Dr. Leslie A. Lyons is the Gilbreath McLorn Endowed Professor of Comparative Medicine at
the University of Missouri, College of Veterinary Medicine. She received her
PhD degree from the University of Pittsburgh. Dr. Lyons was trained in human
genetics, and her postdoctoral fellowship focused on developing genetic
resources for comparative gene mapping across mammalian species. Her research
is currently primarily focused on heritable diseases and traits and the population
dynamics of the domestic cat. Specific diseases remain of high priority,
including polycystic kidney disease (PKD), skin abnormalities, structural
defects, and heritable blindness. An expectation of the research is to develop
drug and gene therapies and translational efforts, for one or more of these
abnormalities to better develop the cat as an animal model for human disease.
Dr. Lyons has also supported the community by providing DNA studies for the
first cloned domestic cat, wildcat, and sand cat and the GFP transgenic cat.
Her laboratory has identified over 30 mutations in over 20 genes, including many
diseases, several coat colors, several fur types, and cat AB/B blood type. She
recently launched the 99 Lives Cat Genome Sequencing Initiative: an effort to
have deep coverage sequencing of cats with inherited diseases and as an SNP
resource for the community.
