-France. She has a master's degree in biochemistry with specialities in immunology, pharmacology, and toxicology. She has 18 years of experience in Research in academic laboratories and private biotechnology and pharmaceutical companies in Lyon-France. She has expertise in several techniques: primary cell culture and immortalized cell lines, 3D cell culture with a scaffold or coating for tissue engineering, transfection and promoter assay, cell migration assay, immunochemistry and immunofluorescence, confocal microscopy, time-lapse microscopy, molecular biology and biochemical analysis. Her research work focuses on: cartilage tissue engineering and cell-ECM signalling via integrin receptors with the mechanical stimulation or growth factors, oncology, bacteria in microbiota, inflammation and oxidative stress responses in immune cell models. She has published 10 peer reviewed papers (ORCID id: https://orcid.org/0009-0000-3124-0056)
She is a preclinical study manager in Boiron (a pharmaceutical company based near Lyon-France). She earned her BTEC Higher National Diploma in Biological Analyses and Biotechnologies in 2009 and has worked in BOIRON since 2010, and she joined the research team in 2013 with 12 years of experience in research. She has expertise in several laboratory techniques: cell culture (primary cells and cell lines), microscopy and especially oxidative stress, flow cytometry and ELISA development. Her research focuses on oxidative stress and the inflammation response. She has published three peer reviewed papers.
Gaël Runel is a Project Manager at BioMeca SAS, with a strong background in Molecular and Cellular Biology. He earned his Ph.D. from Université Claude Bernard Lyon 1 in 2022, specializing in Biomechanics, under the supervision of Ingrid Masse. His thesis focused on the role of mechanical forces within the epidermis during the growth of cutaneous melanoma. Gaël has gained valuable experience through research roles at CRCL and BioMeca SAS, where he has contributed to the understanding of cancer cell biomechanics. His current research focuses on the biomechanical properties of cells and tissues, the extracellular matrix, and the development of innovative biomechanical tools. His earlier research delved into cytoskeletal reorganization and cell rigidity.
Julien Chlasta is the founder and CEO of BioMeca, a biotech company in Lyon, France, that specializes in biophysical analysis of biological systems. He completed his Ph.D. in Cellular Biology at Université Claude Bernard Lyon 1 in 2016, focusing on the role of the basement membrane in epithelial morphogenesis in Drosophila melanogaster. Since co-founding BioMeca in 2017, Julien has driven the development of advanced biophysical measurement techniques, particularly for skin and hair analysis, gaining recognition from the cosmetics and pharmaceutical sectors. His research interests include extracellular matrix mechanics, epithelial morphogenesis, and biophysical tool development for biomedical use.
A senior scientist responsible for preclinical research projects in Boiron (a pharmaceutical company based near Lyon-France), she has a Ph.D. in Biochemistry and Cell Biology with 25 years of experience in research. She worked in the UK for 8 years at the Institute of Food research-Quadram Institute in Norwich and for 8 years in private biotechnology companies (Biovays and ALQAN) in France specializing in biomarker analysis. Her expertise includes various techniques: confocal microscopy images, cell culture (primary cells and cell lines), ELISA, immunochemistry and immunofluorescence, frozen tissue sections, molecular biology, protein purification, HPLC for flavonoids and biochemical analysis. Her research work focuses on: annexin proteins, mucins (glycoproteins), cytosolic beta glucosidase, quercetin and metabolites, atherosclerosis models, sialic acids, gut microbiota (Ruminococcus gnavus), inflammation and immune markers, and oxidative stress. In total, she has published 19 peer reviewed papers (ORCID id : https://orcid.org/0000-0002-2664-7553).
Head of the Research department in Boiron (a pharmaceutical company based near Lyon-France), Stéphanie Chanut holds a Doctor of Pharmacy degree and an engineering degree in Biochemistry and Biotechnology from INSA Lyon (National Institute of Applied Sciences in Lyon, France). Currently, she manages teams responsible for basic, preclinical and clinical research.  After 19 years of work experience in pharmaceutical companies, mainly in Boiron, she has an extensive expertise in Regulatory Affairs and analytical development. She has led laboratories in charge of research and/or development for about 10 years and has contributed to the publication of several scientific articles on various topics. Member of the French Pharmacopoeia, Homeopathic Pharmacopoeia of the United States and SFSTP (French Society of Pharmaceutical Sciences and Techniques), her expertise includes mainly liquid and gas chromatography, immunochemistry and molecular biology techniques, immune and inflammation mechanisms and pharmaceutical regulation.
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