Yugandhar Kothapalli
earned his Ph.D. in organic chemistry from Jawaharlal Nehru Technological
University (JNTU) in 2018. Following this, he pursued postdoctoral research at
the Huntsman Cancer Institute (HCI) at the University of Utah, USA, from 2020
to 2021. His research focused on synthesizing biologically active novel
heterocyclic NCEs and PROTACs for various cancer diseases. Currently, Dr.
Kothapalli is affiliated with the University of Georgia, Pharmaceutical and
Biomedical Sciences department in the USA, where he is dedicated to antiviral
drug discovery and development. His current research involves synthesizing
modified nucleosides/nucleotides against various emerging DNA/RNA viruses. Before
relocating to the USA, he worked at one of India's premier contract research
organizations (CRO), where he collaborated closely with many pharmaceutical and
small biotech firms. His extensive expertise and diverse background in
designing, synthesizing, and optimizing SAR for advanced compounds highlight
his exceptional capabilities in the academic and pharmaceutical fields.
Ransom A. Jones graduated valedictorian with both a
BS in Pharmaceutical Sciences and an MS in Pharmaceutical and Biomedical
Sciences from the University of Georgia. He joined Prof. Chu/Dr. Singh's lab in
2021, where his graduate training specialized in the design and synthesis of
carbocyclic nucleoside analogs. His skills include organic synthesis, HPLC
method development, validations/verifications, and analytical method
development. Currently, he is working as an analytical scientist in a
pharmaceutical company.
Prof. David Chu is a Distinguished Research Professor, Emeritus
in the Department of Pharmaceutical and Biomedical Sciences at The University
of Georgia. He established an internationally known academic drug discovery
program for antiviral research. He has been serving as Director of Drug
Discovery Group at UGA since 1989. He discovered more than 7 clinical
candidates for HIV, cancer & HBV; his anti-hepatitis B virus (HBV) agent,
clevudine, marketed under the trade name Levovir, is being used for the treatment
of chronic hepatitis B (CHB) infections in several Asian countries. Most
recently, his research group has discovered FMCA for drug-resistant HBV, as
well as L-BHDU for the treatment of shingles. Currently, his research group
focuses on the drug discovery project for SARS-COV-2, VZV, and HSA 1& 2
infections. He is the recipient of prestigious international awards in
antiviral drug discovery fields; John A. Montgomery Award
(The International RoundTable Society), Antonin
Holy Award (Society of International Antiviral Research). He is an
elected Fellow of the National Academy of Inventors & American
Association of Advancement of Science. He is a recipient of
the NIH Merit Award and Inventor
of the Year Award of UGA. He has published over 300
peer-reviewed research papers and received 60 US patents. Whenever viruses
threatened human health, his group has been at the forefront of the discovery
of antiviral agents.
Dr. Singh is an organic medicinal
chemist with drug discovery and development expertise. Currently, he is working
as a lecturer in the College of Pharmacy at the University of Georgia. Dr.
Singh has also served as a senior scientist in various pharmaceutical
companies, and his research goal is to develop new antiviral and anticancer
agents as pre-clinical and clinical drug candidates. He is a leading scientist
in the design and synthesis of altered nucleoside and nucleotide analogs, which
specifically target DNA/RNA polymerase of viruses without causing toxicity to
the host. In this effort, his laboratory developed FMCAP
(2′-Fluoro-6′-methylenecarbocyclic Adenosine Phosphoramidate) as a pre-clinical
candidate for the treatment of drug-resistant hepatitis B virus (HBV) and
POM-L-BHDU-MP for the treatment of shingles and HSV-1 infections. The outbreak
of severe acute respiratory syndrome caused by SARS-CoV-2, known as COVID-19
infection, fueled his research to develop a potential drug candidate against
emerging RNA/DNA viruses and to find new drug-like molecules against the Nipah,
SARS-CoV-2, Ebola, RSV, HBV, VZV, EBV, dengue, and influenza viruses.