Dr. Anna N. Berlina is a Senior Researcher at the A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences. She is a specialist in the development of bioanalytical and immunochemical test systems for the determination of low- and high-molecular-weight compounds. Her research interests are related to the application of different labels in immunoassay, research and development of analytical test systems for the detection of different contaminants, the synthesis and characterization of nanoparticles, the conjugation of proteins and aptamers with different labels, food and environmental contaminants, water and food safety, biologically active compounds using chemiluminescence, colorimetric, fluorescent detection, and conjugation techniques and aptamer application. She is the author of more than 55 papers.
Dr. Nadezhda S. Komova is a researcher of the Institute of Biochemistry, Centre of Biotechnology of the Russian Academy of Sciences, Moscow. She is a specialist in the development of bioanalytical test systems for the determination of low-molecular compounds by optical detection methods and structural characterization of ligand–receptor complexes. She has significant experience in the metrological characterization of bioanalytical test systems, the selection and justification of the most effective methods for sample preparation of various test biomaterials, as well as the synthesis of composite materials based on alumina gels containing silver nanoparticles for simultaneous concentration and SERS detection. She is a co-author of 24 papers in peer-reviewed journals.
Dr. Kseniya V. Serebrennikova is a researcher at the Institute of Biochemistry, Centre of Biotechnology of the Russian Academy of Sciences, Moscow. Her research interests lie in the development of immunoassay systems with various markers and signal recording systems. Her published articles describe a number of immunoassay systems for the detection of low-/high-molecular analytes with colorimetric detection, as well as biosensors coupled with surface-enhanced Raman spectroscopy. She has co-authored 19 peer-reviewed papers and approximately 6 patents.
Dr. Anatoly V. Zherdev is a leading researcher at the Institute of Biochemistry, Centre of Biotechnology of the Russian Academy of Sciences, Moscow. His scientific interests lie in the fields of regularities of intermolecular interactions in immunosensors, obtaining and characterizing bioreceptor–nanoparticle complexes, and developing new immunoanalytical techniques for medicine, agriculture, food safety and environmental monitoring. Dr. Zherdev participated/s in several international projects covering different aspects of food safety and food-related risks. He is a co-author of ~330 papers in peer-reviewed journals and ~30 patents presenting new immunoassays for various compounds. His work on the development of large-scale manufacturing of immunochromatographic strips for on-site analyses was awarded a prize by the Russian government.
The researches of Prof. Dzantiev are directed at studying quantitative regularities of antigen–antibody interactions and the development of new immunochemical techniques for the detection of biologically active compounds. The relations between the properties of immunoreagents and kinetic and equilibrium parameters of the antigen–antibody reaction are studied theoretically and experimentally. Structural changes of protein antigens in the course of their interaction with antibodies are characterized, including antibody-assisted refolding and modulation of catalytic activities of enzymes. The substances significant for medicine, agriculture, biotechnology and environmental monitoring are used as model antigens. This enables us to determine common regularities and specific features of the immunochemical interactions. New assay formats and label systems are proposed that ensure the growth of sensitivity and rapidity of testing. The efficacy of the novel methods for practical purposes is characterized; technologies for scaled production of immunoanalytical test systems are developed jointly with manufacturers. The laboratory of Prof. Dzantiev realizes the full cycle of the development of immunoanalytical techniques, beginning with obtaining antibodies and finalizing with the creation of manufacturing technologies.
