Prof. Jacques Fantini has a position as a Professor of Biochemistry and currently is working at the Department of Biology, Faculty of Medicine, University of Aix-Marseille, Marseille, France. He received his Ph.D. in Biochemistry and Molecular Biology from the University of Provence, Marseille, France. He started his scientific career by studying the energetic metabolism of human cancer cells. Then he moved to the molecular virology field, studying the role of glycolipids in HIV-1 fusion. In 2002, he published with Prof. Nouara Yahi a seminal article in JBC in which they described for the first time the common sphingolipid-binding domain (SBD) that mediates the attachment of viral, bacterial, and amyloid proteins to membrane sphingolipids. At this time, he decided to move to the neurosciences field, working on the molecular organization of the synapse and neurodegenerative diseases. In 2015, Prof. N. Yahi and he published a textbook entitled “Brain Lipids in Synaptic Function and Neurological Disease. Clues to Innovative Therapeutic Strategies for Brain Disorders”. More recently he used dedicated molecular modeling approaches to study lipid–lipid and lipid–protein interactions in reconstituted biological membrane systems. These methods were successfully used for conformational and ligand-binding studies of a broad range of human, rodent, insect, bacterial, and virus proteins in a fully controlled membrane environment.