Dr. Meredith Gregory-Ksander is an associate scientist at Schepens Eye Research Institute and an assistant professor in the Department of Ophthalmology at Harvard Medical School. Dr. Meredith Gregory-Ksander received her Ph.D. in Cell Biology, Neurobiology, and Anatomy from Loyola University of Chicago in 1999 and completed a postdoctoral fellowship at Schepens Eye Research Institute before joining the faculty at Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School in 2004. With expertise in cell biology and immunology, Dr. Meredith Gregory-Ksander has had a longstanding interest in how age-related changes in immune privilege and subsequent inflammation contribute to the development of glaucoma. Her laboratory has worked with several mouse models of glaucoma, including the pigmentary dispersion model in DBA/2J mice, the TNFα inducible model, the open-angle glaucoma model in SGC a1-deficient mice, and most recently the microbead occlusion model. Dr. Meredith Gregory-Ksander has identified two critical mediators of ocular inflammation during the development of glaucoma: the Fas ligand and the NLRP3 inflammasome. Current studies in her laboratory focus on how these molecules mediate protective immunity and immune privilege in the eye and how age-related changes in these molecules may contribute to the development of glaucoma.
